Protein dependent fate of hepatic cells under nicotine induced stress and curcumin ameliorated condition

Nuciferine, extracted from Nelumbo nucifera Gaertn, inhibits tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer

“…Several previous studies elucidated that extracts of natural plant could prevent or slow the severity of nicotine toxicity (Banerjee et al, 2012;Chattopadhyay et al, 2010). In this work, we focus on the ameliorative effect of NF on nicotine-induced tumor cell proliferation.…”

Nicotine Alters the Proteome of Two Human Pancreatic Duct Cell Lines

“…In PanC1, certain membrane proteins appear to be down-regulated upon nicotine treatment, such as those involved in cell adhesion and transmembrane/ion transport as well as oxidative phosphorylation [41]. In HPNE, up-regulated proteins included those involved in cytokine response, steroid biosynthesis, cell migration, extracellular structure organization and the JAK/STAT signaling pathway, all of which have been implicated as cellular responses to nicotine [17, 20, 42]. Cell division, ribosomes, and certain cell cycle proteins trended down in HPNE and up in PanC1, emphasizing the different effects that nicotine has on the cell lines.…”

Drugs of abuse and addiction: A slippery slope toward liver injury

“…Expression of p65, Bcl-2 and Bax were induced post nicotine treatment [108]. Serum TNF-α, and IL-6 levels were also increased after nicotine exposure [108]. Study in rats suggests that nicotine metabolism is not M A N U S C R I P T…”

“…Female albino rats administered nicotine subcutaneously demonstrates extensive DNA damage and hepatic cell death possible by up-regulation of pro-apoptotic proteins [108]. Expression of p65, Bcl-2 and Bax were induced post nicotine treatment [108]. Serum TNF-α, and IL-6 levels were also increased after nicotine exposure [108].…”

“…Level of malondialdehyde was increased, while thiol concentration was reduced after nicotine exposure [107]. Female albino rats administered nicotine subcutaneously demonstrates extensive DNA damage and hepatic cell death possible by up-regulation of pro-apoptotic proteins [108]. Expression of p65, Bcl-2 and Bax were induced post nicotine treatment [108].…”