Protein Delivery: Bioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery (Adv. Mater. 29/2018)

Abstract

In article number https://doi.org/10.1002/adma.201801198, Wen‐fei Dong, Kam W. Leong, and co‐workers report the development of an efficient protein‐delivery system comprising new biodegradable diselenide‐bridged mesoporous silica nanoparticles (MSNs) cloaked with cancer‐cell‐derived membrane fragments. The MSNs show oxidative and redox dual‐responsive matrix‐degradation behavior for controlled release of RNase A. They also exhibit prolonged blood circulation, favorable tumor accumulation, and low toxicity.

Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy

“…Cell membrane coating replicates the complex cell surface properties and critical functions of the cell type used (43,44,64). For example, platelet membranecloaked nanoparticles display selective adhesion to damaged vasculatures and enhanced binding to platelet-adhering pathogens (44), cancer cell membrane-coated nanoparticles exhibited homologous targeting and immune-invasion characteristics (65), and pancreatic beta cell membrane-coated nanofiber scaffolds improve beta cell proliferation rate and functions such as glucose-dependent insulin secretion versus the same beta cells cultured in unmodified nanofiber scaffolds (45). In the current study, we showed that the MSCM layer coating the NF was slightly thicker and rougher than that of membranes on spherical nanoparticles.…”

Nanoarchitecting Hierarchical Mesoporous Siliceous Frameworks: A New Way Forward

“…Considering these facts, precise re-engineering of siliceous frameworks that can achieve controlled degradation in the specific microenvironment alongside exhibiting the therapeutic effects is desirable (Maggini et al, 2016;Yang et al, 2016b). Indeed, one of such environments is the intracellular reductive microenvironment that with enriched glutathione (GSH) content enables the redox-triggered biodegradation of hybrid materials installed with disulfide or thioethers, such as bis (propyl)disulfide, (-(CH 2 ) 3 -S $ S-(CH 2 ) 3 -) and bis (propyl)tetrasulfide (-(CH 2 ) 3 -S $ S $ S $ S-(CH 2 ) 3 -), or diselenide-bridged moieties (Figures 4A and 4B) (Du et al, 2018b;Kankala et al, 2020a;Kim et al, 2012;Quesada et al, 2013;Shao et al, 2018;Teng et al, 2014 (Kim et al, 2012). Copyright 2012, American Chemical Society.…”

“…In this vein, several efforts have been dedicated in recent times to demonstrate the efficacy of disulfide/diselenidebridged mesoporous frameworks for cancer drug delivery and the biocompatibility of these responsive frameworks even at high doses (Huang et al, 2017;Wu et al, 2015). Comparatively, the stimuli-responsive diselenide linkage is more advantageous owing to its lower bond energy of 240 kJ/mol and relatively weaker electronegativity over disulfide bond (172 kJ/mol), indicating its susceptibility to the reductive environment (Shao et al, 2018).…”

“…Along this line, numerous reports demonstrated the compatibility attributes of MSNs in various levels ranging from cellular in vitro to animal studies in vivo by multiple modifications (Kankala et al, 2019(Kankala et al, , 2020a. In the vein of enhancing their physicochemical characteristics, multiple advancements have been made, such as surface coating of biocompatible polymers/peptides/biological membranes (Niedermayer et al, 2015;Shao et al, 2018;Zhang et al, 2015b), tethering the responsive linkers enabling their degradation (Croissant et al, 2014a;Du et al, 2018a;Maggini et al, 2016;Wang et al, 2019c), and modifying the siliceous frameworks (Kankala et al, 2015;Liu et al, 2019), as well as mesopore ordering (Niu et al, 2010;Wang et al, 2016), among others. Such innovative modifications enable tuning the sizes, surfaces, and siliceous frameworks toward fabricating the sophisticated, complex architectures by innovative chemistries (Wen et al, 2017).…”

Full‐Color Reflective Filters in a Large Area with a Wide‐Band Tunable Absorber Deposited by One‐Step Magnetron Sputtering

“…[11,12] The next category is a structured color filter based on surface plasmon resonance effects, which is a periodic subwavelength array of nanocavity structures that absorb visible light over a range of wavelengths. [13][14][15][16][17][18][19] The most commonly used design is metal-insulator-metal (MIM) film stacks, where the layer is nanopatterned by complicated lithographic procedures. Compared to the abovementioned colors based on electronic structure or the plasmonic effect, which are impractical to industrialize due to the complexity, durability and limited size, [14,20] a metal-based reflective color filter is indeed a widely applicable approach to achieve various colors by utilizing optical interference effects in planar thin-film structures.…”