Protein coronas formed by three blood proteins and food-borne carbon dots from roast mackerel: Effects on cytotoxicity and cellular metabolites

Cui, Guoxin; Zhang, Lijuan; Zaky, Ahmed A.; Liu, Ronggang; Wang, Haitao; EL-ATY, A.M.A.B.D.; Tan, Mingqian

doi:10.1016/j.ijbiomac.2022.07.196

Cited by 6 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Upon oral administration, it is expected that these carbon dots will interact with blood proteins, resulting in the spontaneous formation of PCs. In a pioneering study, Cui et al investigated the interaction between carbon dots derived from roasted mackerel and three major blood proteins: albumin, gamma globulin, and fibrinogen [69]. Their main objective was to evaluate the influence of these carbon dots on the physiological effects such as cytotoxicity and metabolic response.…”

Section: (B) Decreasing Cytotoxicitymentioning

confidence: 99%

A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications

Önal Acet,

Gül,

Stauber

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed the dynamic structure and nano–bio interactions of the protein corona. The binding of proteins not only imparts new surface identities to nanoparticles in biological fluids but also significantly influences their bioactivity, stability, and targeting specificity. Interestingly, recent endeavors have been undertaken to harness the potential of the protein corona instead of evading its presence. Exploitation of this ‘protein–nanoparticle alliance’ has significant potential to change the field of nanomedicine. Here, we present a thorough examination of the latest research on protein corona, encompassing its formation, dynamics, recent developments, and diverse bioapplications. Furthermore, we also aim to explore the interactions at the nano–bio interface, paving the way for innovative strategies to advance the application potential of the protein corona. By addressing challenges and promises in controlling protein corona formation, this review provides insights into the evolving landscape of the ‘protein–nanoparticle alliance’ and highlights emerging.

show abstract

Section: (B) Decreasing Cytotoxicitymentioning

confidence: 99%

A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications

Önal Acet,

Gül,

Stauber

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Oxidative stress can cause mitochondrial dysfunction and reduce MMP. This is an early apoptotic event and can be measured by JC-1 [22]. JC-1 aggregates exhibit red fluorescence, suggesting higher MMP, while the JC-1 monomer with green fluorescence shows lower MMP.…”

Section: Effects Of De On Mmpmentioning

confidence: 99%

Dandelion (Taraxacum mongolicum) Extract Alleviated H2O2-Induced Oxidative Damage: The Underlying Mechanism Revealed by Metabolomics and Lipidomics

Chen,

Fei,

et al. 2023

Foods

Self Cite

View full text Add to dashboard Cite

Dandelion has received wide attention in food and medicine fields due to its excellent antioxidant properties. Nonetheless, the underlying mechanism of this action has not yet been fully clarified, particularly at the metabolic level. Herein, the effects of dandelion extract (DE) on H2O2-induced oxidative damage was investigated. The results indicate that the DE alleviated H2O2-induced cell damage (increased by 14.5% compared to H2O2 group), reduced the reactive oxygen species (ROS) level (decreased by 80.1% compared to H2O2 group), maintained the mitochondrial membrane potential (MMP) level, and increased antioxidant-related enzyme activities. Importantly, the metabolic response of PC12 cells indicates that H2O2 disturbed phospholipid metabolism and damaged cell membrane integrity. In addition, energy metabolism, the central nervous system, and the antioxidant-related metabolism pathway were perturbed. In contrast, DE rescued the H2O2-induced metabolic disorder and further alleviated oxidative damage. Collectively, these findings provide valuable stepping stones for a discussion of the mechanism and show the promise of DE as a suitable additive for functional food products.

show abstract

“…46 In a study of the protein corona, researchers found that the endogenous nanoparticle protein corona formed by grilled salmon in human serum protein can considerably reduce the glycolysis metabolism of normal rat kidney cells, indicating that it can lead to the recovery of oxidative phosphorylation levels. 47 According to further studies, the protein corona formed in grilled salmon can reduce nanoparticle-induced mitochondrial damage. 48 The protein corona structure formed by roast beef in human serum proteins relieves the swelling of cells induced by lysosomes and inhibits the reduction of the mitochondrial membrane potential caused by nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

PVA/KGM dual network hydrogels doped with carbon nanotube-collagen corona as flexible sensors for human motion monitoring

Cao,

He,

Sui

et al. 2024

J. Mater. Chem. C

View full text Add to dashboard Cite

show abstract

Protein coronas formed by three blood proteins and food-borne carbon dots from roast mackerel: Effects on cytotoxicity and cellular metabolites

Cited by 6 publications

References 40 publications

A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications

A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications

Dandelion (Taraxacum mongolicum) Extract Alleviated H2O2-Induced Oxidative Damage: The Underlying Mechanism Revealed by Metabolomics and Lipidomics

PVA/KGM dual network hydrogels doped with carbon nanotube-collagen corona as flexible sensors for human motion monitoring

Contact Info

Product

Resources

About