Protein C deficiency and acute myocardial infarction in the third decade

Hacker, Steven M.; Williamson, Brian D.; Lisco, Steven J.; Kure, James; Shea, Michael J.; Pitt, Bertram

doi:10.1016/0002-9149(91)90730-9

Cited by 17 publications

(10 citation statements)

References 4 publications

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“…Their deficiencies induce hypercoagulability and usually manifest themselves with recurrent venous thromboembolism [1,2]. Arterial thrombotic events such as native coronary artery and graft occlusion have also been reported [3][4][5][6][7][8][9][10]. The incidence of clinical onset is more prevalent before 40 years of age, with a peak in the third decade [1].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are several case reports regarding protein C and/or protein S deficiencies coexisting with acute myocardial infarction [3][4][5][6][7][8][9][10] and even recurrent myocardial infarction has been reported in such patients [5,7,9]. To our knowledge, however, there are no publications on acute stent thrombosis secondary to the combined protein C and S deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Their association with arterial thrombosis is less appreciated [1,2]. Acute myocardial infarction due to protein C and/or protein S deficiencies has been reported in the literature [3][4][5][6][7][8][9][10]. To our knowledge, however, there are no publications about acute stent thrombosis following percutaneous coronary intervention in patients with protein C and S deficiencies.…”

Section: Introductionmentioning

confidence: 99%

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Recurrent acute stent thrombosis associated with protein C and S deficiencies

Acar

Doğan

Altınbaş

et al. 2006

Int J Cardiovasc Imaging

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Protein C and protein S deficiencies may uncommonly be responsible for coronary arterial thrombosis. We report a young woman with recurrent acute stent thrombosis due to the deficiency of protein C and S. After coronary stenting, stent thrombosis occurred two times despite aggressive antiplatelet therapy, including aspirin, clopidogrel and glycoprotein IIb/IIIa inhibitor. This report suggests that the deficiency of protein C and S should be born in mind in a young patient with recurrent thrombotic events, and that anticoagulants in addition to antiplatelet agents considered in the presence of their deficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recurrent acute stent thrombosis associated with protein C and S deficiencies

Acar

Doğan

Altınbaş

et al. 2006

Int J Cardiovasc Imaging

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“…In conclusion, therefore, it is important to recognise protein-C deficiency as a significant risk factor in young patients presenting with ischaemic stroke or myocardial infarction of unknown cause. 5 However, the study of protein-C deficiency causing CAD or CVA must involve a large population in multicentres. This case is presented for its rarity namely-1.…”

Section: Resultsmentioning

confidence: 99%

Ischaemic Stroke in Young Woman Due to Protein-C Deficiency

Pitchai¹,

Ramu²,

Mathiyazhakan³

et al. 2017

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“…1,3 Protein C deficiency typically causes venous thromboembolism. However few case reports of arterial thrombosis due to congenital protein C deficiency involving cardiac and cerebral vessels in young adults have been reported, [4][5][6][7][8][9][10][11][12] though larger studies give conflicting data regarding existence of association between protein C deficiency and arterial thrombosis. [13][14][15][16][17] We report a case of congenital protein C deficiency with acute myocardial infarction in a young adult without major underlying coronary risk factors.…”

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confidence: 99%