Protein and Nucleic Acid Metabolism in the Testes of Zinc-deficient Rats

Macapinlac, M. P.; Pearson, William N.; Barney, G. H.; Darby, William J.

doi:10.1093/jn/95.4.569

Cited by 61 publications

(16 citation statements)

References 28 publications

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“…The zinc deficiency observed in the present study appears, therefore, to be related to the lipid accumulation observed by Lacy (1967) and Kochar & Harrison (1971). Macapinlac, Pearson, Barney & Darby (1968) reported that an increased catabolism of protein and RNA occurs in the testes of zinc-deficient rats rather than a decrease in their synthesis. Since RNA (Gupta & Bawa, 1970, 1974b and 65Zn decline in irradiated testes, the possibility of catabolism of RNA due to zinc deficiency cannot be excluded.…”

Section: Methodssupporting

confidence: 69%

Radiation Effects on Testes

Gupta¹,

Bawa²

1975

Reproduction

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Section: Methodssupporting

confidence: 69%

Radiation Effects on Testes

Gupta¹,

Bawa²

1975

Reproduction

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“…Depasquale-Jardieu & Fraker (1979) reported that Zn deficiency caused an increase in plasma corticosterone level which in turn destroyed thymic 1ymphocytes.The splenomegaly observed (Gupta, 1984) might have also resulted in some degree of lymphocytopenia. Lymphocytopenia due to Zn deficiency has also been reported in rats (Macapinlac et al 1966). In group ZnR, the serum Zn concentration increased rapidly within 3 d of repletion.…”

Section: Smentioning

confidence: 82%

Experimental zinc deficiency in guinea-pigs: clinical signs and some haematological studies

1985

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1. Thirty-three male, weanling guinea-pigs were divided into two groups. One group was fed on a zinc-deficient (ZnD) diet (1.25 mg Zn/kg diet) for 45 d and then divided into two subgroups: subgroup 1 continued on diet ZnD while subgroup 2 was fed on a Zn-repleted diet (100 mg Zn/kg diet) for 15 d. The second group was fed on a Zn-adequate diet (50 mg Zn/kg diet) for 60 d.2. Zn deficiency could be produced within 21 d as evidenced by clinical signs and reduction in serum Zn concentration.3. Clinical signs exhibited were listlessness, scabby lesions on skin near the foot pads, mild alopecia and a reduction in body-weight gain. No effect was observed on food intake.4. Significant decreases in packed cell volume and total leucocyte count from 48 d onwards accompanied by absolute lymphocytopenia and relative neutrophilia were observed.5. Supplementation of Zn in the Zn-repleted group resulted in marked, though incomplete, improvement with regard to serum Zn concentration, clinical signs and haematological changes.

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“…However, liver ribosomal RNA was reduced 33 % following prolonged treatment of rats with cortisone with only slight changes in synthetic and degradation rates (Loeb and Tolentino 1970). Macapinlac et al (1968) showed reductions of RNA in testicular tissues without altered synthesis in the testicular tissues of zinc-deficient rats. The suggestion of these last authors that RNA was being catabolized at an increased rate in such animals was supported by Somers and Underwood (1969).…”

Section: Discussionmentioning

confidence: 98%