Protein adsorption on magnesium and its alloys: A review

Höhn, Sarah; Virtanen, Sannakaisa; Boccaccını, Aldo R.

doi:10.1016/j.apsusc.2018.08.173

Cited by 117 publications

(63 citation statements)

References 84 publications

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“…While the question of whether proteins promote or reduce the degradation rate is still subject to discussion in literature, there is consensus that proteins affect the degradation rate and determine the formation of degradation products. 48,49 Proteins can build chelate complexes which can increase the dissolution rate of Mg(OH) 2 . 47 In the same work, it was shown by Fourier-transform infrared (FTIR) spectroscopy that proteins have a significant impact on the formation of passivating calcium phosphate layers, which is inhibited in the presence of proteins.…”

Section: Cell-free Situationmentioning

confidence: 99%

The Interface Between Degradable Mg and Tissue

Willumeit‐Römer

2019

JOM

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Magnesium (Mg) and its alloys degrade under physiological conditions, which makes them interesting implant materials, especially for osteosynthesis and cardiovascular applications. However, how strong is the connection between the implant, the degradation layer, and the surrounding tissue, namely bone? Considering that microscopically the interface can be separated into the border between the metal and the degradation layer, the degradation layer itself, and the border between the degradation layer and the biological environment, it is not obvious that this zone with total thickness of several tens of microns is sufficient to keep an implant in place. However, biomechanical approaches such as push-out tests have shown that a degraded Mg pin is surprisingly well connected with the bone irrespective of the fragile appearance of the degradation layer. This paper provides an overview of what is known about the interface between degrading Mg implants, cells, and bone tissue.

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Section: Cell-free Situationmentioning

confidence: 99%

The Interface Between Degradable Mg and Tissue

Willumeit‐Römer

2019

JOM

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“…However, Mg corrodes easily both in vitro and in vivo due to a relatively low standard electrode potential [5]. Rapid corrosion leads to premature loss of mechanical integrity [6], an alkaline local environment [8,9], and a massive release of degradation by-products (Mg 2+ , hydroxyl ion, and hydrogen gas) [10][11][12][13], which further cause implant failure and induce adverse effects. Therefore, strategies to decrease the corrosion rate to better match the bone healing rate have become a research focus [14].…”

Section: Introductionmentioning

confidence: 99%

Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2–coated β-TCP/Mg-Zn orthopedic implants: An in vitro and in vivo study

et al. 2020

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Magnesium-based biomaterials are attracting increasingly more attention for orthopedic applications based on their appropriate mechanical properties, biodegradability, and favorable biocompatibility. However, the high corrosion rate of these materials remains to be addressed. In this study, porous β-Ca 3 (PO 4) 2 /Mg-Zn (β-TCP/Mg-Zn) composites were fabricated via a powder metallurgy method. The β-TCP/Mg-Zn composites with 6% porosity exhibited optimal mechanical properties, and thus, they were selected for surface modification. A novel dopamine/gelatin/recombinant human bone morphogenetic protein-2 (rhBMP-2) coating with demonstrated stability was prepared to further improve the corrosion resistance of the composite and enhance early osteoinductivity. The homogeneously coated β-TCP/Mg-Zn composite showed significantly improved corrosion resistance according to electrochemical and immersion tests. In addition, extracts from the dopamine/ gelatin/rhBMP-2-coated β-TCP/Mg-Zn composite not only facilitated cell proliferation but also significantly enhanced the osteogenic differentiation of Sprague-Dawley rat bone marrow-derived mesenchymal stem cells in vitro. Furthermore, in vivo experiments were performed to evaluate the biodegradation, histocompatibility, and osteoinductive potential of the coated composite. No obvious pathological changes in the vital visceral organs were observed after implantation, and radiography and hematoxylin-eosin staining showed strong promotion of new bone formation, matched composite degradation and bone regeneration rates, and complete absorption of the released hydrogen gas. Collectively, these results indicate that the dopamine/gelatin/rhBMP-2-coated β-TCP/Mg-Zn composite offers improved corrosion resistance, favorable biocompatibility, and enhanced osteoinductive potential for use in the fabrication of orthopedic implants.

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“…Due to the protein adsorption on the surface of biomaterials is always considered as the first step of many undesired bio‐reactions and bio‐responses . To evaluate the antifouling property, the protein adsorption on the PVA‐g‐pMEDSAH hydrogel was tested.…”

Section: Resultsmentioning

confidence: 99%

Surface modification PVA hydrogel with zwitterionic via PET‐RAFT to improve the antifouling property

Zhou

Lin

et al. 2019

J of Applied Polymer Sci

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To improve the antifouling property, polyvinyl alcohol hydrogel was successfully grafted with [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (MEDSAH) via photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization under a 10 W blue (450-460 nm) light-emitting diodes. It is surprising that the reaction could be performed in the presence of oxygen, which meant that the reaction has a great prospect of industrialization. The highest grafting percentage (GP) was 55.77% by adding triethylamine and changed the MEDSAH usage in the absence of oxygen. Thermal gravimetric analysis exhibited that grafted MEDSAH affects the thermal property of PVA hydrogel. Also, there was no influence on the ultraviolet-visible transmittance, and the PVA-g-pMEDSAH hydrogel became hydrophilicity after grafting. Moreover, in vitro cytotoxicity of both PVA and PVA-g-pMEDSAH hydrogel was noncytotoxic according to ISO 10993-2009. The antifouling property of PVA-g-pMEDSAH hydrogel was increased about 53.05%. Thus, the PVA-g-pMEDSAH hydrogel can be an ideal optical biomaterial candidate.

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Protein adsorption on magnesium and its alloys: A review

Cited by 117 publications

References 84 publications

The Interface Between Degradable Mg and Tissue

The Interface Between Degradable Mg and Tissue

Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2–coated β-TCP/Mg-Zn orthopedic implants: An in vitro and in vivo study

Surface modification PVA hydrogel with zwitterionic via PET‐RAFT to improve the antifouling property

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