Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2–coated β-TCP/Mg-Zn orthopedic implants: An in vitro and in vivo study

Liu, Congcong; Wang, Jingcheng; Gao, Chengde; Wang, Zhenting; Zhou, Xiaohua; Tang, Mingxi; Yu, Kun; Deng, Youwen

doi:10.1371/journal.pone.0228247

Cited by 15 publications

(17 citation statements)

References 74 publications

(94 reference statements)

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“…In vitro assessment confirmed that the Sr doped CaP coating ZK60 Mg alloy substrate enhanced corrosion resistance, improved bioactivity, promoted cell adhesion and proliferation and the in vivo study revealed that Mg alloy improved biocompatibility and excellent osteointegration through higher bone regeneration post-implantation in a rabbit model (Makkar et al, 2020). Moreover, another in vitro study was performed on composite (gelatin/dopamine /rhBMP-2-coated β-TCP/Mg-Zn) coated Mg substrate to enhance biocorrosion and osteoconductivity (Liu et al, 2020). In vitro study revealed that the composite coated substrate not only improved biodegradation but also cell proliferation.…”

Section: Biocompatibility Of Coatingsmentioning

confidence: 75%

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Magnesium Alloys With Tunable Interfaces as Bone Implant Materials

Rahman

Dutta

Choudhury

2020

Front. Bioeng. Biotechnol.

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Magnesium (Mg) based biodegradable materials are a new generation orthopedic implant materials that are intended to possess same mechanical properties as that of bone. Mg alloys are considered as promising substitutes to permanent implants due to their biodegradability in the physiological environment. However, rapid corrosion rate is one of the major constraints of using Mg alloys in clinical applications in spite of their excellent biocompatibility. Approaches to overcome the limitations include the selection of adequate alloying elements, proper surface treatment, surface modification with coating to control the degradation rate. This review focuses on current advances on surface engineering of Mg based biomaterials for biomedical applications. The review begins with a description of corrosion mechanism of Mg alloy, the requirement for appropriate surface functionalization/coatings, their structure-property-performance relationship, and suitability for biomedical applications. The control of physico-chemical properties such as wettability, surface morphology, surface chemistry, and surface functional groups of the coating tailored by various approaches forms the pivotal part of the review. Chemical surface treatment offers initial protection from corrosion and inorganic coating like hydroxyapatite (HA) improves the biocompatibility of the substrate. Considering the demand of ideal implant materials, multilayer hybrid coatings on Mg alloy in combination with chemical pretreatment or inorganic HA coating, and protein-based polymer coating could be a promising technique to improve corrosion resistance and promote biocompatibility of Mg-based alloys.

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Section: Biocompatibility Of Coatingsmentioning

confidence: 75%

“…Yellow arrows, periosteal reaction/callus; green arrows, hydrogen bubble; blue arrows, residual implant. (a-c) Anteroposterior view of femurs in the experimental group; (e-g) lateral view of femurs in the experimental group; (d,h) anteroposterior and lateral view of femurs in the control group(Liu et al, 2020).…”

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confidence: 99%

Magnesium Alloys With Tunable Interfaces as Bone Implant Materials

Rahman

Dutta

Choudhury

2020

Front. Bioeng. Biotechnol.

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“…Whereas 3D-polylactic acid (PLA) scaffold coated with gelatin and mucic acid supported cell adhesion, promoted osteogenic differentiation of murine embryonic fibroblast cell line (C3H10T1/2 cell line), and ECM mineralization, as shown by Ashwin et al [77]. Liu et al [74] covered porous β-Ca 3 (PO 4 ) 2 /Mg-Zn (β-TCP/Mg-Zn) composites with dopamine/gelatin/recombinant human BMP-2 coating. The applied coating improved cell proliferation and enhanced bALP activity in BMDSCs in vitro and improved bone regeneration in vivo.…”

Section: Inorganic and Composite Coatingsmentioning

confidence: 97%

“…Table 1 shows a summary of the research concerning surface modifications of biomaterials using inorganic and composite coatings to improve osteoconductive and osteoinductive properties of the biomaterials for bone regeneration. [70,71], whey protein isolate [72], collagen [73], and BMP-2 [74]-are organic materials which may be used in the coating process of metallic and ceramic biomaterials for bone tissue engineering applications. Organic coatings are not only characterized by high cytocompatibility and biodegradability, but they may also prevent metallic implants and ceramic materials against corrosion and uncontrolled degradability, respectively [75].…”

Section: Inorganic and Composite Coatingsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

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“…Yu et al (2012) deposited a β-TCP coating on a Mg-6Zn alloy in order to evaluate its in vivo degradation behaviour and the results indicated that the coated alloy exhibited favourable biocompatibility and was capable of improving the concrescences of the prebroken bone tissue. Liu et al (2020) deposited a newly obtained dopamine/gelatine/recombinant human bone morphogenetic protein-2 (rhBMP-2) coating on a porous β-TCP/Mg-Zn composite in order to investigate the biomaterial's in vivo behaviour. The results showed an improved corrosion resistance coupled with a favourable biocompatibility and improved new bone formation.…”

Section: Surface Coatingsmentioning

confidence: 99%

In vitro and in vivo biological performance of Mg-based bone implants

Negrescu¹,

Necula²,

Costache³

et al. 2020

Rev. Biol. Biomed. Sci.

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With the rapid advancement of medical technology, it is crucial that a considerable body of biomaterials are taken into consideration and tested for the purpose of bone implant fabrication. Over the last decades degradable metallic materials have attracted increasing interest in the field of hard tissue engineering due to their ability to degrade once they have fulfilled their function, without causing side effects that could potentially be harmful for the human body. In this context, Mg-based biomaterials gained special attention due to their bone-like mechanical properties, good biocompatibility and osteoconductive properties. However, their use in biomedical applications is limited due to their rapid corrosion in physiological environments. Therefore, it is important to reduce the degradation process of these biomaterials for safe biomedical applications. Two main strategies that could potentially lead to a lower corrosion rate are represented by alloying and surface treatment. This review provides a summary of the recent specialized literature concerning Mg-based biomaterials with a special focus on the recent in vitro and in vivo studies regarding Mg-based bone implants.

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Enhanced osteoinductivity and corrosion resistance of dopamine/gelatin/rhBMP-2–coated β-TCP/Mg-Zn orthopedic implants: An in vitro and in vivo study

Cited by 15 publications

References 74 publications

Magnesium Alloys With Tunable Interfaces as Bone Implant Materials

Magnesium Alloys With Tunable Interfaces as Bone Implant Materials

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

In vitro and in vivo biological performance of Mg-based bone implants

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