Protein adhesion and cell response on atmospheric pressure dielectric barrier discharge-modified polymer surfaces

D’Sa, Raechelle A.; Burke, George; Meenan, Brian J.

doi:10.1016/j.actbio.2010.01.015

Cited by 62 publications

(41 citation statements)

References 40 publications

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“…The reactive oxygen groups slowly decompose to form more stable oxidative groups such as hydroxyls. A detailed explanation of the oxidation of PMMA observed by XPS analysis after DBD modification has been previously reported by us [44]. In the case of DLC-coated samples, they had less oxygen and hydrocarbon groups.…”

Section: Resultssupporting

confidence: 54%

Nanoscale surface modifications to control capillary flow characteristics in PMMA microfluidic devices

et al. 2011

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Polymethylmethacrylate (PMMA) microfluidic devices have been fabricated using a hot embossing technique to incorporate micro-pillar features on the bottom wall of the device which when combined with either a plasma treatment or the coating of a diamond-like carbon (DLC) film presents a range of surface modification profiles. Experimental results presented in detail the surface modifications in the form of distinct changes in the static water contact angle across a range from 44.3 to 81.2 when compared to pristine PMMA surfaces. Additionally, capillary flow of water (dyed to aid visualization) through the microfluidic devices was recorded and analyzed to provide comparison data between filling time of a microfluidic chamber and surface modification characteristics, including the effects of surface energy and surface roughness on the microfluidic flow. We have experimentally demonstrated that fluid flow and thus filling time for the microfluidic device was significantly faster for the device with surface modifications that resulted in a lower static contact angle, and also that the incorporation of micro-pillars into a fluidic device increases the filling time when compared to comparative devices.

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Section: Resultssupporting

confidence: 54%

Nanoscale surface modifications to control capillary flow characteristics in PMMA microfluidic devices

et al. 2011

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“…Since cells require the presence of specific regions of the proteins to adhere to the surface this change in conformation can lead to the reduction in cell attachment. Whereas on more hydrophilic surfaces it is more likely that the proteins will maintain their natural 3D conformation when they adsorb onto the surface and thus maintain the necessary binding sites for cell attachment . It was hypothesized that the oxygen incorporation into treated surfaces resulting in an increase in hydrophilicity and would encourage serum protein adsorption with a conformation promoting cellular attachment, although it is well recognized that there is not a specific contact angle at which the optimal protein interactions occur.…”

Section: Resultsmentioning

confidence: 99%

Polystyrene Surface Modification for Localized Cell Culture Using a Capillary Dielectric Barrier Discharge Atmospheric‐Pressure Microplasma Jet

Doherty

Unsworth

et al. 2013

Plasma Processes & Polymers

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This paper reports the spatially resolved surface modification of polystyrene (PS) using an atmospheric‐pressure microplasma jet. Treatment of PS surfaces using a microplasma jet with a 100 µm diameter is investigated using contact angle, XPS, AFM and lens epithelial cell (LEC) growth. Microplasma jet treatment creates a defined reduction in contact angle of approximately 60° in a circular pattern with a diameter of 1.5 mm or more. Spatially resolved XPS analysis demonstrates that a reduction in contact angle is related to an increase in O1s peak intensity. AFM confirms that microplasma jet treatment causes no significant change in surface roughness. LECs are confined to a treated area.

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“…It is widely known that material properties such as the surface chemistry, wettability and roughness can affect the cellular response [74][75][76][77]. This could be achieved by modifying a surface to enable attachment of a LEC monolayer that maintains an epithelial phenotype.…”

Section: Cornea and Conjunctivamentioning

confidence: 99%

Biomaterials for ocular reconstruction

2014

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Synthetic materials have played a significant role in ophthalmic applications to improve vision for many years. This has been in four main areas in ophthalmology: ocular surface reconstruction, lens replacement, vitreous replacement and structural support and cell transplantation in the retina. Corneal replacement therapies have been developed using both synthetic acrylic-based materials and more recently naturally derived materials such as amniotic membrane.

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Protein adhesion and cell response on atmospheric pressure dielectric barrier discharge-modified polymer surfaces

Cited by 62 publications

References 40 publications

Nanoscale surface modifications to control capillary flow characteristics in PMMA microfluidic devices

Nanoscale surface modifications to control capillary flow characteristics in PMMA microfluidic devices

Polystyrene Surface Modification for Localized Cell Culture Using a Capillary Dielectric Barrier Discharge Atmospheric‐Pressure Microplasma Jet

Biomaterials for ocular reconstruction

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