Protective role of resveratrol against cisplatin induced ototoxicity in guinea pigs

Yumuşakhuylu, Ali Cemal; Yazıcı, Mine; Sarı, Murat; Binnetoğlu, Adem; Kösemihal, Ebru; Akdaş, Ferda; Şirvancı, Serap; Yüksel, Meral; Üneri, Cüneyd; Tutkun, Alper

doi:10.1016/j.ijporl.2011.12.021

Cited by 51 publications

(47 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In those studies, the protective effects of resveratrol were thought to be due to its potent antioxidant properties. Yumusakhuylu et al [14] reported decreased ROS level in the resveratrol-treated Group. In addition, Kavas et al [30] studied the effects of resveratrol on the oxidant/ antioxidant systems of rats and observed statistically significant increases in superoxide dismutase and catalase activity, and in plasma copper and red blood cell zinc concentrations, as well as statistically significant decreases in the concentrations of the lipid peroxidation product MDA, and plasma zinc and copper in red blood cells in the resveratrol-administered Group.…”

Section: Discussionmentioning

confidence: 96%

“…They showed that resveratrol significantly reduced the formation of reactive oxygen species (ROS) and inhibited cyclooxygenase-2 expression following noise exposure [18] . Resveratrol was also demonstrated to have a protective effect against cisplatin ototoxicity [14][15][16] . In those studies, the protective effects of resveratrol were thought to be due to its potent antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol has anti-inflammatory, antioxidant, anticarcinogenic, and anti-ageing properties [12,13] . Although the protective effects of resveratrol against cisplatin-induced ototoxicity and noise-induced hearing loss were reported in recent studies [14][15][16][17][18] , there have been no published studies on the possible role of resveratrol in the prevention of TS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does Resveratrol Have a Protective Effect on Tympanosclerosis Formation in Experimentally Induced Otitis Media?

Kurnaz¹,

Aksoy²,

Güvenç³

et al. 2014

Int Adv Otol

View full text Add to dashboard Cite

OBJECTIVE:To evaluate the effects of resveratrol on tympanosclerosis in an experimental rat model by otomicroscopic, histopathological, and immunohistochemical examinations, and measurement of malondialdehyde levels. MATERIALS and METHODS:Twenty albino Wistar rats were used in the study. Four were randomly selected as negative controls, with no treatment or intervention. The ears of 16 rats were inoculated with Streptococcus pneumonia Type 3. They were divided into two Groups: resveratrol, at 20 mg/ kg/day dissolved in 10% ethanol, was administered orally to the resveratrol Group for 6 weeks; 10% ethanol was administered to the control Group in the same manner. Blood samples were taken for malondialdehyde measurements after the first and sixth weeks. After otomicroscopic examinations, rats were sacrificed at the end of 6 weeks for histopathological and immunohistochemical (matrix metalloproteinases 2 and 9) examinations. Livers of rats were removed for malondialdehyde measurements. RESULTS:Otomicroscopic and histopathological evaluations revealed no significant difference between the Groups. Plasma malondialdehyde level of the resveratrol Group in the first week was lower than that of the control Group (p<0.05). There was no difference in plasma and liver tissue malondialdehyde levels after 6 weeks. There was a significant difference in staining for matrix metalloproteinase 9 of tympanic membranes between the resveratrol and control Groups (p<0.05). CONCLUSION:Resveratrol has potential antioxidant activity and significantly decreases malondialdehyde levels in the first week. It has an inhibitory effect on matrix metalloproteinase 9. However, it appears to be ineffective in the prevention of tympanosclerosis when used alone, according to otomicroscopic and histopathological evaluations.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does Resveratrol Have a Protective Effect on Tympanosclerosis Formation in Experimentally Induced Otitis Media?

Kurnaz¹,

Aksoy²,

Güvenç³

et al. 2014

Int Adv Otol

View full text Add to dashboard Cite

show abstract

“…These events can cause apoptosis and consequently to a decrease the cochlear cells of the inner ear [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…The suggested mechanism of ototoxicity is the production of reactive oxygen species (ROS) that main cause of cell injury or death [2,3]. Cisplatin administration also decreases antioxidant enzymes in the cochlea [4]. When the balance between the production of ROS and antioxidative defense is damaged oxidative stress can occur which can lead to cochlear cell injury or death.…”

Section: Introductionmentioning

confidence: 99%

The Protective Role of Molsidomine on the Cisplatin-Induced Ototoxicity

Toplu

Parlakpınar

Sapmaz

et al. 2014

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

This experimental study was designed to investigate the protective effects of molsidomine (MOL) on against cisplatin-induced ototoxicity (CIO). To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status [including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPX), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI)] were evaluated. Thirty-two female wistar albino rats were divided into four groups including; control (Group K), cisplatin (Group C), cisplatin plus MOL group (Group CM), and MOL group (Group M). DPOAEs measurements between 0.9961 and 8.0003 Hz as DP-gram and input/output (I/O) functions were performed in the same (left) ear of all rats on days 0, 1st, 5th and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. In the C group, statistically significant DPOAE amplitude reductions were detected at 2. 5195, 3.1758, 3.9961, 5.0391, 6.3516 and 8.0039 Hz frequencies (p \ 0.05) between 0th and 1st, 0th and 5th and 0th and 12th days' measurements (p \ 0.05). Serum level of MDA, TAC and OSI levels were significantly higher in the C group versus K group (p \ 0.05). In the CM group, there were no significant differences at all frequencies between 0th and other days' measurements (p [ 0.05) and the serum levels of all biochemical parameters were shifted toward normal values, similar to the K group (p \ 0.05). No significant differences were detected in the either M or K group's measurements. According to these results, cisplatin-related ototoxicity has been significantly prevented by MOL.

show abstract