The Protective Role of Molsidomine on the Cisplatin-Induced Ototoxicity

Toplu, Yüksel; Parlakpınar, Hakan; Sapmaz, Emrah; Karataş, Erkan; Polat, Alaaddin; Kızılay, Ahmet

doi:10.1007/s12070-014-0718-2

Cited by 9 publications

(3 citation statements)

References 28 publications

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“…Diabetes produces a significant oxidative damage in sciatic nerve as indicated by an increase in lipid peroxidation and nitric oxide concentration as well as depletion of antioxidant enzymes. 27 Previous experimentations have shown that the oxidative stress induced by diabetes causes damage to protein, lipid, DNA and also causes damages myelin sheath surrounding the nerve. In the present study, increase in MDA levels and depletion in reduced glutathione was seen in sciatic nerve homogenate.…”

Section: Discussionmentioning

confidence: 99%

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Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Nayak

Minaz

Pasha

2021

Anim Models and Exp Med

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Diabetes mellitus (DM) prevalence is increasing at an alarming rate as it was 381 million people globally in 2013 and is estimated to be 463 million people in 2019 rising to 578 million by 2030. It is a disease with high rate of complications such as neuropathy, nephropathy, retinopathy, erectile dysfunction etc. 1,2 Diabetic neuropathy is a family of disorders that damage the different regions of the nervous system, either individually or in combination. It affects pain fibres, motor neurons and autonomic nervous system. 3 It results in large economic costs for its care. [4][5][6] The various kind of neuropathies include peripheral neuropathy, proximal neuropathy, autonomic neuropathy and focal neuropathy. 7 There are a number of reasons for the pathogenesis of diabetic neuropathy and polyol pathway of glucose metabolism is thought as one of the major mechanism. 8 Peripheral neuropathy is a type of nerve damage that usually affects feet and legs and sometimes hands and arms. 9 It is proved that reactive oxygen species (ROS) plays a significant role in the pathophysiology of neuropathic pain in diabetes. 10 Out of all diabetic patients, 50% of patients develop neuropathy and painful neuropathy ranges from 10% to 20% in patients with diabetes. Diabetic patients can experience nerve problems at any time and the problem increases with age, weight and duration. 5 The complications across various countries varies from 10% to 30% and it is higher in developed countries than in developing countries. These complications can lead to painful symptoms and can affect quality of life of the patient. The treatment for the painful diabetic

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Section: Discussionmentioning

confidence: 99%

“…Diabetes causes a significant oxidative damage in the sciatic nerve as indicated by an increase in lipid peroxidation and nitric oxide concentration, as well as depletion of antioxidant enzymes. 27 …”

Section: Discussionmentioning

confidence: 99%

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Nayak

Minaz

Pasha

2021

Anim Models and Exp Med

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“…The clinical applications of MLS in the field of cardiology are well established, especially relating to the symptomatic treatment of angina [6][7][8][9]. Apart from these properties, it is also well established that MLS exerts antioxidant and anti-inflammatory effects [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Oğuz¹,

Beytur²,

Sarihan³

et al. 2016

CIM

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Purpose: The purpose of this study was to investigate the therapeutic and protective effects of molsidomine (MLS) against doxorubicin (DOX)-induced renal damage in rats.Methods: Forty rats were randomly divided into five groups (control, MLS, DOX, DOX+MLS and MLS+DOX groups). Thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GPx) levels were determined from kidney tissues and blood urea nitrogen (BUN), creatinine (Cr) and albumin (Alb) levels also determined.Results: DOX treatment caused a significant increase in TBARS levels and a significant decrease in the GSH and CAT levels compared with the control group. In comparison, MLS administration before DOX injection caused a significant decrease in TBARS levels and also increases in GSH and CAT levels, whereas treatment of MLS after DOX injection did not show any beneficial effect on these parameters. All groups showed a significant increase in NO levels compared to the control group. There were no significant differences among the all groups for BUN and Cr levels. Serum level of Alb decreased in the DOX-treated groups when compared with control and MLS groups. The histopathological findings were in accordance with the biochemical results. MLS treatment reversed the DOX-induced kidney damage in group 4. MLS treatment before DOX injection exerted a protective effect against DOX-induced kidney damage.Conclusions: MLS shows promise as a possible therapeutic intervention for the prevention of kidney injury associated with DOX treatment. Additional studies are warranted.

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Protective role of misoprostol against cisplatin-induced ototoxicity

Doğan

Polat

Yaşar

et al. 2016

Eur Arch Otorhinolaryngol

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Cis-diammineedichloroplatinum (cisplatin) is a chemotherapeutic agent that is widely used in the treatment of many cancers. Nephrotoxicity, ototoxicity and neurotoxicity are dose-limiting adverse effects for cisplatin. The cellular and molecular mechanisms underlying cisplatin-induced ototoxicity aren't fully understood. It has been proposed that cisplatin primarily cause damage at the cochlea, outer hair cells in particular, leading to excessive production of free oxygen radicals in the organ of Corti, stria vascularis, spiral ligament, and spiral ganglionic cells. The cytotoxicity is associated with the generation of reactive oxygen species (ROS); thus, there is an increasing interest on antioxidants with an effort to discover the established protection against cisplatin-induced ototoxicity over time. Misoprostol (MP) has gained considerable interest as a reactive oxygen species scavenger in recent years. To best of our knowledge, there is no study about protective effect of MP, a prostaglandin E1 (PGE1) analogue, on cisplatin-induced ototoxicity. In our study, we show that protective effects of misoprostol on cisplatin-induced ototoxcity on rats.

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The Protective Role of Molsidomine on the Cisplatin-Induced Ototoxicity

Cited by 9 publications

References 28 publications

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Protective role of misoprostol against cisplatin-induced ototoxicity

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