Protective role of propolis against histological alterations in renal tissue induced by gold nanoparticles

Abstract

ABSTRACT:Male albino Wistar rats were exposed to 10 nm gold nanoparticles at a dose of 2000 µg/kg together with or without propolis (50 mg/kg) for 15 consecutive days. Fresh renal biopsies from of all investigated rats were cut rapidly, fixed in neutral buffered formalin, subjected to histological processing, and examined for microanatomical alterations. Propolis gave full protection against glomerular congestion and renal tubule hyaline casts. It demonstrated partial amelioration against glomerular capillary dilatation, tubular cloudy swelling, necrosis, and degeneration together with interstitial blood capillaries dilatation and haemorrhage induced by nanoparticle toxicity. On the other hand, propolis showed no protective effect against renal cells pyknosis, karyolysis, apoptosis and renal hydropic degeneration together with collecting tubules atrophy and degeneration induced by the nanoparticles. Thus propolis can augment the antioxidant defence against the severity of some alterations in the renal tissues. This ameliorative role might be related to the antioxidants content of propolis that protect the renal tissues from free radicals and oxidative stress.

Structure and Ultrastructure Study on the Potential Impacts of Gold Nanoparticles on the Periodontal Ligament of Albino Rats.

“…This could be not mention as excessive collagenase production by neutrophils. Dilatation of the blood vessels was observed in our results, this was in agreement with Almansour and Jarrar (24) who reported that microscopic examination of lung tissue of rats exposed to 10 nm GNPs showed congestion with dilated inter-alveolar septal capillaries and leakage of blood cells were seen. The looks of extra-vasated erythrocytes within the alveolar sacs may indicate compression because of edema and/or thickening of the alveolar walls.…”

“…In agreement with our results, Almansour and Jarrar. (24) reported that diffuse and evenly diffused interstitial and peribronchial mononuclear inflam-matory cell infiltration mainly lymphocytes was seen within the lungs of all members exposed to 10nm GNPs. Plasma cells and eosinophils were also seen.…”

The Biological Effect of Different Doses of Gold Nanoparticles on the Liver of Female Rats: A Histological and Immunohistochemical Study

“…Moreover, it may be considered as a compensatory response in order to clear cellular debris. These cells can also stimulate the immune cells to get rid of any foreign substances and also to help in the regeneration [51] .…”