Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: A morphological and biochemical study

The Protective Role of Chinese Prescription Kangen-karyu Extract on Diet-Induced Hypercholesterolemia in Rats

“…They were markedly elevated in hyperlipidemic animals compared to normal rats, which is consistent with other studies, 19,34,35) whereas administration of Kangen-karyu extract markedly prevented elevations in serum AST and ALT. We also measured total cholesterol in liver and feces to investigate whether the cholesterol lowering effect of Kangen-karyu extract was due to the reduction of cholesterol synthesis or the enhancement of its excretion.…”

A Brief Overview of the Effects of Melissa officinalis L. Extract on the Function of Various Body Organs

“…In addition, M. officinalis has the potential to inhibit hypercholesterolemia, to reduce serum lipid concentrations and lipid peroxidation in the liver of hypercholesterolemic rats [20]. Evidence show that herbal oils, including M. officinalis oils have various pharmacological effects which are mainly related to volatile terpenoids such as geranial, cineol and caffeic acid [5].…”

“…In another study, Bolkent et al examined the effect of M. officinalis extract on hyperlipidemic rats' liver in which liver cholesterol, total lipid, lipid peroxidation, and liver enzymes reduced while the glutathione levels increased [20].…”

The Effect of Tea-Cinnamon and <i>Melissa officinalis</i> L. Aqueous Extraction, on Neuropsychology Distress, Biochemical and Oxidative Stress Biomarkers in Glass Production Workers

“…On the other hand, many in vitro and ex vivo studies have showed antioxidant activity of Melissa officinalis extracts; but the number of in vivo studies, especially in human, is rare. The few in vivo studies have just showed that Melissa officinalis L. extract could decrease LPO in rodents [54] and in liver tissue of hyperlipidemic rats [55] and radiology staff [28] [56]. The effects of Melissa officinalis L. extract on hyperlipidemic rats has previously been studied.…”

“…The main phenolic compounds that were identified in tea infusion from Lemon balm, respectively were rosmarinic acid, luteolin 7-o-glucoside, quercetin 3-rutinoside, gallic acid, quercetin 3-o-galactoside and ferulic acid. Recent studies indicated that the oral administration of Lemon balm is beneficial in protection against oxidative stress and DNA damage in subjects exposed to long-term low-dose ionizing radiation and fatty liver diseases that a significant decrease (P = 0.0001) in LPO level and liver enzyme were observed [26]- [28] [56]. To protect glass production workers against silicon induced oxidative stress and to enhance their antioxidant defense system, the oral administration of Lemon balm and cinnamon infusion can be helpful.…”