Protective role of marine macroalgae extracts against STZ induced diabetic rats

Rayapu, Lavanya; Makkar, Fasina; Anandan, Suresh Karanam; Maneesh, Anusree; Chakraborty, Kajal; Valluru, Lokanatha

doi:10.12980/jclm.5.2017j7-153

Cited by 5 publications

(7 citation statements)

References 48 publications

(42 reference statements)

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“…In the same manner, the red alga Gelidium amansii controlled diabetes of STZ-induced diabetic rats via reducing their plasma glucose level, lipids, adipocytokines, and adipose tissue weight [124]. The efficacy of sulfated galactopyran compound from Gracilaria opuntia against diabetes and the histological changes related to it was reported by Rayapu et al [125]. Also, the aqueous extracts of Gracilaria edulis possessed an inhibitory activity of the enzymes related to diabetes [98].…”

Section: In Vivo Antihyperglycemic Activity Of Algaementioning

confidence: 69%

“…The treatment with ethyl acetate extracts of Sargassum wightii and Ulva lactuca (U. fasciata) was found to exhibit great improvement in the hepatic morphological and physiological disorders caused by diabetes [111]. The necrosis of hepatic cells, changes in microcellular fats, and wide-ranging vacuolization with the vanishing of nuclei were detected in the diabetic rat liver as observed by Rayapu et al [125]. These effects were recovered after treatment with different marine algal extracts, viz.…”

Section: Effect Of Algal Treatment On the Albumin Level Of Diabetic-i...mentioning

confidence: 74%

“…Thus, it was discovered that these seaweeds may aid to improve iron status through simple absorption by the body. Furthermore, treatment with Turbinaria conoides ethanolic extract and Sargassum wightii and T. conoides methanolic extract resulted in a rise in Hb level, which was related with a descent in blood glucose level [125]. Furthermore, treatment with Padina boergesenii aqueous extract increased Hb levels in diabetic rats significantly [117].…”

Section: Effect Of Algal Treatment On the Hemoglobin (Hb) Levels Of D...mentioning

confidence: 99%

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Antioxidant and Antidiabetic Activity of Algae

Abo-Shady¹,

Gheda²,

Ismail³

et al. 2022

Preprint

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological, cosmetic, and nutraceutical applications. Many of these bioactive compounds are secondary metabolites whose amounts in the algae vary with varying environmental conditions. Free radicals and other active oxygen derivatives are recognized as a natural by-product of aerobic metabolism. However, reactive oxygen species directly participate in mechanisms related to various pathological states such as cancer, diabetes, atherosclerosis, Alzheimer's, and Parkinson's, among others. Diabetes mellitus (DM) is a metabolic disease resulting from changes in glucose metabolism and/or deficient production/action of insulin. This review has as its main objective to reveal the potential antioxidant and antidiabetic capacity of algae extracts.

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Section: In Vivo Antihyperglycemic Activity Of Algaementioning

confidence: 69%

Section: Effect Of Algal Treatment On the Albumin Level Of Diabetic-i...mentioning

confidence: 74%

Section: Effect Of Algal Treatment On the Hemoglobin (Hb) Levels Of D...mentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady¹,

Gheda²,

Ismail³

et al. 2022

Preprint

View full text Add to dashboard Cite

Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological, cosmetic, and nutraceutical applications. Many of these bioactive compounds are secondary metabolites whose amounts in the algae vary with varying environmental conditions. Free radicals and other active oxygen derivatives are recognized as a natural by-product of aerobic metabolism. However, reactive oxygen species directly participate in mechanisms related to various pathological states such as cancer, diabetes, atherosclerosis, Alzheimer's, and Parkinson's, among others. Diabetes mellitus (DM) is a metabolic disease resulting from changes in glucose metabolism and/or deficient production/action of insulin. This review has as its main objective to reveal the potential antioxidant and antidiabetic capacity of algae extracts.

show abstract

“…In the same manner, the red alga Gelidium amansii as a diet powder could control diabetes of STZ-induced diabetic rats via reducing their plasma glucose level, lipids, adipocytokines, and adipose tissue weight [ 122 ]. The efficacy of sulfated galactopyran compound from Gracilaria opuntia against diabetes and the histological changes related to it was reported by Rayapu et al [ 123 ]. Also, the aqueous extracts of Gracilaria edulis possessed an inhibitory activity on the carbohydrate hydrolyzing enzymes [ 25 ].…”

Section: Treatment Of Diabetesmentioning

confidence: 90%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady

Gheda

Ismail

et al. 2023

Life

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological and nutraceutical applications. Due to lifestyle modifications brought on by rapid urbanization, diabetes mellitus, a metabolic illness, is the third largest cause of death globally. The hunt for an efficient natural-based antidiabetic therapy is crucial to battling diabetes and the associated consequences due to the unfavorable side effects of currently available antidiabetic medications. Finding the possible advantages of algae for the control of diabetes is crucial for the creation of natural drugs. Many of algae’s metabolic processes produce bioactive secondary metabolites, which give algae their diverse chemical and biological features. Numerous studies have demonstrated the antioxidant and antidiabetic benefits of algae, mostly by blocking carbohydrate hydrolyzing enzyme activity, such as α-amylase and α-glucosidase. Additionally, bioactive components from algae can lessen diabetic symptoms in vivo. Therefore, the current review concentrates on the role of various secondary bioactive substances found naturally in algae and their potential as antioxidants and antidiabetic materials, as well as the urgent need to apply these substances in the pharmaceutical industry.

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“…It showed 125 and 175 mg/kg concentrations of G. opuntia to treat the STZ-induced diabetic rats and also reduced the blood glucose, and HbA1c levels of G. opuntia showed a significant increase in the levels of insulin due to increased secretion of insulin from pancreatic β-cells. 33…”

Section: In Vivo Studymentioning

confidence: 99%

Antidiabetic Activity of Red Marine Algae In Vitro: A Review

Sabarianandh¹,

Subha²,

Manimekalai³

2020

Annals of SBV

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The marine ecosystem is a prosperous source of biological and chemical diversity which has been explored in the finding of unique chemicals having potential for industrial improvement as pharmaceuticals, cosmetics, nutritional supplements. Marine organisms consist of important number of novel secondary metabolites with potent pharmacological properties have been discovered. Most of the macroalgae have rich source of carotenoids, proteins, oligosaccharides, fatty acids, antioxidants, vitamins, and minerals, which are useful for medical and pharmaceutical industries. Especially, red algae are involved in photosynthesis and it also contains carrageenan, which is used for food and medicinal products. Hence, this review article is a concise of the antidiabetic effect of red algae and its bioactive components assessed in vivo and in vitro studies.

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Protective role of marine macroalgae extracts against STZ induced diabetic rats

Cited by 5 publications

References 48 publications

Antioxidant and Antidiabetic Activity of Algae

Antioxidant and Antidiabetic Activity of Algae

Antioxidant and Antidiabetic Activity of Algae

Antidiabetic Activity of Red Marine Algae In Vitro: A Review

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