Protective Role of Ethanolic Extract of Vernonia amygdalina Against Potassium Bromate Induced Tissue Damage in Wistar Rats

Josiah, SJ; Nwangwu, S. C. O.; Akintola, A.A.; Usunobun, Usunomena; Oyefule, F.S.; Ajeigbe, K.O.; Akinola, Adeniran Oluwadamilare

doi:10.3923/pjn.2012.54.57

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…This implies that more sodium ion enters in to the colonic lumen making the colonic cells more viable. This result agrees with previous reports by Josiah et al, (2012) and Atangwho et al, (2007).…”

Section: Resultssupporting

confidence: 94%

ATPases in the colon of rats fed a Nigerian like diet supplemented with folate and bitter leaf (Vernonia amygdalina)

inegbedion¹,

Eriyamremu²

2016

Int.J.Curr.Res.Aca.Rev.

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This study examined the effect of a wholly compounded Nigerian-like diet supplemented with folic acid and bitter leaf (Vernonia amygdalina) on the activity of ATPases in early colon carcinogenesis. It was also aimed to determine if any of the observed effect(s) of folic acid and bitter leaf is/are potentiated before the onset of colon carcinogenesis or also occur during the process. One hundred and twenty eight Wistar albino rats of 120g ± 0.3g were used for this study and were divided into two groups. Animals in the first group were fed with the wholly compounded food supplemented with folic acid and bitter leaf before being exposed to Cycads for two weeks (the pretreated rats) while animals in the second group were fed with Cycads for two weeks before they were exposed to the wholly compounded food supplemented with folic acid and bitter leaf (the post-treated rats). The animals in each group were subdivided into two diet classes. Animals in one group were fed with wholly compounded normal diet (ND) which served as the control class while animals in the second group were fed with wholly compounded Nigerian-like diet (NLD) which was low in protein and fat but high in carbohydrate and fiber, The animals in each diet class were further distributed into four subgroups. In each subclass, one group received the diet alone, another group received the diet and folic acid, and another group received the diet and bitter leaf, while the fourth group received the diet, folic acid and bitter leaf. The animals were given food and water ad libitum and were force fed with folic acid, bitter leaf and cycads. Such that they consumed 0.5mg/kg body weight of folic acid, bitter leaf and Cycads. Exposing the colon of rats to bitter leaf and folic acid significantly (P<0.05) increased the activity of Na +-K + ATPase but significantly (P<0.05) decreased magnesium ATPase activity and calcium ATPase activity. These results suggest that folic acid and bitter leaf (Vernonia amygdalina) may protect against colon cancer before and after its onset.

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Section: Resultssupporting

confidence: 94%

ATPases in the colon of rats fed a Nigerian like diet supplemented with folate and bitter leaf (Vernonia amygdalina)

inegbedion¹,

Eriyamremu²

2016

Int.J.Curr.Res.Aca.Rev.

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“…In addition, the weight of several organs (brain, kidney, stomach, spleen, heart, and liver) of which data were taken as indicators of inflammation and necrosis to be quantified. The results indicated that there was no relevant difference in the proportion of the weight of the organs analyzed in any dose; while the level of MDA was significantly reduced in a dose-dependent manner [23].…”

Section: Phenolic Acids and Flavonoidsmentioning

confidence: 81%

Organic Acids from Roselle (Hibiscus sabdariffa L.)—A Brief Review of Its Pharmacological Effects

et al. 2020

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Roselle (Hibiscus sabdariffa L.), also known as jamaica in Spanish, is a perennial plant that grows in tropical and subtropical regions, including China, Egypt, Indonesia, Mexico, Nigeria, Thailand, and Saudi Arabia. It has a long history of uses, mainly focused on culinary, botanical, floral, cosmetic, and medicinal uses. The latter being of great impact due to the diuretic, choleretic, analgesic, antitussive, antihypertensive, antimicrobial, immunomodulatory, hepatoprotective, antioxidant, and anti-cancer effects. These therapeutic properties have been attributed to the bioactive compounds of the plant, mainly phenolic acids, flavonoids, anthocyanins, and organic acids (citric, hydroxycitric, hibiscus, tartaric, malic, and ascorbic). Most literature reviews and meta-analyses on the therapeutic potential of Hibiscus sabdariffa L. (Hs) compounds have not adequately addressed the contributions of its organic acids present in the Hs extracts. This review compiles information from published research (in vitro, in vivo, and clinical studies) on demonstrated pharmacological properties of organic acids found in Hs. The intent is to encourage and aid researchers to expand their studies on the pharmacologic and therapeutic effects of Hs to include assessments of the organic acid components.

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“…Results indicated that anthocyanins in extract protected blood from oxidation, induced by 2,4-dinitrophenylhydrazine, and hemolysis as well as from the cytotoxic and lipid peroxidation. Josiah et al (2010) investigated the protective effect of the aqueous extract of H. sabdariffa in some damaged tissues (brain, kidney, stomach, spleen, heart, and liver), induced by potassium bromate, of rats (Rattus norvegicus). The doses of extracts used were 250 and 500 mg/kg body weight administered orally for 14 days.…”

Section: Hemo-protective Propertiesmentioning

confidence: 99%

Roselle calyces (Hibiscus sabdariffa), an alternative to the food and beverages industries: a review

Cid-Ortega

Guerrero-Beltrán

2015

J Food Sci Technol

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The need to add value to cultivated and native plant products that have medicinal and nutritional properties is increasing due to the consumers demand. Nowadays, the bioactive compounds (phytochemicals) found in plants have many uses in the therapeutic, pharmaceutical, and food industries. Dried Roselle calyces (Hibiscus sabdariffa L.) are commercially available and appreciated to obtain concentrated extracts which might be used in the food and pharmaceutical industries. It has been shown that ingestion of infusions of Roselle may help to reduce chronic diseases such as diabetes mellitus, dyslipidemia, and hypertension. This could be due to the activity of some compounds, mainly flavonoids and anthocyanins, found as natural antioxidants in Roselle extracts. Numerous researchers have pointed out that Roselle and its extracts possess functional properties from where advances can be taken for developing new products with additional nutritious characteristics that may provide health benefits to consumers. Food products from Roselle are known as functional foods, which may provide health benefits to consumers because of its significant contribution of phytochemicals. In this sense, one of the main challenges that companies face todays is the development of new value-added products to meet the consumer's demands. This article presents a review of the most relevant aspects of Roselle as well as its health benefits and its application in the food and beverage areas.

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Protective Role of Ethanolic Extract of Vernonia amygdalina Against Potassium Bromate Induced Tissue Damage in Wistar Rats

Cited by 10 publications

References 16 publications

ATPases in the colon of rats fed a Nigerian like diet supplemented with folate and bitter leaf (Vernonia amygdalina)

ATPases in the colon of rats fed a Nigerian like diet supplemented with folate and bitter leaf (Vernonia amygdalina)

Organic Acids from Roselle (Hibiscus sabdariffa L.)—A Brief Review of Its Pharmacological Effects

Roselle calyces (Hibiscus sabdariffa), an alternative to the food and beverages industries: a review

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