Protective role of dietary-supplemented selenium and vitamin E in heat-induced apoptosis and oxidative stress in mice testes

Kaur, Simranjit; Bansal, M. P.

doi:10.1111/and.12390

Cited by 43 publications

(31 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Selenium, a vital micronutrient, constitutes an essential component of GSH‐Px and selenoprotein P having ROS scavenging properties and can protect membrane lipids and macromolecules against oxidative damage. Accumulating evidences reveal that Se is required for maintenance of critical balance between germ cell death and proliferation during apoptosis in spermatogenesis (Kaur & Bansal, ; Wang et al., ).…”

Section: Discussionmentioning

confidence: 99%

“…Rayman () reviewed testis as a specific and privileged target of selenium that maintains normal spermatogenesis and male fertility. Se is proved to be beneficial in treating male infertility by improving sperm counts and motility through selenoproteins (Kaur & Bansal, ). In mammalian testis, the entire selenium content is associated with GSH‐Px selenoprotein and thus represents the crucial link between selenium, sperm quality and male fertility.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

2017

Self Cite

View full text Add to dashboard Cite

Spermatogenesis, a highly coordinated process, is prone to environmental insults which may lead to impaired spermatogenesis or, at worst, infertility. Bisphenol A (BPA) is a well-known global environmental toxicant and a ubiquitous oestrogenic chemical. This study evaluated the role of selenium (0.5 ppm sodium selenite/kg diet) on spermatogenesis after BPA treatment in different groups of male BALB/c mice: control, selenium, BPA and selenium+BPA. Markers of oxidative stress and apoptosis were evaluated in testis after BPA treatment. Significant decrease in sperm concentration and motility and increased reactive oxygen species(ROS) and LPO levels were seen in BPA group. Histopathological changes revealed extensive vacuolisation, lumen devoid of spermatozoa and decreased germ cell count, confirmed by testicular germ cell count studies. TUNEL assay for apoptosis showed increased number of TUNEL-positive germ cells in BPA group with increased percentage apoptotic index. However, in Se+BPA group, histopathological studies revealed systematic array of all germ cells, preserved basement membrane with relatively less vacuolisation, improved sperm parameters and ROS and LPO levels and decreased number of TUNEL-positive germ cells. These results clearly demonstrate the role of selenium in ameliorating oxidative stress and apoptosis induced upon BPA treatment in mice and can be further used as therapeutic target in male infertility.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…During reperfusion, nitric oxide (NO) and ROS production enhance germ cell‐specific necrosis. On the other hand, excessive generation of the ROS is tightly associated with the increased vulnerability of the cells to apoptosis (Kaur & Bansal, ; Mukherjee, Haldar, & Vishwas, ; Pazoki‐Toroudi, Ajami, et al., ; Pazoki‐Toroudi, Ajami, Babakoohi, et al., ). In present work, we evaluated the effect of capsaicin on pro‐apoptotic and anti‐apoptotic factors.…”

Section: Discussionmentioning

confidence: 99%

FOXO1 targeting by capsaicin reduces tissue damage after testicular torsion

et al. 2018

View full text Add to dashboard Cite

Testicular torsion-related oxidative stress causes a sequential chain of DNA damage, lipid peroxidation and cell death that leads to the derangement in the sperm functions and infertility. Capsaicin that has been applied for pain relief and cancer prevention possesses antioxidant properties which can be exploited to confer cell survival under ischaemic testis damage. Wistar male rats weighing 150-200 g were randomly divided into four groups: (i) sham group (all procedures except torsion of testis), (ii) ischaemia group (TT group), (iii) three TT groups treated with different dose of capsaicin (TT + different doses of Cap) and (iv) three control groups treated with different doses of capsaicin (100, 500 and 1000 ug/ml). Capsaicin administration significantly decreased the expression of pro-apoptotic factors and increased the expression of anti-apoptotic factors. Likewise, the expression of FOXO1 is significantly increased by higher doses of the capsaicin. Histological assessment by H&E and TUNEL method also exhibited an improved testicular morphology and decreased apoptosis in testes. These results suggested clinical potential for capsaicin in treatment of testicular torsion by targeting FOXO1 and apoptotic pathways.

show abstract

“…Recently, Erkekoglu et al (2012) reported that supplementation of Se to di(2-ethylhexyl) phthalate-treated rats lowered the activity of testicular germ cell apoptosis. In another study, a notable decrease in the apoptotic index of spermatogenic cells was recorded after scrotal hyperthermia in Se-supplemented mice (Kaur and Bansal, 2015).…”

Section: Discussionmentioning

confidence: 86%

Antioxidant activity of selenium on bisphenol-induced apoptosis and testicular toxicity of rats

Al-Amoudi¹

2018

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Bisphenol A (BPA) is an industrial chemical widely used to make polycarbonate plastics for packaging and epoxy resins. This study sought to examine how selenium (Se) affects BPA toxicity in terms of albino rats' histological structure, antioxidant enzymes, sexual hormones, and reproductive organs (seminiferous tubule (coiled tubule) diameter, epithelial height and sperm count). Adult male rats were divided into four experimental groups: Group 1: The control; Group 2: Orally administered sodium selenite (10 μg/kg bw/day) for 4 weeks; Group 3: Orally administered BPA (10 μg/kg bw/day) for 4 weeks; Group 4: Treated daily with BPA (10 μg/kg bw/day) followed by Se (orally administered, 10 μg/kg bw/day) for 5 times per 4 weeks. BPA exposure caused changes in the testicular histological structure, which included apoptosis, and led to changes in several biochemical markers: Malondialdehyde, catalase, superoxide dismutase, and glutathione peroxidase. Additional changes occurred in the plasma testosterone, luteinizing hormone, and follicle-stimulating hormone levels, body and reproductive organ weights, and sperm counts. However, these BPA-induced effects were significantly ameliorated in rats treated with BPA-plus-Se. This protective effect of Se is attributable to its ability to remove potentially damaging oxidizing agents in living organisms. The results confirmed that Se countered the oxidant effects and increased the BPA-induced stress response in rats. Hence, Se promotes the healthy growth and development of mammals by protecting them from oxidative stress.

show abstract

Protective role of dietary-supplemented selenium and vitamin E in heat-induced apoptosis and oxidative stress in mice testes

Cited by 43 publications

References 61 publications

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

Bisphenol A induced oxidative stress and apoptosis in mice testes: Modulation by selenium

FOXO1 targeting by capsaicin reduces tissue damage after testicular torsion

Antioxidant activity of selenium on bisphenol-induced apoptosis and testicular toxicity of rats

Contact Info

Product

Resources

About