Protective Role of Dietary Capsanthin in a Mouse Model of Nonalcoholic Fatty Liver Disease

Joo, Hee Kyoung; Lee, Yu Ran; Lee, Eun-Ok; Kim, Sung-Min; Jin, Hao; Kim, Suna; Lim, Yong Pyo; An, Chul Geon; Jeon, Byeong Hwa

doi:10.1089/jmf.2020.4866

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…To examine the role of capsanthin, capsanthin (0.5 mg/kg of body weight/day) was orally administered to ApoE −/− mice daily. The capsanthin dose used corresponded to the dose that inhibits nonalcoholic fatty liver disease in mice [ 32 ]. The lipid-lowering agent, atorvastatin (20 mg/kg of body weight/day), was orally administered to ApoE −/− mice daily.…”

Section: Resultsmentioning

confidence: 99%

“…Based on body surface area conversion, 0.5 mg/kg of capsanthin in mice equals 0.041 mg/kg of capsanthin in humans [ 48 ]. In a previous study, the capsanthin content in Raon red paprika was 34.33 mg/100 g dry weight [ 32 ]. For a similar anti-arteriosclerosis effect, capsanthin content was converted to 72 g of red paprika per day for a person weighing 60 kg.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the antioxidant potential of capsanthin, previous studies have reported its antitumor, skin photoprotective, antidiabetic, and anti-obesity activities in in vitro and in vivo models [ 29 , 30 , 31 ]. We have previously reported the protective effect of capsanthin in a mouse model of nonalcoholic fatty liver disease [ 32 ]. However, the role of capsanthin in atherosclerosis remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE−/− Mice

Kim

Lee

et al. 2022

Biomedicines

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Capsanthin is a red pigment and the major carotenoid component of red paprika (Capsicum annuum L.). However, its role in atherosclerosis is yet to be fully elucidated. This study investigated the role of dietary capsanthin in vascular inflammation in atherosclerotic mice. We evaluated the anti-atherosclerotic effects of daily oral administration of capsanthin (0.5 mg/kg of body weight/day) in apolipoprotein E-deficient (ApoE−/−) mice fed a Western-type diet (WD). Capsanthin treatment inhibited vascular cell adhesion molecule 1 expression and nuclear factor-κB ser536 phosphorylation in tumor necrosis factor-α-stimulated cultured endothelial cells. Dietary capsanthin significantly inhibited the WD-induced elevation in the plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride in mice. Interestingly, capsanthin reduced aortic plaque formation and VCAM-1 expression, which is vascular inflammation, in atherosclerotic mice. In addition, the neutrophil–lymphocyte ratio, a systemic inflammatory marker, was inhibited in capsanthin-treated mice. Furthermore, capsanthin significantly reduced the levels of proinflammatory cytokines, such as TNF-α, interleukin-6, and monocyte chemoattractant protein-1, in the plasma of atherosclerotic mice. Collectively, our data demonstrate that dietary capsanthin plays a protective role against atherosclerosis in hyperlipidemic mice. This protective effect could be attributed to the anti-inflammatory properties of capsanthin.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE−/− Mice

Kim

Lee

et al. 2022

Biomedicines

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Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats

et al. 2023

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Identification of hepatoprotective traditional Chinese medicines based on the structure–activity relationship, molecular network, and machine learning techniques

Hou

et al. 2022

Front. Pharmacol.

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The efforts focused on discovering potential hepatoprotective drugs are critical for relieving the burdens caused by liver diseases. Traditional Chinese medicine (TCM) is an important resource for discovering hepatoprotective agents. Currently, there are hundreds of hepatoprotective products derived from TCM available in the literature, providing crucial clues to discover novel potential hepatoprotectants from TCMs based on predictive research. In the current study, a large-scale dataset focused on TCM-induced hepatoprotection was established, including 676 hepatoprotective ingredients and 205 hepatoprotective TCMs. Then, a comprehensive analysis based on the structure–activity relationship, molecular network, and machine learning techniques was performed at molecular and holistic TCM levels, respectively. As a result, we developed an in silico model for predicting the hepatoprotective activity of ingredients derived from TCMs, in which the accuracy exceeded 85%. In addition, we originally proposed a material basis and a drug property-based approach to identify potential hepatoprotective TCMs. Consequently, a total of 12 TCMs were predicted to hold potential hepatoprotective activity, nine of which have been proven to be beneficial to the liver in previous publications. The high rate of consistency between our predictive results and the literature reports demonstrated that our methods were technically sound and reliable. In summary, systematical predictive research focused on the hepatoprotection of TCM was conducted in this work, which would not only assist screening of potential hepatoprotectants from TCMs but also provide a novel research mode for discovering the potential activities of TCMs.

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Protective Role of Dietary Capsanthin in a Mouse Model of Nonalcoholic Fatty Liver Disease

Cited by 4 publications

References 47 publications

Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE−/− Mice

Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE−/− Mice

Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats

Identification of hepatoprotective traditional Chinese medicines based on the structure–activity relationship, molecular network, and machine learning techniques

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