Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats

Singh, Jaswant; Selvendiran, K.; Banu, Syed Mumtaz; Padmavathi, R.; Sakthisekaran, Dhanapal

doi:10.1078/0944711041495254

Cited by 132 publications

(43 citation statements)

References 40 publications

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confidence: 94%

“…The results showed that the antioxidant activity of the plant extract and isolated compounds have the following order: methanol extract > compound 1 > compound 2 > compound 3 > compound 4 (l " Table 1). Our results confirmed the antioxidant potential of rutin and apigenin, whose antioxidant activities were reported previously [8,9]. Based on these data, it can be concluded that compounds 1 and 2 exhibited the most potent antioxidant activity, with an IC 50 of 22.6 ± 1.1 and 26.14 ± 1.52, respectively, near to butylated hydroxytoluene (BHT) as a positive control (IC 50 of 18.42 ± 1.21).…”

supporting

confidence: 93%

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Antioxidant and Protective Effects of Major Flavonoids fromTeucrium poliumonβ-Cell Destruction in a Model of Streptozotocin-Induced Diabetes

Esmaeili¹,

Zohari²,

Sadeghi³

2009

Planta Med

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The hypoglycemic effect of Teucrium polium has been accounted for by its constituents that increase insulin release. The present study aimed to investigate whether the major flavonoid compounds (rutin and apigenin) from the methanol extract of Teucrium polium would stimulate insulin secretion and, if so, to further elucidate the mechanism behind this effect. Isolated rat pancreatic islets were batch incubated to study the effect of rutin and apigenin on insulin secretion at various glucose concentrations. Treated islets in the presence of streptozotocin (STZ) and flavonoid compounds significantly increased insulin release by almost 56 % compared with STZ-treated islets. Our data indicated that the flavonoids in T. polium extract appeared to be helpful in protecting pancreatic islets against exposure to STZ in vitro due to their antioxidant activity.

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supporting

confidence: 94%

supporting

confidence: 93%

Antioxidant and Protective Effects of Major Flavonoids fromTeucrium poliumonβ-Cell Destruction in a Model of Streptozotocin-Induced Diabetes

Esmaeili¹,

Zohari²,

Sadeghi³

2009

Planta Med

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“…A significant number of flavones were also identified, indicative of the presence of rutin in C. comatus M8102 extract and also the lack of catechin, except for the P. ostreatus PQMZ91109 mycelium extract. Another novel finding was the presence of apigenin (0.034 ± 0.00 mg/100 g extract) in the C. comatus M8102 extract, which is responsible for the inhibition of membrane lipid peroxidation [20]. An additional finding as a result of the chromatographic analysis was the identification of pyrogallol in the P. ostreatus PBS281009 mycelium extract, which has not been identified for this species in previous studies [19].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Properties of Mushroom Mycelia Obtained by Batch Cultivation and Tocopherol Content Affected by Extraction Procedures

Vamanu

2014

BioMed Research International

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The determination of the antioxidant potential of lyophilized mushroom mycelia from 5 strains of the species Pleurotus ostreatus and Coprinus comatus (obtained by submerged cultivation in batch system) was analyzed as ethanolic extracts by evaluating ABTS and the hydroxyl scavenging activity, FRAP method, the chelating capacity, the inhibition of human erythrocyte hemolysis, and the inhibition of xanthine oxidase activity. The main compounds present in all extracts were determined by HPLC chromatography. Overall, results demonstrated that the biologically active substances content is modulated by the extraction method used. The most beneficial extract, characterized by determining the EC50 value, was that of C. comatus M8102, followed by P. ostreatus PQMZ91109. Significant amount of α-tocopherol (179.51 ± 1.51 mg/100 g extract) was determined as well as flavones such as rutin and apigenin. In the P. ostreatus PQMZ91109 extract, 4.8 ± 0.05 mg/100 g extract of tocopherol acetate known to play a significant role as an antioxidant in skin protection against oxidative stress generated by UV rays was determined. The various correlations (r 2 = 0.7665–0.9426 for tocopherol content) assessed and the composition of extracts in fluidized bed from the mycelia of the tested species depicted a significant pharmacological potential as well as the possibility of usage in the development of new functional products.

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“…Prime cancers. [20] Serum MDA levels were significantly elevated in liver cancer induced groups when compared to controls.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

ANTIPROLIFERATIVE ACTIVITY OF QUERCETIN ON HepG2 CELL LINE INDUCED LIVER CANCER IN RATS

Rani¹

2017

WJPPS

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The wide use of natural food-derived antioxidants is receiving greater attention as potential anti-carcinogens. Among flavonoids, Quercetin is considered an excellent free-radical scavenging antioxidant. In present study antiproliferative activity of Quercetin was evaluated on HepG2 cell line induced liver cancer in rats. For the purpose of this study, 30 rats were divided into 5 groups and each group containing 6 rats each.

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Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats

Cited by 132 publications

References 40 publications

Antioxidant and Protective Effects of Major Flavonoids fromTeucrium poliumonβ-Cell Destruction in a Model of Streptozotocin-Induced Diabetes

Antioxidant and Protective Effects of Major Flavonoids fromTeucrium poliumonβ-Cell Destruction in a Model of Streptozotocin-Induced Diabetes

Antioxidant Properties of Mushroom Mycelia Obtained by Batch Cultivation and Tocopherol Content Affected by Extraction Procedures

ANTIPROLIFERATIVE ACTIVITY OF QUERCETIN ON HepG2 CELL LINE INDUCED LIVER CANCER IN RATS

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