Protective response of Sestrin under stressful conditions in aging

Rai, Nitish; Dey, Sharmistha

doi:10.1016/j.arr.2020.101186

Cited by 16 publications

(26 citation statements)

References 83 publications

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“…Meanwhile, they found no significant correlations between serum sestrin2 levels and BMI as well as SBP, DBP, total cholesterol, LDL‐C, HDL‐C, FBS, and HbA1c in individuals with normal glucose tolerance 45 . A possible explanation for this paradoxical increase in serum sestrin2 in subjects with metabolic syndrome might be a compensatory mechanism to overcome the metabolic stress or resistance to sestrin2 41,45 . In the current study, we did not find any significant correlation between sestrin2 and anthropometric characteristics including BMI, indicating that the reduced level of sestrin2 may not be a consequence of obesity.…”

Section: Discussioncontrasting

confidence: 72%

“…As mentioned before, we found that plasma levels of sestrin2 in patients with PCOS were significantly lower than those in the healthy controls. Interestingly, this finding contradicts some of the previous research on cardiovascular and pulmonary diseases, cancer, and neurodegenerative disorders which found an increase in the circulating sesrin2 levels in the patients 40,41 . It has been suggested that induction of sestrin2 in these diseases protects against damage associated with different stress conditions 41 .…”

Section: Discussionmentioning

confidence: 63%

“…Elevated plasma levels of sestrin2 in different malignancies such as lung and colorectal cancers suggest a tumor‐suppressive role for this protein 50,51 . Moreover, significantly increased serum levels of sestrin2 have been demonstrated in Parkinson's disease and Alzheimer's disease, with a significant negative correlation with the mental and cognitive state 41,52,53 . Considering the role of oxidative stress and the accumulation of aberrantly processed or misfolded proteins in the pathogenesis of neurodegenerative disorders, the protective enhancement of sestrin2 is a plausible mechanism due to its role in antioxidative defense and promotion of autophagy 41,54 .…”

Section: Discussionmentioning

confidence: 99%

“…A number of previous studies have examined circulating concentrations of sestrin2 in several human diseases, 40,41 but to date, none has evaluated the plasma levels of this protein in patients with PCOS. Lee et al found that sestrin2 deficiency enhances insulin resistance, glucose intolerance, oxidative stress, and progression of type 2 diabetes in obese mice kept on high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

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Sestrin2 and Beclin1 levels in Polycystic Ovary Syndrome

Saeedi

Nourbakhsh

et al. 2021

Clinical Laboratory Analysis

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Background Sestrin2 and beclin1 are two newly found proteins that have essential roles in autophagy. This study attempted to evaluate the plasma concentrations of sestrin2 and beclin1 in women with polycystic ovary syndrome (PCOS) and healthy controls and to explore the clinical value of these proteins as novel biomarkers for PCOS. Methods In this case‐control study, plasma levels of sestrin2 and beclin1, fasting blood sugar (FBS), lipid profile, insulin, and androgens were evaluated in 63 women (31 patients and 32 controls). Sestrin2 and beclin1 levels were determined using enzyme‐linked immunosorbent assay (ELISA). Descriptive statistics, correlation coefficients, logistic regression, and ROC curve analyses were used in this study. Results Plasma sestrin2 levels of the subjects with PCOS (40.74 [24.39–257.70]) were significantly lower than those of healthy subjects (255.78 [25.46–528.66]; p‐value = 0.040). ROC curve analysis showed that a cutoff value of 420.5 ng/L had an appropriate sensitivity (83.87%) and specificity (46.88%) for discriminating individuals with and without PCOS, with the area under the curve (95% CI) of 0.648 (0.518 to 0.764), p = 0.036. There were no statistically significant differences between the two groups concerning plasma levels of beclin1, biochemical parameters, blood pressure, and anthropometric features. Conclusion Our findings highlight the dysregulation of sestrin2 as a marker of autophagy in PCOS and its potential usefulness as a novel biomarker for PCOS. Further research is needed to better understand the role of this protein in the pathophysiology of PCOS and its value as a diagnostic tool for the evaluation of PCOS patients.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sestrin2 and Beclin1 levels in Polycystic Ovary Syndrome

Saeedi

Nourbakhsh

et al. 2021

Clinical Laboratory Analysis

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“…As a result, the number of damaged mitochondria increases, which in turn stimulates the accumulation of ROS, contributing to further cell damage [29,33,37]. Together, increased metabolic activity, impaired mitochondrial function, insufficient concentration of protective redox molecules (e.g., H 2 S), and inflammation prompt high spending of NAD+ and ROS accumulation [85,86,261]. These events of cellular aging further trigger advanced pathological processes, accumulation of senescent cells, and development of age-related disorders [262].…”

Section: Regeneration and Metabolic Disordersmentioning

confidence: 99%

Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

et al. 2020

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According to the World Health Organization, the population of over 60 will double in the next 30 years in the developed countries, which will enforce a further raise of the retirement age and increase the burden on the healthcare system. Therefore, there is an acute issue of maintaining health and prolonging active working longevity, as well as implementation of early monitoring and prevention of premature aging and age-related disorders to avoid early disability. Traditional indicators of biological age are not always informative and often require extensive and expensive analysis. The study of blood factors is a simple and easily accessible way to assess individual health and supplement the traditional indicators of a person’s biological age with new objective criteria. With age, the processes of growth and development, tissue regeneration and repair decline; they are gradually replaced by enhanced catabolism, inflammatory cell activity, and insulin resistance. The number of senescent cells supporting the inflammatory loop rises; cellular clearance by autophagy and mitophagy slows down, resulting in mitochondrial and cellular damage and dysfunction. Monitoring of circulated blood factors not only reflects these processes, but also allows suggesting medical intervention to prevent or decelerate the development of age-related diseases. We review the age-related blood factors discussed in recent publications, as well as approaches to slowing aging for healthy and active longevity.

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