Protective properties of chlorocresacine against adverse impact of electromagnetic radiation

Воронков, М. Г.; Sofronov, G. A.; Starchenko, D. A.; Адамович, С. Н.; Мирскова, А. Н.

doi:10.1134/s0012496609050020

Cited by 16 publications

(4 citation statements)

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“…The ADME analysis was applied to evaluate the drug-likeness properties of new ILs based on BEA salts 1 – 16 . For comparison, two biologically active compounds trekrezan and chlorcrezacin [ 38 , 39 , 40 , 41 , 42 , 43 ], which are TEA 2-methylphenoxyacetate 2-methyl-4-chlorophenoxyacetate, respectively, were used. In silico, some ADME physicochemical properties were predicted and presented in Table 5 .…”

Section: Resultsmentioning

confidence: 99%

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N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals

et al. 2023

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Ionic liquids (ILs), due to their structural features, have unique physical and chemical properties and are environmentally friendly. Every year, the number of studies devoted to the use of ILs in medicine and pharmaceutics is growing. In nuclear medicine, the use of ILs with self-buffering capacity in the synthesis of radiopharmaceuticals is extremely important. This research is devoted to obtaining new ionic buffer agents containing N-benzylethanolammonium (BEA) cations and anions of carboxylic acids. A series of new BEA salts was synthesized and identified by NMR (1H, 13C), IR spectroscopy and elemental and thermal analysis. The crystal structures of BEA hydrogen succinate, hydrogen oxalate and oxalate were determined by x-ray diffraction. Newly synthesized compounds were tested as buffer solutions in 68Ga- and Al18F-radiolabeling reactions with a series of bifunctional chelating agents and clinically relevant peptides used for visualization of malignancies by positron emission tomography. The results obtained confirm the promise of using new buffers in the synthesis of 68Ga- and Al18F-labeled radiopharmaceuticals.

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Section: Resultsmentioning

confidence: 99%

“…It should be noted that some alkanolammonium ILs are drugs with immunomodulatory and adaptogenic properties and are widely used in medicine, pharmaceuticals, biotechnology and agriculture [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals

et al. 2023

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“…Chlorocrezacin prevents the neural activity disorders under the impact of microwave irradiation. Antioxidant activity can be regarded among possible mechanisms of protective action of chlorocrezacin [ 53 ].…”

Section: Protatranesmentioning

confidence: 99%

Contribution of the Scientific School of Academician M.G. Voronkov to the Development of the Chemistry of Biologically Active Atranes (Protatranes and Hydrometallatranes) (A Review)

Kondratenko

Кочина

2021

Russ J Gen Chem

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The main results of the many years’ studies of the scientific school of Academician Mikhail G. Voronkov in the field of two subgroups of the atrane family (protatranes and hydrometallatranes) as well as the results of research in continuation of the studies initiated by Academician M. G. Voronkov have been summarized and presented. Long-term studies of atranes under the leadership of M. G. Voronkov have led to the discovery of their unique biological activity and the creation of a series of unique original drugs and means of agricultural chemicalization: biostimulants and adaptogens for agricultural plants, animals, useful insects and microorganisms.

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“…They are the pharmacologically active substances of low toxicity (LD 50 1300-6000 mg kg -1 ) possessing anti-aggregatory, membrane stabilizing, anti-sclerotic, immunomodulatory, antitumor, adaptogenic, and other activities [1][2][3][4][5][6][7].…”

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confidence: 99%

Protic ionic liquids based on 1,1-dimethylhydrazine and arylheteroacetic acids

et al. 2012

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Protective properties of chlorocresacine against adverse impact of electromagnetic radiation

Cited by 16 publications

References 4 publications

N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals

N-Benzylethanolammonium Ionic Liquids and Molten Salts in the Synthesis of 68Ga- and Al18F-Labeled Radiopharmaceuticals

Contribution of the Scientific School of Academician M.G. Voronkov to the Development of the Chemistry of Biologically Active Atranes (Protatranes and Hydrometallatranes) (A Review)

Protic ionic liquids based on 1,1-dimethylhydrazine and arylheteroacetic acids

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