Protective Potential effect of <i>Gloriosa superba</i> Linn. against lead Nitrate Induced Oxidative stress in Rats.

Umarani, V; Sudhakar, M.; Ramesh, Alluri

doi:10.5958/2231-5659.2019.00029.8

Cited by 6 publications

(1 citation statement)

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“…Antioxidant properties of polysaccharide peptide of G. lucidum include free radicals scavenging activity 20 . Antioxidant is a compound capable of neutralizing reactive free radicals into relatively stable nonreactive forms to protect the cells from harmful effects of free radicals and can be used for the treatment of liver injury and other diseases 21,22 .…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H₂O₂ Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Wihastuti¹,

Cesa²,

Amiruddin³

et al. 2020

Rese. Jour. of Pharm. and Technol.

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Dyslipidemia is one of risk factors for atherosclerosis induced by high fat diet. In atherosclerosis, an angiogenesis of immature and fragile vasa vasorum leads to atherosclerotic plaque destabilization. Angiogenesis of vasa vasorum is influence by oxidative stress and inflammation. Polysaccharide peptide (PsP) from Ganoderma lucidum (GL) contains bioactive compounds that possess antioxidant and anti-inflammatory properties which might become anti-angiogenesis agent in atherosclerosis. The aim of this study is to determine whether administration of PsP GL is able to decrease the number of vasa vasorum, H2O2 and Lp-PLA2 in atherosclerosis mouse model with dyslipidemia. True Experimental research design was conducted with Randomized Post Test Only Controlled Group Design. Twenty five Wistar strain Rattus novergicus were divided into 5 groups (n=5). Negative control group was administered with normal diet, positive control group was given high fat diet (HFD), and 3 treatment groups received HFD and PsP administration of 50mg/kgBW, 150 mg/kgBW, and 300mg/kgBW. Vasa vasorum measurement was performed using histopathological section of mouse aorta and measured using Scan Dot Slide Olyvia with 400x magnification. Serum Lp-PLA2 and H2O2 were measured using ELISA method. One way ANOVA analysis demonstrates that PsP GL significantly reduced vasa vasorum count (p<0,05) in mouse model of atherosclerosis with dyslipidemia. Duncan Post Hoc analysis indicates a significant difference in vasa vasorum count in 50mg/kgBW PsP treated group compared to other doses. The conclusions of this study is Polysaccharid peptide G. lucidum extract significantly reduces vasa vasorum count in Wistar strain Rattus novergicus with HFD administration.

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Section: Introductionmentioning

confidence: 99%

Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H₂O₂ Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Wihastuti¹,

Cesa²,

Amiruddin³

et al. 2020

Rese. Jour. of Pharm. and Technol.

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Effect of Gloriosa superba linn (EEGS) on mPT and monosodium glutamate-induced proliferative disorder using rat model

Olowofolahan

Olorunsogo

2021

Journal of Ethnopharmacology

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Exploring the effect of Naringenin against Cadmium Induced Neurotoxicity in mice model

Srivastava

Awasthi

Srivastava

et al. 2021

RJPT

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Bioactive flavonoid Naringenin has very high nutritional value. Several investigations suggested that supplementation of this bioactive flavonoid is beneficial for health. Naringenin have been found in variety of herbs and fruits which are used for daily consumption like citrus species, tomatoes and figs. This study aimed to explore the effect of flavonoid naringenin on oxidative damage, memory impairment and cholinergic dysfunction induced by Cadmium chloride (5mg/kg p.o) in mice. In this experiment naringenin (20 and 40 mg/kg, p.o.) was given orally for the duration of 28 days in Swiss mice. Memory function was assessed by using elevated plus maze test and morris water maze. Cholinergic function and oxidative stress were estimated in brain homogenate after behavioral study. It was found that naringenin improved memory impairment in cadmium chloride treated mice. Naringenin increases the level of reduced glutathione (GSH) and decreases the level of malondialdehyde (MDA) in brain, helps in memory improvement and decrease oxidative stress.

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Protective Potential effect of Gloriosa superba Linn. against lead Nitrate Induced Oxidative stress in Rats.

Cited by 6 publications

References 0 publications

Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H₂O₂ Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H₂O₂ Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Effect of Gloriosa superba linn (EEGS) on mPT and monosodium glutamate-induced proliferative disorder using rat model

Exploring the effect of Naringenin against Cadmium Induced Neurotoxicity in mice model

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Protective Potential effect of Gloriosa superba Linn. against lead Nitrate Induced Oxidative stress in Rats.

Cited by 6 publications

References 0 publications

Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H2O2 Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H2O2 Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Effect of Gloriosa superba linn (EEGS) on mPT and monosodium glutamate-induced proliferative disorder using rat model

Exploring the effect of Naringenin against Cadmium Induced Neurotoxicity in mice model

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Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H₂O₂ Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H₂O₂ Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia