Effect of Gloriosa superba linn (EEGS) on mPT and monosodium glutamate-induced proliferative disorder using rat model

Olowofolahan, Adeola Oluwakemi; Olorunsogo, Olufunso O.

doi:10.1016/j.jep.2020.113498

Cited by 4 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the undisputed activity of the phenethylisoquinoline alkaloids, major secondary metabolites, and also peptides obtained from the rhizome of G. superba are investigated against colon cancer [ 84 ]. In vivo study suggests that ethanol leaf extract of G. superba contains phytochemicals that can induce apoptosis via mitochondrial permeability transition pore opening and protect against monosodium glutamate-induced hepato-cellular injury and proliferative disorder in prostate and uterus [ 142 ]. Partially purified protein hydrolysate (30 ng/mL) significantly inhibited viability (by 40%) of SW620 human colon cancer cells and induced apoptosis by the up-regulation of p53 and down-regulation of NF-kB, considered potential targets for anticancer therapy.…”

Section: Resultsmentioning

confidence: 99%

Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus Astragalus L. and Gloriosa L.

Йонкова

Shkondrov

Zarev

et al. 2022

CIMB

View full text Add to dashboard Cite

Some of the most effective anticancer compounds are still derived from plants since the chemical synthesis of chiral molecules is not economically efficient. Rapid discovery of lead compounds with pronounced biological activity is essential for the successful development of novel drug candidates. This work aims to present the chemical diversity of antitumor bioactive compounds and biotechnological approaches as alternative production and sustainable plant biodiversity conservation. Astragalus spp., (Fabaceae) and Gloriosa spp. (Liliaceae) are selected as research objects within this review because they are known for their anticancer activity, because they represent two of the largest families respectively in dicots and monocots, and also because many of the medicinally important plants are rare and endangered. We summarized the ethnobotanical data concerning their anticancer application, highlighted the diversity of their secondary metabolites possessing anticancer properties such as saponins, flavonoids, and alkaloids, and revealed the potential of the in vitro cultures as an alternative way of their production. Since the natural supply is limited, it is important to explore the possibility of employing plant cell or organ in vitro cultures for the biotechnological production of these compounds as an alternative.

show abstract

Section: Resultsmentioning

confidence: 99%