Protective Potencial of Euphorbia hirta Against Cytotoxicity-Induced in Hepatocytes and a Hepg2 Cell Line

Brindha, D; Seethapathy, Gopalakrishnan Saroja; Jeyanthi, GP

doi:10.1515/jbcpp.2010.21.4.401

Cited by 15 publications

(8 citation statements)

References 8 publications

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“…Moreover, it was the only extract that was found to have exhibited its effect in a concentration dependent fashion with the highest concentration having the least inhibitory effect. This observation is in agreement with that of Brindha et al (2010) who observed a dose-dependent increase in viability when antitubercular drug exposed human liver derived HepG2 cells were treated with different concentrations of extracts of the plant [44]. …”

Section: Discussionsupporting

confidence: 92%

Extracts of Euphorbia hirta Linn. (Euphorbiaceae) and Rauvolfia vomitoria Afzel (Apocynaceae) demonstrate activities against Onchocerca volvulus Microfilariae in vitro

Attah

Ayeh‐Kumi

Sittie³

et al. 2013

BMC Complement Altern Med

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BackgroundOnchocerciasis transmitted by Onchocerca volvulus is the second major cause of blindness in the world and it impacts negatively on the socio-economic development of the communities affected. Currently, ivermectin, a microfilaricidal drug is the only drug recommended for treating this disease. There have been speculations, of late, concerning O. volvulus resistance to ivermectin. Owing to this, it has become imperative to search for new drugs. World-wide, ethnomedicines including extracts of Euphorbia hirta and Rauvolfia vomitoria are used for treating various diseases, both infectious and non-infectious.MethodIn this study extracts of the two plants were evaluated in vitro in order to determine their effect against O. volvulus microfilariae. The toxicity of the E. hirta extracts on monkey kidney cell (LLCMK2) lines was also determined.ResultsThe investigations showed that extracts of both plants immobilised microfilariae at different levels in vitro and, therefore, possess antifilarial properties. It was found that all the E. hirta extracts with the exception of the hexane extracts were more effective than those of R. vomitoria. Among the extracts of E. hirta the ethyl acetate fraction was most effective, and comparable to that of dimethanesulphonate salt but higher than that of Melarsoprol (Mel B). However, the crude ethanolic extract of E. hirta was found to be the least toxic to the LLCMK2 compared to the fractionated forms.ConclusionsExtracts from both plants possess antifilarial properties; however, the crude extract of E. hirta was found to be least toxic to LLCMK2.

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Section: Discussionsupporting

confidence: 92%

Extracts of Euphorbia hirta Linn. (Euphorbiaceae) and Rauvolfia vomitoria Afzel (Apocynaceae) demonstrate activities against Onchocerca volvulus Microfilariae in vitro

Attah

Ayeh‐Kumi

Sittie³

et al. 2013

BMC Complement Altern Med

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“…A significant enhancement of mean survival time and reduction of solid tumor mass of EF-treated tumor-bearing mice was observed (Sandeep and Chandrakant, 2011). The methanol extract of the leaves of E. hirta on Hep-2 cells from human epithelioma of the larynx showed anti-proliferative activity (Brindha et al, 2010). Daphne et al (2009) evaluated the mutagenic and antimutagenic activities of the aqueous and methanolic extracts and quercetin from E. hirta.…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Euphorbia hirta (Feiyangcao): A review on its ethnopharmacology, phytochemistry and pharmacology

Huang¹,

Chen²,

Yang³

2012

J. Med. Plants Res.

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A bibliographic investigation was carried out by gathering and analyzing the recognized books, including Chinese herbal classic, the Internet (Google Scholar, Baidu Scholar), and scientific databases (Pubmed, Scifinder, Scopus, CNKI, ACS, and Web of Science) for available information on Euphorbia hirta. Whole plants of E. hirta have been used in traditional Chinese medicine (TCM) due to its properties that can cure and detoxify fever, promote diuresis, stop itching, and induce prolactin. Traditional uses of E. hirta are also recorded in some other pan-tropical areas, where it has been used for over 10 types of diseases. A number of chemical constituents, including flavonoids, terpenoids and phenols, have been isolated and identified from E. hirta. Various biological evaluations have been reported for its importance. Modern pharmacological investigation demonstrated that its crude extracts and active compounds possesses wide pharmacological effects, such as antibacterial, anti-inflammatory, antioxidant, sedative and anti-allergy. The current study summarizes the updated information concerning the ethnopharmacology, phytochemistry, and pharmacology of E. hirta as well as its toxicology, and discusses the existing problem and future research direction of E. hirta.

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“…Medicinal plants play a key role in human health care. Nullification the side effects of allopathic drugs has driven the medical world to take sanctuary in the plant kingdom for the treatment of various diseases [29]. The current study has been planned to study whether Pomegranate and milk thistle supplementation could prevent the development of hepatic carcinogenesis both in vitro and in vivo using chemical induction for hepatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Chemopreventive Efficacy of <i>Punica granatum</i> and <i>Silybum marianum </i>Extracts on Chemically-induced Hepatocellular Carcinoma in Rats

Tag

Bargougui²,

Alshayyal³

et al. 2019

AJAS

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Punica granatum (POM) and Silybum marianum (MT) receiving attention as potential potent anti-oxidant and anti-mutant agents. In this context, the present study was designed to highlight their effects either in vitro as well as in vivo model of induced Hepatocellular carcinoma (HCC). Human hepatoma (HepG2 cells) were treated with MT and POM to explore their antitumor activity then in vivo were carried out on thirty-six male albino rats divided into six groups (n=6). Two weeks after induction of HCC, rats were co-treated with either MT or POM ethanolic extract (500 mg/kg, orally) daily for 8 weeks. The results displayed marked reduction in the viability of HepG2 cells with IC50 equal to 48.4 and 8.6 Î¼g/mL of POM and MT treatment respectively. Considering, in vivo experiment HCC group displayed significant elevation liver function indices (p<0.05). It also elicited depletion of liver reduced glutathione (GSH), and increased content of liver malondialdehyde (MDA) compared to control group. HCC was proved after a significantly elevated alpha-fetoprotein (AFP) level (p<0.05). All of these measurements were diminished significantly after POM and MT treatments, except the GSH level that was increased significantly. Supplementation of pomegranate and milk thistle extracts had a protective effect against chemically induced HCC.Â

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Protective Potencial of Euphorbia hirta Against Cytotoxicity-Induced in Hepatocytes and a Hepg2 Cell Line

Cited by 15 publications

References 8 publications

Extracts of Euphorbia hirta Linn. (Euphorbiaceae) and Rauvolfia vomitoria Afzel (Apocynaceae) demonstrate activities against Onchocerca volvulus Microfilariae in vitro

Extracts of Euphorbia hirta Linn. (Euphorbiaceae) and Rauvolfia vomitoria Afzel (Apocynaceae) demonstrate activities against Onchocerca volvulus Microfilariae in vitro

Euphorbia hirta (Feiyangcao): A review on its ethnopharmacology, phytochemistry and pharmacology

Chemopreventive Efficacy of <i>Punica granatum</i> and <i>Silybum marianum </i>Extracts on Chemically-induced Hepatocellular Carcinoma in Rats

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