Protective mechanism of selenium on mercuric chloride-induced testis injury in chicken via p38 MAPK/ATF2/iNOS signaling pathway

Chen, Xuewei; Chu, Jia-Hong; Li, Lanxin; Gao, Pei-Chao; Wang, Zhenyong; Fan, Rui-Feng

doi:10.1016/j.theriogenology.2022.05.007

Cited by 18 publications

(4 citation statements)

References 41 publications

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“…Oxidative stress refers to the imbalance of oxidation and antioxidation in the body, the increase of oxygen free radicals or the decrease of the ability to clear free radicals 13,14 . The common oxidative stress parameters was malondialdehyde (MDA), and antioxidant parameters were catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD), and total antioxidant capacity (T‐AOC), and the increase of reactive oxygen species (ROS) content could also be used as an auxiliary index of oxidative stress 15,16 . The toxic mechanism of environmental stressors on aquatic organisms is oxidative stress 17 .…”

Section: Introductionmentioning

confidence: 99%

“…13,14 The common oxidative stress parameters was malondialdehyde (MDA), and antioxidant parameters were catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC), and the increase of reactive oxygen species (ROS) content could also be used as an auxiliary index of oxidative stress. 15,16 The toxic mechanism of environmental stressors on aquatic organisms is oxidative stress. 17 Studies have shown that exposure to heavy metal manganese can induce oxidative stress and neuroinflammation in the hippocampus of adult mice.…”

Section: Introductionmentioning

confidence: 99%

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Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

Chen

Zhang

et al. 2023

Environmental Toxicology

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Di(2‐ethylhexyl) phthalate (DEHP) is a plasticizer and an endocrine disruptor. Microplastics (MPs) are pathogenic small plastic particles and abundant in the aqueous environment. The problem of residual hazards of plastic products is worthy of study, especially the joint exposure of a variety of plastic‐related products to the toxic effect. We used 200 mg/kg DEHP and 10 mg/L MPs to establish exposure model in vivo and 2 mM DEHP and 200 μg/L MPs to establish AML12 cell exposure model in vitro. In vivo study results showed that compared with the control group (NC) group, DEHP and MPs significantly increased the contents of malondialdehyde and hydrogen peroxide, and significantly decreased the contents of glutathione and the activity of superoxide dismutase, total antioxidant capacity, catalase and glutathione peroxidase. The level of oxidative stress was further aggravated after combined exposure. The reactive oxygen species level of AML12 exposed to DEHP and MPs in vitro was significantly higher than NC group, and the combined exposure was significantly higher than the single exposure. The in vivo and in vitro also confirmed that DEHP and MPs could significantly increase the mRNA and protein levels of apoptosis markers and necroptosis markers and there was an additive effect. After N‐acetylcysteine treatment in vitro, the above‐mentioned oxidative stress level and cell damage decreased significantly. This study provided a reference for advocating the reduction of the mixed use of plastic products, and provided a basis for preventing the harm of plastic products residues.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

Chen

Zhang

et al. 2023

Environmental Toxicology

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“…As a result of their antioxidant, antiinflammatory, and anti-apoptotic properties, several natural and synthetic substances have been explored for their probable action to alleviate the harmful effects of lead on the reproductive system [9,10] . Recently, multiple studies demonstrated that selenium is one of the most significant bio elements that may have antioxidant benefits against heavy metalinduced oxidative damage [11,12] . Selenium [Se] is integrated into selenoproteins in the form of selenocysteine to provide a variety of biological features.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]

Abdel Hady,

Abd-Allah,

Emam

et al. 2023

International Journal of Medical Arts

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Article informationBackground: Several industrial products [such as paints, cosmetics, and petrol] contained metals like lead [Pb], which are harmful to people. The reproductive organs are the primary organs affected by heavy metal toxicity through the production of oxidative stress. Selenium and curcumin could help to counteract this toxicity. Aim of the work:We investigated the possible role of Selenium or curcumin in improving the testicular toxicity caused by the intake of Lead orally in albino rats.Materials and Methods: 40 adult male albino rats were selected and unsystematically separated into 4 groups [10 rats/each] included: Group 1: control group; Group 2: Pb-exposed group; Group 3: Pb plus Selenium and Group 4: Pb plus Curcumin. Blood samples were collected for examination of serum biochemical parameters, serum Testosterone, LH, FSH levels, Total Anti-oxidant Capacity [TAC], testicular tissue oxidative stress parameters and testicular histology were evaluated.Results: Oral administration of Pb to rats for 4 weeks disturbs the testicular structure and function with a significant increase in the oxidative stress enzymes, deposition of collagen fibers and anticaspase-3 in the testis. While, administration of either Selenium or Curcumin with Pb-exposure induced significant improvement of all the testicular changes. Conclusion:Chronic lead exposure causes deteriorating changes in the testicular structures and functions which could be improved by oral intake of either Selenium or Curcumin by their antioxidant, antifibrotic, and antiapoptotic properties.

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“…14 Mitogen-activated protein kinases (MAPKs) are a group of evolutionarily conserved protein kinases in eukaryotes that can be divided into four subfamilies: ERK, p38, JNK, and ERK5. 15,16 MAPK signaling pathway can trigger multiple critical biological processes, like cell growth, differentiation, stress, and inflammatory responses. 17,18 Excessive reactive oxygen species (ROS) production in cells can cause oxidative stress.…”

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confidence: 99%

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

Wang,

Sun,

et al. 2023

Environmental Toxicology

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Imidacloprid (IMI) is a neonicotinoid insecticide with the highest global market share, and IMI exposure in the environment can negatively affect many nontarget organisms (a general term for organisms affected by drugs other than target organisms). Resveratrol (RSV), a non‐flavonoid polyphenolic organic compound derived from peanuts, grapes, and other plants, has anti‐inflammatory and antioxidant effects. It is currently unclear how RSV protects against cell damage caused by IMI. Therefore, we established an experimental model of chicken lymphocyte lines exposed to 110 μg/mL IMI and/or 0.5 μM RSV for 24 h. According to the experimental results, IMI markedly raised intracellular reactive oxygen species levels and diminished the activity of the cellular antioxidant enzymes (CAT, SOD, and GPx), leading to MDA accumulation and decreased T‐AOC. JNK, ERK, and P38, the essential components of the mitogen‐activated protein kinase (MAPK) signaling pathway, were also expressed more when IMI was present. Additionally, IMI resulted in upregulation of mitochondrial apoptosis (Caspase 3, Caspase 9, Bax, and Cyt‐c) and necroptosis (Caspase 8, RIPK1, RIPK3, and MLKL) related factors expression, downregulation of Bcl‐2 expression, induction of upregulation of cytokine IL‐6 and TNF‐α expression, and downregulation of IFN‐γ expression. The combined treatment of RSV and IMI significantly reduced cellular oxidative stress levels, inhibited the MAPK signaling pathway, and alleviated IMI‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction. To summarize, RSV antagonized IMI‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway.

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Protective mechanism of selenium on mercuric chloride-induced testis injury in chicken via p38 MAPK/ATF2/iNOS signaling pathway

Cited by 18 publications

References 41 publications

Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

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