Protective influence of antioxidant vitamins on hematological indices of rabbits fed crude-oil-contaminated diet

Ichipi-Ifukor

et al. 2021

eijs

The use of medicinal plants in the treatment of harmful impacts of xenobiotics in animals is attracting an increasing attention in recent times. The aim of the current study is to assess the preventive potential of Costus afer aqueous leaves extract (CAAE) in treating metabolic aberrations imposed by crude oil contaminated diet inWistar albino rats. Six groups of rats were treated as follows: A = Normal diet; B=Normal diet + 100 mg/kg body weight of CAAE; C =Normal diet + 200 mg/kg body weight of CAAE; D= Crude oil contaminated diet; E= crude oil contaminated diet + 100 mg/kg body weight of CAAE, F = crude oil contaminated diet + 200 mg/kg body weight of CAAE. After thirty days of exposure to the diet and administration of the corresponding plant extracts, the rats were sacrificed with chloroform and the required organs were excised. The hematological indices, as well as function indicators and levels of drug metabolizing enzymes in the liver and kidney, were investigated with standard protocols. The results indicated that the hematological parameters and kidney and liver function indices were altered in rats fed with crude oil contaminated diet. However, the values came close to those in control rats when Costus afer aqueous extracts were administered. Similarly, the activities of oxidase enzymes (aldehyde oxidase, monoamine oxidase, xanthine oxidase, and sulphite oxidase), following their inhibition by the ingestion of crude oil contaminated diet, equally restored close to control values upon treatment with Costus afer aqueous extract. This study, therefore, was able to establish an aqueous extract of Costus aferleave as an antidote for crude oil intoxication.

Section: Resultssupporting

confidence: 92%

Protective influence of Costus afer Aqueous Extract In Rats Fed With Crude Oil Contaminated Diet as Measured by Employing Biochemical Indices

Mordi

Ichipi-Ifukor

et al. 2021

eijs

“…Also, the protective properties of oil palm leaves has previously been documented (25). The increase in the oxidative stress status of the plasma during crude oil abuses and the resultant anemia have previously been reported by other studies (26,27). The same could be mentioned of induction of disease processes by crude oil (28).…”

Section: Discussionsupporting

confidence: 80%

Protective Role of Elaesis guineensis Leaves against Crude Oil Tainted Diet–induced Hematotoxicity in Wistar Rats

2019

IJT

Background: Crude oil is a very toxic chemical. Recently, the search for protective substances is attracting attention. This study aimed to investigate the hematoprotective potentials of oil palm leaves against the toxicity induced by crude oil. Methods: Male Wistar albino rats (n=36) were divided into six groups of rats (n=6). Group 1 (controls) were fed with normal rat food. Groups 2 and 3 were fed with diets combined with a predetermined quantity of Elaesis guineensis (E. guineensis) leaves. Group 4 were given crude oil contaminated diet. Groups 5 and 6 were fed with tainted diet, mixed with a predetermined quantity of powdered E. guineensis leaves. Results: Pre-treatment of the diet with oil palm leaves restored lipid peroxidation, the activities of various types of superoxide dismutases (SODs), and catalase compared to those obtained for the control group. Treatment of crude oil-tainted diet with oil palm leaves significantly increased hemoglobin concentration and red blood cell indices, and significantly decreased white blood cell count compared to those noted for the rats fed crude oil-tainted diet. Conclusions: This study found that the treatment of crude oil contaminated diet with oil palm leaves reduced the hemotoxicity as experimented in Wistar albino rats.

“…The use of antioxidant in ameliorating the deleterious effect of free radicals has been the subject of previous investigations [8] , [9] , [10] , [11] . Hence, use of spice with antioxidants property is necessary to suppress oxidative stress in a healthier way [12] .…”

Section: Introductionmentioning

confidence: 99%

Protective effect ofMonodora myristicaextracts on crude petroleum oil-contaminated catfish (Clarias gariepinus) diet in rats

Okpoghono

International Journal of Veterinary Science and Medicine

George

2018

Humans and animals are constantly exposed to crude petroleum contaminated diets in petroleum producing areas of the world. As a result, researches are on-going to find simple ameliorative agent against crude petroleum contaminated diet toxicity. The aim of this study was to evaluate the protective effect of Monodora myristica on some biochemical parameters of rats fed with crude petroleum oil contaminated catfish diet (CPO-CCD). Thirty male albino rats were separated into six groups of five rats as follows: group 1: control, group 2: rats were fed CPO-CCD only, group 3: CPO-CCD plus 1 ml/kg of 1 % tween 80, group 4: CPO-CCD plus M. myristica water extract (MWE), group 5: CPO-CCD plus M. myristica ethanol extract (MEE) and group 6: CPO-CCD plus M. myristica diethyl ether extract (MDEE). The feeding of the rats with CPO-CCD and administration of extracts orally lasted for 28 days. The results showed significant (P < 0.05) increase in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) in the serum and tissues (liver, kidney and brain) and decrease in total protein, albumin and globulin in the serum and liver of group 2 and 3 when compared with group 1. Significant (P < 0.05) decrease in AST, ALT, ALP activities and increase in total protein, albumin and globulin levels were observed after treatment with M. myristica extracts (group 4, 5, and 6) when compared with group 1. However, it could be concluded that MDEE revealed a strong effect when compared with the MEE and MWE.