Protective immunity of grass carp immunized with DNA vaccine encoding the vp7 gene of grass carp reovirus using carbon nanotubes as a carrier molecule

Zhu, Bin; Liu, Guanglu; Gong, Yu-Xin; Ling, Fei; Wang, Gao‐Xue

doi:10.1016/j.fsi.2014.11.026

Cited by 78 publications

(31 citation statements)

References 51 publications

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“…Recent years, DNA vaccines of grass carp hemorrhage have achieved gratifying progress. Studies have demonstrated the immunogenicity of GCRV structural proteins such as VP4 [ 206 ], VP6 [ 214 ], and VP7 [ 204 , 215 ]. DNA vaccine of GCRV VP6 gene has been provided with significantly protective effect against hemorrhagic disease [ 216 ].…”

Section: Prevention and Treatmentmentioning

confidence: 99%

Insights into the Antiviral Immunity against Grass Carp (Ctenopharyngodon idella) Reovirus (GCRV) in Grass Carp

Rao

2015

Journal of Immunology Research

182

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Global fish production from aquaculture has rapidly grown over the past decades, and grass carp shares the largest portion. However, hemorrhagic disease caused by grass carp reovirus (GCRV) results in tremendous loss of grass carp (Ctenopharyngodon idella) industry. During the past years, development of molecular biology and cellular biology technologies has promoted significant advances in the understanding of the pathogen and the immune system. Immunoprophylaxis based on stimulation of the immune system of fish has also got some achievements. In this review, authors summarize the recent progresses in basic researches on GCRV; viral nucleic acid sensors, high-mobility group box proteins (HMGBs); pattern recognition receptors (PRRs), Toll-like receptors (TLRs) and retinoic acid inducible gene I- (RIG-I-) like receptors (RLRs); antiviral immune responses induced by PRRs-mediated signaling cascades of type I interferon (IFN-I) and IFN-stimulated genes (ISGs) activation. The present review also notices the potential applications of molecule genetic markers. Additionally, authors discuss the current preventive and therapeutic strategies (vaccines, RNAi, and prevention medicine) and highlight the importance of innate immunity in long term control for grass carp hemorrhagic disease.

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Section: Prevention and Treatmentmentioning

confidence: 99%

Insights into the Antiviral Immunity against Grass Carp (Ctenopharyngodon idella) Reovirus (GCRV) in Grass Carp

Rao

2015

Journal of Immunology Research

182

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“…Nucleic acids are anionic in nature; therefore for strong vector/vaccine interactions to occur the liposomes must contain a component that is cationic to provide a charged bonding between the two constituent elements. Cationic liposomes have been shown to make effective vectors[82] with several lipids capable of fulfilling the role of cationic component. However an issue with cationic liposomes is that of toxicity.…”

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confidence: 99%

Designing liposomal adjuvants for the next generation of vaccines

Perrie

Crofts

Devitt

et al. 2016

Advanced Drug Delivery Reviews

108

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Liposomes not only offer the ability to enhance drug delivery, but can effectively act as vaccine delivery systems and adjuvants. Their flexibility in size, charge, bilayer rigidity and composition allow for targeted antigen delivery via a range of administration routes. In the development of liposomal adjuvants, the type of immune response promoted has been linked to their physico-chemical characteristics, with the size and charge of the liposomal particles impacting on liposome biodistribution, exposure in the lymph nodes and recruitment of the innate immune system. The addition of immunostimulatory agents can further potentiate their immunogenic properties. Here, we outline the attributes that should be considered in the design and manufacture of liposomal adjuvants for the delivery of sub-unit and nucleic acid based vaccines.

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“…The immune protection assay shows that IgM and other antiviral immune responses are significantly triggered and 82% protection ratio is achieved [107]. Other researches on GCRV gene engineering vaccines mainly concentrate on the cell proliferation enhancing activity and immunoprotection of GCRV VP6 and VP7 recombinant plasmid [194][195][196][197]. A GCRV VP6 DNA vaccine obtained by baculovirus expression system can achieve a protection ratio of 95% [198].…”

Section: Cyprinid Viral Disease Vaccinementioning

confidence: 99%

Cyprinid viral diseases and vaccine development

2018

Fish & Shellfish Immunology

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In the past decades, global freshwater fish production has been rapidly growing, while cyprinid takes the largest portion. Along with the rapid rise of novel forms of intensive aquaculture, increased global aquatic animal movement and various anthropogenic stress to aquatic ecosystems during the past century, freshwater fish farming industry encounter the emergence and breakout of many diseases, especially viral diseases. Because of the ability to safely and effectively prevent aquaculture diseases, vaccines have become the mainstream technology for prevention and control of aquatic diseases in the world. In this review, authors summarized six major cyprinid viral diseases, including koi herpesvirus disease (KHVD), spring viraemia of carp (SVC), grass carp hemorrhagic disease (GCHD), koi sleepy disease (KSD), carp pox disease (CPD) and herpesviral haematopoietic necrosis (HPHN). The present review described the characteristics of these diseases from epidemiology, pathology, etiology and diagnostics. Furthermore, the development of specific vaccines respective to these diseases is stated according to preparation methods and immunization approaches. It is hoped that the review could contribute to aquaculture in prevention and controlling of cyprinid viral diseases, and serve the healthy and sustainable development of aquaculture industry.

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Protective immunity of grass carp immunized with DNA vaccine encoding the vp7 gene of grass carp reovirus using carbon nanotubes as a carrier molecule

Cited by 78 publications

References 51 publications

Insights into the Antiviral Immunity against Grass Carp (Ctenopharyngodon idella) Reovirus (GCRV) in Grass Carp

Insights into the Antiviral Immunity against Grass Carp (Ctenopharyngodon idella) Reovirus (GCRV) in Grass Carp

Designing liposomal adjuvants for the next generation of vaccines

Cyprinid viral diseases and vaccine development

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