Cyprinid viral diseases and vaccine development

Su, Hang; Su, Jian

doi:10.1016/j.fsi.2018.09.003

Cited by 87 publications

(50 citation statements)

References 183 publications

(260 reference statements)

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“…According to the OIE-Wahis system, there were nine outbreaks from November 2018 to late April 2019 in Iraq [ 17 ]. Moreover, between 2018–2019, the OIE-Wahis interface [ 17 ] (accessed on October 28th, 2019) reveals that KHVD was reported in Africa, Europe, and North America, an occurrence which might be connected with the global fish trade [ 1 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Mass mortality associated with koi herpesvirus in common carp in Iraq

Ababneh

Hananeh

Al‐Zghoul

2020

Heliyon

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Koi herpesvirus disease is a serious disease affecting both wild and common carp species in different continents throughout the world. Based on pathological and molecular findings, we document the presence of koi herpesvirus disease in Iraq as a cause of mass mortality among the common carp of the Tigris river. On a macroscopic level, the fish exhibited variably sized skin ulcerations throughout the entire trunk. The gills showed variable degrees of discoloration with an increased amount of slimy mucus. Microscopically, degeneration and necrosis with infiltration of a heterogenous population of inflammatory cells characterized different organs, primarily the skin and gills, with occasional intranuclear inclusion bodies that are consistent with koi herpesvirus disease. A semi-nested PCR assay coupled with sequencing confirmed the pathological diagnosis. Genotyping and sequence analysis of the TK gene, ORF 136 and markers I and II identified the isolated CyHV-3 as variant A1 of the Asian genotype TUSMT1 (J strain) displaying the I ++ II + allele.

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Section: Discussionmentioning

confidence: 99%

Mass mortality associated with koi herpesvirus in common carp in Iraq

Ababneh

Hananeh

Al‐Zghoul

2020

Heliyon

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“…Under a changing environment, disease risks to both the marine environment and aquacultured species are also likely to change. Longer summers will provide a wider window for pathogen outbreaks (Gubbins et al 2013;Jensen & Kristoffersen 2015;Lyngstad et al 2018;Su & Su 2018). This could cause changes in the epidemiology of endemic and exotic diseases in Maine, resulting in a longer period when aquacultured organisms will be at risk of infection.…”

Section: Emerging and Established Diseases In Finfish Aquaculturementioning

confidence: 99%

Resilience of cold water aquaculture: a review of likely scenarios as climate changes in the Gulf of Maine

Bricknell

Birkel

Brawley

et al. 2020

Reviews in Aquaculture

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Climate change is one of the biggest challenges facing development and continuation of sustainable aquaculture in temperate regions. We primarily consider the ecological and physical resilience of aquaculture in the Gulf of Maine (GoM), where a thriving industry includes marine algae, extensive and intensive shellfish aquaculture, and a well-established Atlantic salmon industry, as well as the infrastructure required to support these economically important ventures. The historical record of sea surface temperature in the GoM, estimated from gridded, interpolated in situ measurements, shows considerable interannual and decade-scale variability superimposed on an overall warming trend. Climate model projections of sea surface temperature indicate that the surface waters in the GoM could warm 0.5-3.5°C beyond recent values by the year 2100. This suggests that, while variability will continue, anomalous warmth of marine heatwaves that have been observed in the past decade could become the norm in the GoM ca. 2050, but with the most significant impacts to existing aquaculture along the southernmost region of the coast. We consider adaptations leading to aquacultural resilience despite the effects of warming, larger numbers of harmful nonindigenous species (including pathogens and parasites), acidification, sea-level rise, and more frequent storms and storm surges. Some new species will be needed, but immediate attention to adapt existing species (e.g. preserve/define wild biodiversity, breed for temperature tolerance and incorporate greater husbandry) and aquaculture infrastructure can be successful. We predict that these measures and continued collaboration between industry, stakeholders, government and researchers will lead to sustaining a vibrant working waterfront in the GoM.

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“…Grass carp reovirus (GCRV), a dsRNA virus, causes severe hemorrhagic disease in juvenile grass carp (Ctenopharyngodon idella) and black carp (Mylopharyngodon piceus) (24)(25)(26). Our previous research demonstrated the important roles of grass carp TLR22 in response to GCRV infection.…”

Section: Introductionmentioning

confidence: 99%

Thoroughly Remold the Localization and Signaling Pathway of TLR22

Liao

Rao

et al. 2020

Front. Immunol.

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TLR22 exists in nearly all the poikilothermic vertebrates and plays a central role in the initiation of innate immunity and activation of adaptive immunity. TLR22 signaling pathway has been characterized in detail in fugu (Takifugu rubripes). Here, we thoroughly remold the localization and signaling pathways of TLR22. We characterized TLR22a and TLR22b in grass carp (Ctenopharyngodon idella), designated as CiTLR22a and CiTLR22b, and explored the ligand(s), adaptor(s), and signaling pathway(s). Results show that both CiTLR22a and CiTLR22b localize to lysosome, acidic compartment. Correspondingly, CiTLR22a and CiTLR22b directly bind and respond to dsRNA analog poly(I:C) at pH 5, but not at pH 7.4, the physiological pH. Moreover, CiTLR22a and CiTLR22b exhibit antagonistic function in signal transmission, wherein CiTLR22a facilitates the protein and phosphorylation levels of IRF7 and enhances the promoter activities of major IFNs and NF-κBs, while CiTLR22b downregulates IRF7 phosphorylation and IRF3 protein level and suppresses the IFN and NF-κB pathways. Further investigations revealed that CiTLR22a restrains grass carp reovirus (GCRV) replication and protects cells from GCRV infection, whereas CiTLR22b plays a negative role in response to GCRV infection. This is the first time to systematically clarify the signaling pathways of two isotype TLR22s; especially, subcellular localization and adaptor are different from previous TLR22 report, which results from technical limitations. The results will serve the antiviral immune mechanisms in poikilothermic vertebrates and evolutionary immunology.

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Cyprinid viral diseases and vaccine development

Cited by 87 publications

References 183 publications

Mass mortality associated with koi herpesvirus in common carp in Iraq

Mass mortality associated with koi herpesvirus in common carp in Iraq

Resilience of cold water aquaculture: a review of likely scenarios as climate changes in the Gulf of Maine

Thoroughly Remold the Localization and Signaling Pathway of TLR22

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