Protective immune response mediated by neutrophils in experimental visceral leishmaniasis is enhanced by IL-32γ

Gomes, Rodrigo Saar; Silva, Muriel Vilela Teodoro; Oliveira, Milton Adriano Pelli de; Joosten, Leo A. B.; Ribeiro‐Dias, Fátima

doi:10.1016/j.cellimm.2021.104449

Cited by 3 publications

(2 citation statements)

References 69 publications

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“…IL-32γ increased the number of neutrophils in mouse spleen and liver after L. infantum infection via IL-17-dependent cell recruitment. Recombinant IL-32γ increased ROS production in both mouse and human neutrophils ( 92 ). Together, data suggest a crucial role of the IL-32γ–Th17–neutrophil axis in the control of experimental VL.…”

Section: Il-32 In Different Leishmaniasesmentioning

confidence: 99%

A Critical Overview of Interleukin 32 in Leishmaniases

Ribeiro‐Dias

Oliveira

2022

Front. Immunol.

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Interleukin-32 (IL-32) has several immune regulatory properties, which have driven its investigation in the context of various diseases. IL-32 expression is reported to be induced in the lesions of patients with American tegumentary leishmaniasis (ATL) by the New World Leishmania spp. that are responsible for causing ATL and visceral leishmaniasis (VL). IL-32 expression may elevate the inflammatory process through the induction of pro-inflammatory cytokines and also via mechanisms directed to kill the parasites. The genetic variants of IL-32 might be associated with the resistance or susceptibility to ATL, while different isoforms of IL-32 could be associated with distinct T helper lymphocyte profiles. IL-32 also determines the transcriptional profile in the bone marrow progenitor cells to mediate the trained immunity induced by β-glucan and BCG, thereby contributing to the resistance against Leishmania. IL-32γ is essential for the vitamin D-dependent microbicidal pathway for parasite control. In this context, the present review report briefly discusses the data retrieved from the studies conducted on IL-32 in leishmaniasis in humans and mice to highlight the current challenges to understanding the role of IL-32 in leishmaniasis.

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Section: Il-32 In Different Leishmaniasesmentioning

confidence: 99%

A Critical Overview of Interleukin 32 in Leishmaniases

Ribeiro‐Dias

Oliveira

2022

Front. Immunol.

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“…Since leishmaniasis is caused by the bite of sandflies on host skin, neutrophils in the blood pool are the most abundant leukocytes, and they are also the first batch of cells recruited to the infected site ( 40 ). Neutrophils play an immunomodulatory role by releasing NETs.…”

Section: Phylum Sarcomastigophora Class Zoomastigophoreamentioning

confidence: 99%

The State of Art of Extracellular Traps in Protozoan Infections (Review)

2021

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Protozoan parasite infection causes severe diseases in humans and animals, leading to tremendous economic and medical pressure. Natural immunity is the first line of defence against parasitic infection. Currently, the role of natural host immunity in combatting parasitic infection is unclear, so further research on natural host immunity against parasites will provide a theoretical basis for the prevention and treatment of related parasitic diseases. Extracellular traps (ETs) are an important natural mechanism of immunity involving resistance to pathogens. When immune cells such as neutrophils and macrophages are stimulated by external pathogens, they release a fibrous network structure, consisting mainly of DNA and protein, that can capture and kill a variety of extracellular pathogenic microorganisms. In this review, we discuss the relevant recently reported data on ET formation induced by protozoan parasite infection, including the molecular mechanisms involved, and discuss the role of ETs in the occurrence and development of parasitic diseases.

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Using meta-analysis and machine learning to investigate the transcriptional response of immune cells to Leishmania infection

Rezaei,

Tahmasebi,

Pourabbas

2024

PLoS Negl Trop Dis

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Background Leishmaniasis is a parasitic disease caused by the Leishmania protozoan affecting millions of people worldwide, especially in tropical and subtropical regions. The immune response involves the activation of various cells to eliminate the infection. Understanding the complex interplay between Leishmania and the host immune system is crucial for developing effective treatments against this disease. Methods This study collected extensive transcriptomic data from macrophages, dendritic, and NK cells exposed to Leishmania spp. Our objective was to determine the Leishmania-responsive genes in immune system cells by applying meta-analysis and feature selection algorithms, followed by co-expression analysis. Results As a result of meta-analysis, we discovered 703 differentially expressed genes (DEGs), primarily associated with the immune system and cellular metabolic processes. In addition, we have substantiated the significance of transcription factor families, such as bZIP and C2H2 ZF, in response to Leishmania infection. Furthermore, the feature selection techniques revealed the potential of two genes, namely G0S2 and CXCL8, as biomarkers and therapeutic targets for Leishmania infection. Lastly, our co-expression analysis has unveiled seven hub genes, including PFKFB3, DIAPH1, BSG, BIRC3, GOT2, EIF3H, and ATF3, chiefly related to signaling pathways. Conclusions These findings provide valuable insights into the molecular mechanisms underlying the response of immune system cells to Leishmania infection and offer novel potential targets for the therapeutic goals.

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Protective immune response mediated by neutrophils in experimental visceral leishmaniasis is enhanced by IL-32γ

Cited by 3 publications

References 69 publications

A Critical Overview of Interleukin 32 in Leishmaniases

A Critical Overview of Interleukin 32 in Leishmaniases

The State of Art of Extracellular Traps in Protozoan Infections (Review)

Using meta-analysis and machine learning to investigate the transcriptional response of immune cells to Leishmania infection

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