Protective efficacy of doramectin and ivermectin against Cochliomyia hominivorax

Patient with Tracheostomy Parasitized in Hospital by Larvae of the Screwworm,Cochliomyia hominivorax

“…There has been an increasing number of publications reporting that a subcutaneous injection of doramectin (200 µg/kg) was up to 100% effective as a C. hominivorax prophylactic, preventing infestation of artificial wounds, umbilical or castration wounds of calves, and infestation of post-parturient cows for up to 12–14 days post-treatment (Moya-Borja et al 1997; Anziani et al 2000). Caproni et al (1998) reported a persistent efficacy of doramectin and ivermectin in the prevention of natural C. hominivorax infestations in cattle castrated 10 days after treatment.…”

Ivermectina e abamectina em diferentes doses e vias de aplicação contra larvas de Cochliomyia hominivorax em bolsas escrotais de bovinos recém-castrados, provenientes da região sudeste do Brasil

“…Utilizando a mesma metodologia descrita neste estudo, LOPES et al MOYA BORJA et al (1997), no Brasil, avaliaram a efi cácia da doramectina e da ivermectina (200mcg/kg, subcutânea) contra larvas de C. hominivorax em bovinos experimentalmente infestados. Esses autores relataram que a doramectina eliminou 100% das larvas a partir de 48 horas pós-tratamento, enquanto que 29% dos animais tratados com ivermectina apresentaram, até o 7 o DPT, larvas ativas nas lesões.…”

“…Nos dias atuais, a utilização das avermectinas injetáveis e pour-on de ação prolongada facilitam o manejo do produtor e evitam a necessidade de repetições de tratamentos (MOYA BORJA 2003;MARTINS et al, 2009). Estudos que avaliam a efi cácia desse tipo de produto são encontrados mais facilmente com a doramectina (OLIVEIRA et al, 1993;MUNIZ et al, 1995;SANAVRIA et al, 1996;MOYA BORJA et al, 1997;LOPES et al, 2009;MARTINS et al, 2009;SAKAMOTO et al, 2009). Por outro lado, em relação à ivermectina e a abamectina pour-on, apesar de serem utilizadas preventivamente a campo no controle desse tipo de miíases, poucos estudos sobre a efi cácia destes princípios ativos estão descritos na literatura (ANZIANI et al, 1993;ANZIANI et al, 1996;LOMBARDERO et al, 1997;ANZIANI et al, 2000;).…”

Efficacy of macrocyclic lactones for the control of larvae of the Old World Screw‐worm Fly (Chrysomya bezziana)

“…[10][11][12] Doramectin also exhibits broad-spectrum activity and, when used as an injectable preparation, has been shown to be superior to ivermectin for the control of NWS, Cochliomyia hominivorax. [13][14][15] In the current study, we compare the duration of protection afforded by a SR bolus of ivermectin with that afforded by pour-on formulations of eprinomectin, doramectin and moxidectin. Pour-on formulations are quick and easy to use and, if effective, they would probably be the delivery system best suited for an emergency control situation.…”