Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics

Tian, Guobin; Zhang, Suhua; Li, Yanbing; Bu, Zhigao; Liu, Peihong; Zhou, Jinlin; Liu, Chengjun; Shi, Jianzhong; Yu, Kangzhen; Chen, Hualan

doi:10.1016/j.virol.2005.07.011

Cited by 217 publications

(142 citation statements)

References 51 publications

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“…In one of these studies, vaccination of ducks with inactivated influenza vaccine induced lower antibody titers and required larger dosage in comparison with vaccination of chickens. A second boost, however, seemed to help the relatively high antibody titers to last, although the boost generated only slightly higher antibody titers (Tian et al, 2005). As our results and previous studies show, ducks may be more likely to be re-infected with H9N2 even at shorter intervals.…”

Section: Discussionsupporting

confidence: 58%

“…Evidence also suggested that lack of secondary immune responses appeared to be a general feature of duck antibody responses (Kida et al, 1980;Lundqvist et al, 2006). Several inactivated influenza vaccines are currently used for controlling avian influenza in the laboratory and field studies (Tian et al, 2005;Nomura et al, 2012;). In one of these studies, vaccination of ducks with inactivated influenza vaccine induced lower antibody titers and required larger dosage in comparison with vaccination of chickens.…”

Section: Discussionmentioning

confidence: 99%

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Different outcomes of infection of chickens and ducks with a duck-origin H9N2 influenza A virus

Wang¹,

Li²,

Diao³

et al. 2014

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Summary. -As the major aquatic and terrestrial hosts for avian influenza viruses (AIVs), ducks and chickens play a critical role in the evolution and spread of the H9N2 virus. However, the outcomes of infection of ducks and chickens with the H9N2 virus are not sufficiently documented. In this study, we compared the outcomes of infection of chickens and Peking ducks with a duck-origin H9N2 virus. The results showed that this virus caused more pronounced clinical signs and histological lesions in chickens. As for the virus shedding, chickens shed more virus in the trachea and less virus in the cloaca in levels of interferon (IFN) γ were found in the trachea of ducks compared with chickens, while comparison with ducks. As for cytokines, namely IFNs and interleukins (IL), higher higher levels of IFN-β, IFN-γ, IL-1β, and IL-6 were observed in the ileum of chickens compared with ducks. Eventually, serum hemagglutination-inhibition (HI) antibody titers were higher in chickens than in ducks. Taken together, ducks and chickens use different strategies in response to the H9N2 virus infection in tissues representing main replication sites of low-pathogenic AIVs. Given the different outcomes of the H9N2 virus infection in ducks and chickens, different measures should be taken in vaccination and treatment.Keywords: duck-origin influenza A virus; H9N2 subtype; chicken; duck * Corresponding author. E-mail: yxdiao@126.com; phone: +86 0538 8249851-8210.# These authors contributed equally to this work. Abbreviations: AIV(s) = avian influenza virus(es); CL = cloacal; HA = hemagglutinin; HI = hemagglutination-inhibition; HPAIVs = highly pathogenic avian influenza viruses; IFN = interferon; IL = interleukin; LPAIV(s) = low pathogenic avian influenza virus(es); NA = neuraminidase; OP = oropharyngeal; p.i. = post infection

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Different outcomes of infection of chickens and ducks with a duck-origin H9N2 influenza A virus

Wang¹,

Li²,

Diao³

et al. 2014

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“…Mass vaccination against HPAI in Egypt was adopted on the basis of the predicted efficacy of H5N1 vaccines in a number of avian species (36)(37)(38)(39)(40) and the recommendation of FAO/OIE to use vaccination as part of a control strategy for HPAI. Furthermore, field trials of oil emulsion-whole-virus H5 vaccines have shown promise in controlling H5N1 influenza outbreaks in Vietnam and the People's Republic of China (41)(42)(43).…”

Section: Vaccinementioning

confidence: 99%

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Kim

Kayali

Walker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here, we describe that the failure of commercially available H5 poultry vaccines in Egypt may be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others, must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.

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“…Moreover the vaccine demonstrated high immunogenicity in domestic ducks and geese that is very important for counter-epizootic actions. Morbidity and mortality of the vaccinated chickens, ducks and geese was not observed at their challenge with the highly pathogenic strain A/goose/Guangdong/1/96 (H5N1) in dose 7.5 log EID 50 , though insignificant virus shedding into environment was reported (Tian et al, 2005, Qiau et al, 2006.…”

Section: Discussionmentioning

confidence: 99%

Immunogenicity of the inactivated oil emulsion influenza A (H5N1) vaccine in chickens

Kydyrbayev¹,

Tabynov²,

Ryskeldynova³

et al. 2010

ABJNA

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The goal of the presented research was to evaluate immunogenicity of the inactivated emulsified avian influenza (AI) type A (H5N1) vaccine that was developed on the basis of epizootically important autogenic AI virus strain A/domestic goose/Pavlodar/1/05 (H5N1) isolated in the epizooty focus in Pavlodarskaya oblast, Republic of Kazakhstan, in 2005. The results of the performed study show high level of vaccine immunogenicity. The vaccine is able to form the immunity for 12 months in 2-months chickens immunized in dose of 0.5 ml. The antihemagglutinating antibodies were detected in 14 days and reached their peak of 1:277 on the 6 th week post vaccination. The vaccination effectiveness is 100% from the 28 th day till the 150 th day post vaccination, then slowly decreases down to the level of 80% till day 360 post immunization (period of observation) that is sufficient for ensuring the safety of the vaccinated birds. Moreover the vaccine has high level of protectiveness demonstrating 100% protection of vaccinated birds on the 28 th day post vaccination and preventing virus shedding from cloaks and tracheas of chickens challenged with a field strain. The results of the study allow concluding that the developed inactivated emulsified AI vaccine of subtype H5 on the basis of the A/domestic goose/Pavlodar/1/05 (H5N1) possesses high protective ability and long-term immunogenicity.

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Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics

Cited by 217 publications

References 51 publications

Different outcomes of infection of chickens and ducks with a duck-origin H9N2 influenza A virus

Different outcomes of infection of chickens and ducks with a duck-origin H9N2 influenza A virus

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Immunogenicity of the inactivated oil emulsion influenza A (H5N1) vaccine in chickens

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