Protective effects of vitamin E on central nervous system in streptozotocin-induced diabetic rats

Abstract

Objective: To evaluate the histopathological and antioxidant effects of vitamin E (VE) treatment on brain tissue in streptozotocin (STZ)-induced diabetic rats. Methods: Thirty two male Wistar albino rats were used. The study comprised four groups of 8 rats: Group A - untreated group, group B - diabetic group, group C - VE and group D - diabetic plus VE. In the diabetic groups, diabetes was induced by a single intraperitoneal injection of 65 mg/kg STZ. Vitamin E was given 50 mg/kg/day i.p. for three weeks. Concentrations of glucose, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were detected in the haemolysate. Results: Glucose concentrations were increased in the blood of the STZ-treated rats compared with those in the diabetic groups (group B and D). The MDA concentrations in the brain from diabetic rats increased, whereas the GPx, SOD, CAT concentrations decreased. Treatment with VE returned concentrations of MDA, GPx, SOD and CAT toward control values. The MDA concentration in the diabetic group (20.65±2.24 nmol/mg Hb) was decreased compared with the VE treated group (15.54±1.32 nmol/mg Hb). There were no pathological differences between untreated and VE treated rats’ brains. Neuronal ischemic damages were determined in STZ-induced diabetic rats. Ischemic neuronal alterations in group B (diabetic) had more damage than group D (diabetic + VE). Conclusion: The study revealed neuroprotective effects of VE on ischemic damage in diabetic central neuronal cells, caused by diabetic oxidative stress.

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

“…Secondly, GSE and vitamin E treatment decreased oxidative stress in the hippocampus and plasma of diabetic rats. Consistent to our results, grape seed proanthocyanidin extracts (Xu et al, 2008) and vitamin E (Hong et al, 2004;Tuzcu and Baydas 2006;Kabay et al, 2009) have been shown to ameliorate increased oxidative stress in the brains of diabetic rats. Also, Sato et al (2001) have stated that grape seed proanthocyanidin extracts have in vivo antioxidant activity and can be as important as vitamin E in preventing ischemia/reperfusion induced oxidative damage and apoptosis in cardiomyocytes by reducing the lipid oxidation and/or inhibit the production of free radicals.…”

Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats

“…These alterations in the untreated diabetic group had more damage than the ellagic acid-treated diabetic group. Also, in a previous study, it was reported that STZinduced diabetes caused neuronal necrosis areas, hemorrhagic focuses, damaged blood vessels and degenerative changes in cells in diabetic group [34].…”

Evaluation of Some Biochemical Parameters and Brain Oxidative Stress in Experimental Rats Exposed Chronically to Silver Nitrate and the Protective Role of Vitamin E and Selenium

“…This trace element is known to antagonize the toxicity of silver ions (14). Vitamin E is a lipid-soluble chain-breaking antioxidant which protects, especially, biological membranes from lipid peroxidation (15). Deficiency of dietary vitamin E and selenium has been showed to induce a number of lesions in rats depending upon the degree of depletion (16).…”