Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats

Uzar, Ertuğrul; Alp, Harun; Çevik, Mehmet Uğur; Fırat, Uğur; Evliyaoğlu, Osman; Tüfek, Adnan; Altun, Yaşar

doi:10.1007/s10072-011-0775-1

Cited by 114 publications

(67 citation statements)

References 31 publications

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“…With respect to numerous reports in antioxidant role of EA on neuodegeneration [47][48][49][50], we can confirm anti-oxidative profile of EA. The SOD enzyme produces substrate for GPx activity in the brain under stressful situations [51,52].…”

Section: Discussionsupporting

confidence: 79%

“…However, the long-time study in reperfusion phase to show more specific role and perceive mechanism of EA effect should be designed in future studies. Several line of evidences consistently supports the claim that ellagic acid improves antioxidant enzymes and subsequently these enzymes might defend neuronal cells against produced free radicals in brain injuries [47,48,49]. Herein, we detected the two antioxidant enzymes (SOD and GPx) in the present or absence of ellagic acid in ischemic rats' tissues.…”

Section: Discussionsupporting

confidence: 77%

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Preventive Effects of Ellagic Acid on Nucleus Tractus Solitarius Electrical Activity and Oxidative Stress Altered by Cerebral Global Ischemia/Reperfusion in Rat

Nejad

Sarkaki

Dianat

et al. 2018

Braz. arch. biol. technol.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 77%

Preventive Effects of Ellagic Acid on Nucleus Tractus Solitarius Electrical Activity and Oxidative Stress Altered by Cerebral Global Ischemia/Reperfusion in Rat

Nejad

Sarkaki

Dianat

et al. 2018

Braz. arch. biol. technol.

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“…The TOS measurements provide a sensitive index of lipid peroxidation and oxidative stress. 23 In the kidney tissues and serum, we found that both the 50-mg and 100-mg ASA doses caused a significant increase in the TOS levels, which may be due to overproduction or decreased excretion of oxidant substances. We also found that the TAC levels and PON-1 activities decreased in the ASAadministered rats when compared with the controls.…”

Section: Discussionmentioning

confidence: 68%

Caffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats

Bozkurt

Türkçü

et al. 2012

Renal Failure

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Aim: The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced renal damage in rats. Materials and methods: A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) þ CAPE (20 μg/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) þ CAPE (20 μg/ kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), and paraoxonase-1 (PON-1) activity of the blood samples and kidney tissues were determined. Histopathological examinations of the kidneys were performed using light microscopic methods. Results: The TOS level in the serum of rats and kidney tissues given ASA (groups 2 and 4) significantly increased, but the levels of TAC and PON-1 in these tissues significantly decreased in group 4 when compared with the control rats (p < 0.05). The levels of TAC and PON-1 in the kidney tissues increased and the levels of TOS decreased in the CAPE treatment groups (groups 3 and 5) when compared with the rats in the no CAPE treatment groups (groups 2 and 4). The PON-1, TAC, and TOS values reverted to normal levels in group 5 when compared to group 4 (p < 0.05). These results were supported by histopathological observation. Conclusion: Oxidative stress plays an important role in ASA-induced nephrotoxicity, and CAPE may protect against ASA-induced nephrotoxicity in rats.

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“…Moreover, this compound has neuroprotective in focal cerebral ischemia, traumatic brain injury and also in brain histopathologic damage induced by streptozotocin in rats (Uzar et al 2012;Rafieirad & Ghasemzadeh-Dehkordi 2014;Farbood et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

Mansouri

Farbood

Naghizadeh

et al. 2016

Pharmaceutical Biology

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(2016) Beneficial effects of ellagic acid against animal models of scopolamine-and diazepam-induced cognitive impairments, Pharmaceutical Biology, 54:10, 1947-1953, DOI: 10.3109/13880209.2015 PHARMACEUTICAL BIOLOGY, 2016 VOL. 54, NO. 10, 1947-1953 http://dx.doi.org/10.3109/13880209.2015 Context In a previous study, it has been shown that ellagic acid (EA), a polyphenolic compound found in pomegranate and different berries, prevents cognitive and hippocampal long-term potentiation (LTP) impairments induced by traumatic brain injury in rats through antioxidant and anti-inflammatory mechanisms.Objective The present study was conducted to assess the potential of EA as a memory enhancer. Materials and methodsThe elevated plus maze (EPM) and passive avoidance (PA) paradigm were used to evaluate learning and memory parameters. Three doses (10, 30 and 100 mg/kg, i.p.) of EA were administered to animals. Memory impairment was induced by scopolamine treatment (0.4 mg/kg, i.p.) and/or diazepam (1 mg/kg, i.p.). Acquisition trials were carried out 30 min after scopolamine treatment and retention trials were performed for 5 min 24 h after the acquisition trials.Results EA at doses 30 and 100 mg/kg significantly reversed the amnesia induced by scopolamine (0.4 mg/kg, i.p.) in the EPM and PA tests in mice. Also, EA at doses 30 and 100 mg/kg significantly antagonized the amnesia induced by diazepam (1 mg/kg, i.p.) in EPM test in rats. Moreover, chronic administration of EA at dose 30 mg/kg ameliorated the memory deficit induced by diazepam (1 mg/ kg, i.p.) in rats. Discussion and conclusion This study demonstrates that ellagic acid is effective in preventing scopolamine-and diazepam-induced cognitive impairments without altering the animals' locomotion. This suggests the potential of EA application as a useful memory restorative agent in the treatment of dementia seen in elderly persons.ARTICLE HISTORY

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Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats

Cited by 114 publications

References 31 publications

Preventive Effects of Ellagic Acid on Nucleus Tractus Solitarius Electrical Activity and Oxidative Stress Altered by Cerebral Global Ischemia/Reperfusion in Rat

Preventive Effects of Ellagic Acid on Nucleus Tractus Solitarius Electrical Activity and Oxidative Stress Altered by Cerebral Global Ischemia/Reperfusion in Rat

Caffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats

Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

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