Protective effects of thymoquinone and melatonin on intestinal ischemia–reperfusion injury

Taş, Ufuk; Ayan, Murat; Söğüt, Erkan; Kuloğlu, Tuncay; Uysal, Murat; Tanrıverdi, Halil İbrahim; Şenel, Ufuk; Ozyurt, Birsen; Sarsılmaz, Mustafa

doi:10.4103/1319-3767.166203

Cited by 32 publications

(22 citation statements)

References 33 publications

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“…Moreover, TQ has been shown to inhibit the accumulation of inflammatory cells in bronchial alveolar fluid (BALF) and lung tissue (12). In a study of Tas et al, TQ has been found to cause decreased levels of malondialdehyde (MDA) in ischemia-reperfusion injury while increasing the level of glutathione (GSH) (13). A recent study reveals that TQ reverses cytokine increases such as tumor necrosis factor (TNF)-α and interleukin (IL)s caused by I/R in both serum and intestinal tissue (13).…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects

Parlar

Arslan

2020

Turk J Surg

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Section: Introductionmentioning

confidence: 99%

Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects

Parlar

Arslan

2020

Turk J Surg

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“…Apoptotic (TUNEL-positive) cells were counted and statistically assessed. This analysis was made in at least eight areas of each liver section (two sections/ animal), and the sections were analyzed at 400× magnifi cation (24).…”

Section: Terminal Deoxynucleotidyl Transferase Dutp Nick-end Labelingmentioning

confidence: 99%

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

Bilğiç¹,

Korkmaz²,

Azırak³

et al. 2018

BLL

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OBJECTIVES: The aim of the study was to investigate the possible protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver with histologic and biochemical assessments. METHODS: Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into fi ve groups as: group 1: control; group 2: OLZ; group 3: OLZ+TQ-1; group 4: OLZ+TQ-2; and group 5: OLZ+TQ-3. RESULTS: The results showed that a 2-week administration of OLZ (4 mg/kg, once a day for the fi rst week, 8 mg/kg once a day for the second week, p.o.) and treatment with TQ (25, 50, 100 mg/kg, once daily, p.o.) signifi cantly reduced weight gain induced by OLZ. In addition, TQ increased the total antioxidant status (TAS), high-density lipoprotein cholesterol (HDL), insulin levels and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), low density lipoprotein cholesterol (LDL), glucose, triglycerides (TG) and total cholesterol (CH) levels signifi cantly (p < 0.05). CONCLUSION: This study revealed that treatment with TQ might protect liver tissue against the side-effects of OLZ. TQ could be an effective course of therapy to enhance therapeutic effi cacy (Tab. 4, Fig. 4, Ref. 47). Text in PDF www.elis.sk.

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“…At least 400 cells were counted on each field. Apoptotic index was calculated as a ratio of the TUNEL -positive cell number to the total cell number (normal + apoptotic cells) (18,19).…”

Section: Tas Tos and Osi Determination Tasmentioning

confidence: 99%

Olanzapine-induced renal damage and metabolic side effects: the protective effect of thymoquinone

Bilğiç¹,

Korkmaz²,

Azırak³

et al. 2017

J Turgut Ozal Med Cent

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Aim: The goal of the study is to examine the protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat kidneys. Material and Methods: Thirty five female Spraque-Dawley rats were divided into 5 groups (n=7): Control, OLZ, OLZ+TQ-1, OLZ+TQ-2, OLZ+TQ-3. All treatments were administered for two weeks by gavage. Two weeks administration of OLZ (4 mg/kg, once a day for the first week, 8 mg/kg once a day for the second week, p.o.) was given to all groups, except control. TQ was administered (25, 50, 100 mg/kg, once daily) by gastric tube. On treatment day 15, kidney tissues were removed for analysis. Results: TQ increased the total antioxidant status (TAS) and decreased creatinine (Cr), blood urea nitrogen (BUN), oxidative stress index (OSI) and total oxidant status (TOS) levels significantly (p<0.05). Conclusion: These results revealed that TQ improved the side-effects of OLZ, contributed to the oxygen radical scavenging activity, increased antioxidant activity and had ameliorative effects on recovery of increased serum biochemical and oxidative stress parameters. Thus, these results demonstrated that TQ had protective and antioxidant effects against adverse effects of OLZ in kidney of rats. TQ could be an effective course of therapy to enhance therapeutic efficacy.

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Protective effects of thymoquinone and melatonin on intestinal ischemia–reperfusion injury

Cited by 32 publications

References 33 publications

Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects

Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

Olanzapine-induced renal damage and metabolic side effects: the protective effect of thymoquinone

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