Protective effects of three propolis-abundant flavonoids against ethanol-induced injuries in HepG2 cells involving the inhibition of ERK1/2-AHR-CYP1A1 signaling pathways

Ye, Manhong; Xu, Mengting; Fan, Shuhang; Zhang, Mengjie; Zhou, Bin; Yang, Shengmei; Wei, Wanhong; Ji, Chao; Ji, Jian; Ji, Fubiao

doi:10.1016/j.jff.2020.104166

Cited by 7 publications

(4 citation statements)

References 65 publications

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“…It also increased the antioxidant capacity of cells by upregulating the superoxide dismutase level and antioxidant gene expressions, such as GSTA1, TXNRD1, NQO-1, HO-1, and Nrf2, while reducing the expression of inflammatory genes of TNF-α and IL-8 [131]. Propolis-derived flavonoids, pinocembrin, galangin, and chrysin, prevented HepG2 cell injury by inhibiting ERK1/2-AHR-CYP1A1 signaling pathways [132]. ERK signaling pathways have been shown to be significant in the formation of liver fibrosis [133].…”

Section: Non-alcoholic Fatty Liver Disease (Nafld)mentioning

confidence: 97%

“…High-NaCl diet-induced hypertension has also been shown to be ameliorated by propolis. Zhou et al (2020) demonstrated that water-soluble propolis extract reduced the severity of hypertension induced by a high-NaCl diet in rats [88]. They demonstrated that the protective effect of a water-soluble extract of propolis was through several modes of action, such as the upregulation of antioxidant enzyme catalase (CAT) activity and the reduction in the vascular ROS level.…”

Section: Hypertensionmentioning

confidence: 99%

“…[ [131][132][133][134][135][136][137][138][139][140][141][142] human clinical trials Reduction in hepatic steatosis severity and inflammatory markers.…”

Section: Hypertension In Vivomentioning

confidence: 99%

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Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

et al. 2021

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Propolis is a resinous product collected by bees from plants to protect and maintain the homeostasis of their hives. Propolis has been used therapeutically by humans for centuries. This review article attempts to analyze the potential use of propolis in metabolic syndrome (MetS) and its associated chronic diseases. MetS and its chronic diseases were shown to be involved in at least seven out of the top 10 causes of death in 2019. Patients with MetS are also at a heightened risk of severe morbidity and mortality in the present COVID-19 pandemic. Propolis with its antioxidant and anti-inflammatory properties is potentially useful in ameliorating the symptoms of MetS and its associated chronic diseases. The aim of this article is to provide a comprehensive review on propolis and its therapeutic benefit in MetS and its chronic diseases, with an emphasis on in vitro and in vivo studies, as well as human clinical trials. Moreover, the molecular and biochemical mechanisms of action of propolis are also discussed. Propolis inhibits the development and manifestation of MetS and its chronic diseases by inhibiting of the expression and interaction of advanced glycation end products (AGEs) and their receptors (RAGEs), inhibiting pro-inflammatory signaling cascades, and promoting the cellular antioxidant systems.

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Section: Non-alcoholic Fatty Liver Disease (Nafld)mentioning

confidence: 97%

Section: Hypertensionmentioning

confidence: 99%

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Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

et al. 2021

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“…It has a protective effect on HepG2 hepatic cells damaged by ethanol. Chrysin, along with other ingredients of propolis, suppresses specific signaling pathways, i.e., ERK1/2 phosphorylation, AHR nuclear translocation and CYP1A1 expression [73]. Administration of chrysin prevents oxidative damage in the liver and kidneys induced by long-term alcohol consumption.…”

Section: Hepatoprotective Effects Of Chrysinmentioning

confidence: 99%

Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent

2021

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Chrysin belongs to the group of natural polyphenols. It can be found, among others, in honey, propolis and fruits and has a wide range of biological activities, including the prevention of oxidative stress, inflammation, neurodegeneration and carcinogenesis. Being a part of the human diet, chrysin is considered to be a promising compound to be used in the prevention of many diseases, including cancers, diabetes and neurodegenerative diseases such as Alzheimer’s or Parkinson’s. Nevertheless, due to the low solubility of chrysin in water and under physiological conditions, its bioavailability is low. For this reason, attempts at its functionalization have been undertaken, aiming to increase its absorption and thus augment its in vivo therapeutic efficacy. The aim of this review is to summarize the most recent research on chrysin, including its sources, metabolism, pro-health effects and the effects of its functionalization on biological activity and pharmacological efficacy, evaluated both in vitro and in vivo.

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Pinocembrin: Insights into the Resources, Biosynthesis, Bioavailability, Safety, Biological Activities and Pharmacology

Wong,

Ahmat,

Abas

2023

Handbook of Dietary Flavonoids

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Protective effects of three propolis-abundant flavonoids against ethanol-induced injuries in HepG2 cells involving the inhibition of ERK1/2-AHR-CYP1A1 signaling pathways

Cited by 7 publications

References 65 publications

Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent

Pinocembrin: Insights into the Resources, Biosynthesis, Bioavailability, Safety, Biological Activities and Pharmacology

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