Protective effects of taxifolin on pazopanib-induced liver toxicity: an experimental rat model

Akagündüz, Baran; Özer, Muhammet; Özçıçek, Fatih; Kara, Ali Veysel; Laçin, Şahin; Özkaraca, Mustafa; Çoban, Abdülkadir; Mammadov, Renad; Süleyman, Halis

doi:10.1538/expanim.20-0103

Cited by 10 publications

(8 citation statements)

References 36 publications

(34 reference statements)

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“…No previous studies have investigated the antioxidant and anti-inflammatory effects of taxifolin on the bladder. It has been documented that taxifolin protects liver tissue from oxidative damage by inhibiting the increase in MDA and TOS and decreasing the tGSH levels and TAS values due to pazopanib, an anticancer drug [13]. Another study reported that taxifolin protected optic nerve tissue against oxidative and inflammatory damage of the platinum-derived anticancer drug [34].…”

Section: Discussionmentioning

confidence: 99%

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Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…To implement this experiment, the TCYC group (n = 6) was given 50 mg/kg of taxifolin orally by gavage. This dose of taxifolin has been used in animals before and has been found to be effective against oxidative liver damage [13]. Normal saline (0.9% NaCl) was used as the solvent for the CYC (n = 6) and HC (n = 6) groups.…”

Section: Experiments Proceduresmentioning

confidence: 99%

Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats

et al. 2022

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“…Within the scope of the experiment, the TACR (n = 12) rat group was given 50 mg kgG 1 of taxifolin by oral gavage into their stomach 16,17 . The same volume of distilled water was applied to the ACR (n = 12) and HG (n = 12) groups by gavage.…”

Section: Methodsmentioning

confidence: 99%

Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

Dinc¹,

Kiremitli²,

Kiremitli³

et al. 2023

International J. of Pharmacology

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Background and Objective: Acrylamide (AA) is a toxin that can cause reproductive organ toxicity and infertility through oxidative stress.This study aimed to investigate the effect of taxifolin, an antioxidant flavonoid, against acrylamide-induced infertility and intrauterine growth disorder in rats. Materials and Methods: Thirty-six rats were randomly divided into HG, ACR and TACR groups. The TACR group was given orally 50 mg kgG 1 of taxifolin. One hour later, 20 mg kgG 1 acrylamide was administered orally to the ACR and TACR groups. This procedure was repeated once a day for 30 days. Afterward, 6 rats in the groups were euthanized with 50 mg kgG 1 thiopental sodium. The removed ovaries were analyzed biochemically and histopathologically. Others were kept in the laboratory with male rats for 2 months for breeding. Rats that did not become pregnant and did not give birth during this period were considered infertile. Intrauterine growth retardation was assessed by the weight of the offspring. Results: Taxifolin decreased the levels of malondialdehyde (MDA), total oxidant system (TOS) and oxidative stress index (OSI) that increased with acrylamide in ovarian tissues while preventing the decrease in Total Glutathione (tGSH) and total antioxidant system (TAS) levels. In the histopathological examination, it was observed that the damage in the ACR group decreased with the application of taxifolin. In addition, it was determined that it significantly prevented infertility and the decrease the birth weight of the offspring. Conclusion: Taxifolin may be a potential therapeutic strategy to prevent acrylamide-induced ovarian damage, infertility and intrauterine growth retardation.

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“…Experiment procedure A total of 50 mg/kg taxifolin 14 was administered orally to the stomach of rats by gavage in the TMTX group (n=6). Normal saline (0.9% NaCl) was applied to rats in MTX (n=6) and healthy (n=6) groups as solvent by the same method.…”

Section: Experimental Groupsmentioning

confidence: 99%

Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation

et al. 2022

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Effect of taxifolin on methotrexateinduced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluationThe role of oxidative stress, as well as inflammation in the pathogenesis of methotrexate (MTX)-induced oral mucositis, is a known fact. The antiinflammatory, antitumor, antimicrobial, and antioxidant properties of taxifolin-the effect we tested against MTX-induced oral mucosal damage-are well known. Objective: Evaluating biochemically and histopathologically the effects of taxifolin on methotrexate-induced oral mucosal damage in rats.Methodology: In the taxifolin+MTX (TMTX) group, 50 mg/kg taxifolin was orally administered to rats by gavage. In the MTX and healthy (HG) groups, normal saline was applied to rats as solvent by the same method. One hour after administration of taxifolin and solvent, 5 mg/kg MTX was orally administered to rats in the MTX and TMTX groups. Taxifolin and methotrexate were administered once a day for 30 days. Macroscopic, biochemical, and histopathological evaluations were performed on the inner cheek and tongue tissues of rats. These parts were removed after rats were killed with a highdose anesthesia. Results: Taxifolin with MTX prevented the increase in oxidant and pro-inflammatory parameters, such as malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), on the inner cheek and tongue tissues of rats. Moreover, taxifolin antagonized the decrease in total glutathione (tGSH). Taxifolin decreased MTX-induced histopathological damage. Conclusion: These findings suggest that taxifolin may be useful to treat MTX-associated oral mucositis.

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Protective effects of taxifolin on pazopanib-induced liver toxicity: an experimental rat model

Cited by 10 publications

References 36 publications

Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats

Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats

Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation

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