Protective effects of Solanum cernuum extract against chromosomal and genomic damage induced by methyl methanesulfonate in Swiss mice

Damasceno, Jaqueline Lopes; Oliveira, Pollyanna Francielli de; Miranda, Mariza Abreu; Leandro, Luís Fernando; Acésio, Nathália Oliveira; Ozelin, Saulo Duarte; Bastos, Jairo Kenupp; Tavares, Denise Crispim

doi:10.1016/j.biopha.2016.08.027

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Intensive research over the last few decades has shown the beneficial protective effects of medicinal plant extracts on different cell cultures both under in vitro (Ljubuncic et al, 2006;Leskovac et al, 2007;Milošević-Djordjević et al, 2013) and in vivo (Damasceno et al, 2016;Rahmouni et al, 2017) conditions. In the present study, we investigated the polyphenolic contents and genotoxic and antimutagenic effects of methanolic extracts of T. polium and T. scordium on PBLs from healthy donors.…”

Section: Discussionmentioning

confidence: 99%

Polyphenolic contents of Teucrium polium L. and Teucrium scordium L. associated with their protective effects against MMC-induced chromosomal damage in cultured human peripheral blood lymphocytes

Milošević-Djordjević¹,

Jakovljević²,

Marković³

et al. 2018

Turk J Biol

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Teucrium species have been used in traditional medicine for treatment of different diseases. The aim of this study was to investigate polyphenolic contents by high-performance liquid chromatography (HPLC), and the genotoxic effect of methanolic extracts of Teucrium polium and Teucrium scordium using the cytokinesis-block micronucleus (CBMN) assay on human peripheral blood lymphocytes (PBLs) from healthy donors. The HPLC analysis showed that extracts consist of phenolic acid (gallic, vanillic, caffeic, chlorogenic, p-coumaric, sinapic) and flavonoids (catechin, rutin, myricetin, luteolin, quercetin and apigenin). Cultures were treated with extracts of both plants separately and in combinations with mitomycin C (MMC). In separate treatments, both herbal extracts significantly induced micronucleus (MN) frequency only at the highest concentrations. All concentrations of T. scordium, except the lowest, and all concentrations of T. polium extracts in combined treatment with MMC significantly reduced the frequency of MN. The extract of T. polium did not significantly affect the nuclear division index (NDI), whereas T. scordium in higher concentrations, separately and in combined treatment with MMC, significantly decreased the NDI value. Our results suggest that both herbal extracts in combination with MMC have antimutagenic (T. polium) and proapoptotic effects (T. scordium), which indicates their protective effects in PBLs.

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Section: Discussionmentioning

confidence: 99%

Polyphenolic contents of Teucrium polium L. and Teucrium scordium L. associated with their protective effects against MMC-induced chromosomal damage in cultured human peripheral blood lymphocytes

Milošević-Djordjević¹,

Jakovljević²,

Marković³

et al. 2018

Turk J Biol

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“…The mutagenic effects exerted by plants are not easily noticeable in humans, and adverse long-term outcomes such as cancer can manifest. Thereby, the scientific literature has highlighted the importance of screening medicinal plants for their mutagenic potency [26, 35–37]. In this sense, here we have examined the Copaifera spp.…”

Section: Discussionmentioning

confidence: 99%

“…According to the literature, the use of different organisms or diverse test systems can provide distinct results [16, 35]. This is because genotoxicity and mutagenicity test systems are divided into two groups.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test

Damasceno

Arnet

Fortunato

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Trees of the Copaifera genus are native to the tropical regions of Latin America and Western Africa. Copaifera sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in Copaifera and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Bearing in mind the fact that the Ames test is an excellent tool to assess the safety of extracts, oils, and phytochemicals isolated from medicinal plants, from it, we evaluate the mutagenic potential of four species, between oleoresins (C. oblongifolia; C. langsdorffii) and leaves extracts (C. lucens; C. multijuga), of the Copaifera genus and also of kaurenoic acid, which is one of its major compounds. The results showed that the Copaifera spp. and kaurenoic acid did not induce an increase in the number of revertant colonies, without mutagenic effect in experiments, in the all concentrations evaluated by Ames test. The results obtained in our study support the safe use of the Copaifera genus medicinal plants selected and of kaurenoic acid.

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Genotoxic Activity of Secondary Metabolites of Teucrium Species

Grujičić

Marinković

Milošević-Djordjević

2020

Teucrium Species: Biology and Applications

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Protective effects of Solanum cernuum extract against chromosomal and genomic damage induced by methyl methanesulfonate in Swiss mice

Cited by 6 publications

References 27 publications

Polyphenolic contents of Teucrium polium L. and Teucrium scordium L. associated with their protective effects against MMC-induced chromosomal damage in cultured human peripheral blood lymphocytes

Polyphenolic contents of Teucrium polium L. and Teucrium scordium L. associated with their protective effects against MMC-induced chromosomal damage in cultured human peripheral blood lymphocytes

Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test

Genotoxic Activity of Secondary Metabolites of Teucrium Species

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