Protective effects of silymarin in broiler feed contaminated by mycotoxins: growth performance, meat antioxidant status, and fatty acid profiles

Armanini, Eduardo H.; Boiago, Marcel Manente; Cécere, Bruno Giorgio de Oliveira; Oliveira, Paulo Vinícius de; Teixeira, Carlos J S; Strapazzon, João Vitor; Bottari, Nathieli B.; Silva, Aniélen D.; Fracasso, Mateus; Vendruscolo, Raquel Guidetti; Wagner, Roger; Glória, Eduardo Micotti da; Horn, Vitor Waldir; Mendes, Ricardo E.; Baldissera, Matheus D.; Vedovatto, Marcelo; Silva, Aleksandro S. Da

doi:10.1007/s11250-021-02873-2

Cited by 16 publications

(14 citation statements)

References 27 publications

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“…Silymarin as a complex of active ingredients derived from milk thistle was found as hepato- and nephroprotective against ochratoxin A intoxication in broiler chickens and laying hens [ 16 , 20 ]. The protective effects of a silymarin product was observed on the liver of broilers fed a diet contaminated with aflatoxin and fumonisin [ 21 ]. The hepatoprotective effect of ground milk thistle seed was demonstrated by measuring serum activities of aspartate-aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in broiler chickens fed aflatoxin B1-contaminated diet [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Milk Thistle (Silybum marianum) Supplementation in Ducks Fed Mycotoxin-Contaminated Diets

Bencze-Nagy

Strifler

Horváth

et al. 2023

Veterinary Sciences

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The medicinal plant milk thistle (Silybum marianum) has been widely used due to its hepatoprotective properties. The main objective of our study was to investigate the health protective effects of dietary milk thistle seed (MS), oil (MO), and seed cake (MSC) in ducks fed diets naturally contaminated with deoxynivalenol (DON; 3.43–3.72 mg/kg feed) and zearalenone (ZEN; 0.46–0.50 mg/kg feed). Female White Hungarian ducks were randomly allocated to four dietary treatments consisting of the control diet (C), the control diet supplemented with 0.5% MS, 0.5% MSC, or 0.1% MO. The feeding of experimental diets did not result in mortality cases, clinical signs of mycotoxicosis, or in differences of clinical chemistry values of blood serum. The positive effect of MO on vacuolar hepatocyte degeneration exceeded that of the MSC on d14 and both MS and MSC on d42. Each treatment was equally effective in the decrease of the severity of solitary cell death and infiltration of lympho- and histiocytes in the liver on d28 as well as in the prevention of lymphocyte depletion in the spleen and bursa of Fabricius on d14. In conclusion, the applied treatments have been proven effective in the prevention of histopathological changes caused by DON and ZEN.

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Section: Introductionmentioning

confidence: 99%

Effects of Dietary Milk Thistle (Silybum marianum) Supplementation in Ducks Fed Mycotoxin-Contaminated Diets

Bencze-Nagy

Strifler

Horváth

et al. 2023

Veterinary Sciences

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“…This product is recommended by the supplier to improve productive performance. Several in vivo studies that evaluate the efficacy of CA-PFA components individually show that, to detect a statistically significant improvement in productive performance, the required doses of each component are 200 mg/kg of feed or higher ( Rajput et al, 2013 ; Sakomura et al, 2013 ; Armanini et al, 2021 ; Yang et al, 2022 ; Shanmugam et al, 2022 ; Surai and Surai, 2023 ; Sureshbabu et al, 2023 ; Zaki et al, 2023 ). The CA-PFA recommended commercial dose is 250 to 500 mg/kg of feed, which results in a smaller dose of its individual components than the reported efficacious dosages.…”

Section: Discussionmentioning

confidence: 99%

“…Betaine doses frequently used in studies that report statistically significant improvement in productive performance are 500 mg/kg of feed or higher ( Sakomura et al, 2013 ; Yang et al, 2022 ; Zaki et al, 2023 ). Silymarin inclusion in poultry diets improves broiler performance, however, results at low doses (100–200 mg/kg feed) are inconsistent, with some studies showing performance improvement ( Armanini et al, 2021 ; Shanmugam et al, 2022 ; Surai and Surai, 2023 ) while other studies report statistically non-significant differences, especially if broilers are grown under normal physiological conditions ( Schiavone et al, 2007 ; Blevins et al, 2010 ; Sakamoto et al, 2018 ; Lukanov et al, 2019 ; Zaker-Esteghamati et al, 2020 ). All the doses that have been confirmed as effective for these additives are higher than commercially recommended doses because of profitability reasons.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of commercial doses of a feed additive and silymarin on broiler performance with and without CCl4-induced liver damage

Barreiro Carpio,

Valdes-Pena,

Molina

et al. 2024

Poultry Science

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“…One hundred and eight 5-day-old chickens were divided into nine groups of twelve birds each. Each bird was orally infected with 10,000 fresh sporulated E. tenella oocysts and treated with 75 ppm of dihydroartemisinin [ 30 ], 500 ppm of silymarin [ 31 ], 200 ppm of genistein [ 32 ], 1000 ppm of resveratrol [ 33 ], 1000 ppm of quercetin [ 34 ], and 500 ppm of nerolidol [ 35 ] in their feed or drinking water (nerolidol). The concentrations used for the tested compounds were selected with reference to previous reports on their use as feed additives or on their processes (maximal price of ~USD 500/ton).…”

Section: Methodsmentioning

confidence: 99%

Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens

Hou,

Han,

Lin

et al. 2024

Microorganisms

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Chicken coccidiosis costs the poultry industry over GBP 10 billion per year. The main method of preventing and controlling coccidiosis in chickens continues to be the use of drugs. Unfortunately, the prevalence of drug resistance in the field reduces or even eliminates the effectiveness of drugs, and drug residues in the food supply chain can also can be harmful to humans. Therefore, safe and effective anticoccidial drugs are urgently needed. Natural products have many advantages such as being safe, effective and inexpensive and are a sustainable way to control coccidiosis. In this study, the anticoccidial effects of six natural compounds were tested by Eimeria tenella infection. Oocyst production, cecum lesion, body weight gain, feed conversion ratio, and intestinal microbiota were measured. The results showed that nerolidol had a moderate effect on maintaining both body weight gain and feed conversion ratio. Silymarin and dihydroartemisinin showed significant anticoccidial effects by reducing total oocyst output. Dihydroartemisinin also significantly reduced the cecum lesion caused by Eimeria infection, but this compound may be toxic to the host at such informed doses because it decreases growth and survival rates. In addition, both silymarin and dihydroartemisinin partly restored the microbiota after challenge. This indicates that silymarin, dihydroartemisinin, and nerolidol are effective in the control of chicken coccidiosis. Our data provide basic knowledge about the anticoccidial effects of such natural compounds/derivates.

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Protective effects of silymarin in broiler feed contaminated by mycotoxins: growth performance, meat antioxidant status, and fatty acid profiles

Cited by 16 publications

References 27 publications

Effects of Dietary Milk Thistle (Silybum marianum) Supplementation in Ducks Fed Mycotoxin-Contaminated Diets

Effects of Dietary Milk Thistle (Silybum marianum) Supplementation in Ducks Fed Mycotoxin-Contaminated Diets

Evaluation of commercial doses of a feed additive and silymarin on broiler performance with and without CCl4-induced liver damage

Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens

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