Protective Effects of Rutin through Regulation of Vascular Endothelial Growth Factor in Allergic Rhinitis

Kim, Hee-Yun; Nam, Sun‐Young; Hong, Seon-Pyo; Kim, Myong Jo; Jeong, Hyun‐Ja; Kim, Hyung-Min

doi:10.2500/ajra.2015.29.4195

Cited by 33 publications

(27 citation statements)

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“…Furthermore, hypotension induced by histamine causes hypoxia in brain tissues [23], and hypoxic environments upregulate HIF-1α-responsive chemokines, such as VEGF, which is known to promote the recruitment and proliferation of endothelial progenitor cells, and, in addition, up-regulation of HIF-1 promotes new blood vessel development [24]. Increased vascular permeability is known to induce inflammatory responses via VEGF [25]. In our previous study, rutin exerted anti-allergic effects by suppressing VEGF expression [25]; in another study, hypoxia induced histamine synthesis and histidine decarboxylase expression via HIF-1 activation in mast cells [10].…”

Section: Discussionmentioning

confidence: 99%

“…Increased vascular permeability is known to induce inflammatory responses via VEGF [25]. In our previous study, rutin exerted anti-allergic effects by suppressing VEGF expression [25]; in another study, hypoxia induced histamine synthesis and histidine decarboxylase expression via HIF-1 activation in mast cells [10]. In the present study, Buk music was found to inhibit systemic anaphylaxis and histamine release induced by compound 48/80, and to reduce the increases in HIF-1α and VEGF levels induced by anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

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The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Kim

Nam

et al. 2015

Int Arch Allergy Immunol

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Background: Anaphylaxis is associated with systemic vasodilation that causes low blood pressure and induces hypoxic brain damage. The sound of a Buk (Korean traditional drum) is similar to the human heart beat and affects blood pressure, heart rate, and the nervous system by increasing physiological excitation and sympathetic nervous system activity. So, this study focused on the effect of Buk music as a means of treating anaphylaxis. Methods: Mice were given an intraperitoneal injection of compound 48/80 (6.5 mg/kg, a mast cell degranulator). After compound 48/80 injection, mice were exposed to Buk music and white noise for 5 min in a sound isolation booth. The mortality rate was checked over the next 40 min. Levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in the serum and brain tissues were analyzed by Western blotting, quantitative real-time PCR, and ELISA methods. Results: Exposure to Buk music significantly reduced compound 48/80-induced mortality and histamine release, as well as HIF-1α and VEGF levels compared with the compound 48/80 group or compound 48/80 and white noise group. Buk music also reduced levels of tumor necrosis factor-α, and significantly increased estrogen receptor-β mRNA levels. Conclusion: These results indicate that Buk music has potential for the treatment of anaphylaxis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Kim

Nam

et al. 2015

Int Arch Allergy Immunol

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“…It has been used by locals to treat coughs, colds, wounds, and burn (Sharma, Gohil, & Kaul, ). Our previous study reported that AH alleviated clinical symptoms of allergic rhinitis in an animal model (Kim et al, ). Moreover, AH has an antimicrobial activity (Kim et al, ).…”

Section: Introductionmentioning

confidence: 92%

Protective effect of linoleic acid against inflammatory reactions by mast cell via caspase‐1 cascade pathways

et al. 2019

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Blockade of caspase‐1 was reported to be a new target for allergic inflammation treatment. Here, we present the effect of linoleic acid (LA), a constituent of Allium hookeri (AH), to alleviate mast cell‐mediated allergic inflammation. Pretreatment of LA and AH significantly reduced caspase‐1 activation without displaying host cell cytotoxicity in activated human mast cells. IC50 value of LA on caspase‐1 activity is 0.014 μM. LA and AH pretreatment effectively regulated increased levels of interleukin (IL)‐1β, IL‐6, IL‐8, thymic stromal lymphopoietin, and tumor necrosis factor on activated human mast cells. Moreover, LA and AH were effective against activations of nuclear factor‐κB and mitogen‐activated protein kinases in human mast cells. In summary, LA and AH alleviate allergic inflammatory reactions via blocking caspase‐1 cascade signaling pathway. These results provide evidence for the anti‐allergic inflammatory properties of LA and AH and corroborate its potential use for the treatment and prevention of allergic diseases. Practical applications Allium hookeri (AH) is used as traditional food to treat various diseases and contains an essential fatty acid, linoleic acid (LA). LA and AH alleviate mast cell‐mediated allergic inflammatory reactions via inhibiting inflammatory mediators. These results provide evidence for the anti‐allergic inflammatory properties of LA and AH and corroborate its potential use for the treatment and prevention of allergic diseases.

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“…Kim et al 14 reports that Allium hookeri has anti-inflammatory effects in these experimental models.…”

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confidence: 99%

Advancing the Field of Rhinology and Allergy

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Am J Rhinol�Allergy

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The May/June issue of the American Journal of Rhinology & Allergy contains several articles that advance the field of rhinology and allergy. This editorial will provide a high level summary of the articles contained in this issue-be sure to examine the articles in more depth on the following pages.Several studies in this issue focus on the pathophysiology of airway inflammation. Wang et al 1 studied the regulation of aquaporin-5, a channel protein important for fluid secretion in allergic inflammation. They tested the 4 concentrations of histamine on the expression of aquaporin-5 in human nasal epithelial cells, findings a dose dependent decrease in expression. They further discovered that the downregulation of aquaporin by histamine occurs via inhibition of the cyclic adenosine monophosphate-responsive element binding protein. Choi et al 2 found that Asian sand dust, generated from the deserts in China, are capable of inducing MUCH8 and MUC5b expression via TLR-4 dependent signaling pathways. These findings were derived from experiments using human nasal epithelial cells. Asian sand dust may be an important environmental trigger for TLR-4 pathway expression and subsequent promotion of airway inflammation. Lam et al 3 used sinus mucosal samples to demonstrate increased IL-25 and IL-33 expression, but not TSLP expression, in patients with chronic rhinosinusitis, nasal polyps, and Ͼ10 eosinophils/high power field, in a comparison study with normal control tissue. Linke et al, 4 in another study using human samples, this time nasal polyps and inferior turbinate tissue, found that STAT5b, but not STAT5a, is activated compared to controls in patients with chronic rhinosinusitis and nasal polyps. Finally, Esmaeilzadeh et al 5 identified genetic variabilities of major histocompatibility complex class II for patients with aspirin exacerbated respiratory disease, suggesting a role for T cell activation in the pathophysiology of this disease process.One study focused on sinonasal tumor pathophysiology. Jung et al 6 studied expression of the Wnt signaling pathway to better understand the mechanism involved in the malignant transformation of sinonasal inverted papillomas. Their findings suggest several Wnt pathway signaling proteins, including ␤-catenin, cyclin D1, and Dvl-1, are associated with malignant transformation.Two studies analyzed imaging results as a means to better understand challenging diagnostic and management issues in rhinology. Craig and Goyal 7 analyzed images of patients who sustained sphenoid fractures and found that CSF leaks occurred in 9% and blunt carotid injury occurred in just 2% of sphenoid fractures. They also found a significant association between sphenoid roof fractures and CSF leak and that penetrating issues were strongly associated with CSF leak. Lin et al 8 describe the use of volumetric analysis for assessment of orbital volume in patients with chronic maxillary atelectasis, also called silent sinus syndrome. They concluded that expansion of maxillary sinus and decrease in orbit volume ca...

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Protective Effects of Rutin through Regulation of Vascular Endothelial Growth Factor in Allergic Rhinitis

Abstract: The present study showed that A. hookeri or RU had an anti-allergic inflammatory effects. Analysis of these results indicated that A. hookeri and RU might protect against AR.

Cited by 33 publications

References 39 publications

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Protective effect of linoleic acid against inflammatory reactions by mast cell via caspase‐1 cascade pathways

Advancing the Field of Rhinology and Allergy

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