Protective Effects of Peony Root Extract and Its Components on Neuron Damage in the Hippocampus Induced by the Cobalt Focus Epilepsy Model

Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury

“…Paeoniflorin, isolated from P. lactiflora, is one of the major constituents of the peony plant. Extracts of the peony plant and their constituents have been reported to have various biological and biomodulating activities, including anti-inflammatory (Liu et al, 2006a;Zheng et al, 2007), antimutagenic (Sakai et al, 1990), antioxidant (Okubo et al, 2000;Li et al, 2007), antiepileptic (Tsuda et al, 1997), antihyperglycemic (Hsu et al, 1997), and neuroprotective (Liu et al, 2006b activities. Also, paeoniflorin could protect the heart from myocardial ischemia/reperfusion oxidative injury in rats (Nizamutdinova et al, 2008).…”

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway

“…It has been used in the treatment of cerebral ischemia (Liu et al, 2006), epilepsy (Tsuda et al, 1997), and neurodegenerative disorders such as Alzheimer's disease (Zhong et al, 2009) and Parkinson's disease (Liu et al, 2007). While the mechanisms of the neuroprotective effects of PF are still unclear, accumulating evidence suggests that it is closely associated with the homeostasis of mitochondria, including the suppression of inflammatory reactions (Liu et al, 2006), maintenance of intracellular calcium concentration (Tsai et al, 2005) and its ability to scavenge for reactive oxygen species (ROS) (Li et al, 2007), which lead to a progressive accumulation of oxidized protein aggregates and of dysfunctional mitochondria.…”

Differential regulation by Seogak Jihwang-Tang on cytokines production in peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness

“…The active compounds in Paeoniae radix rubra include paeoniflorin, benzoylpaeoniflorin, albiflorin, lactiflorin, oxypaeoniflorin, paeonin, paeoniflorigenone, paeonoside, paeonolide, paeonol, galloylpaeoniflorin, and gallotannin (Yang et al, 2000). Some studies have suggested that Paeoniae radix rubra has neuroprotective effects on neuronal damage (Yang et al, 2000;Tsuda et al, 1997), and Paeoniae radix rubra is used in ischemia and stroke therapy (Zang and Zhang, 1994).…”