Differential regulation by Seogak Jihwang-Tang on cytokines production in peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness

Jeong, Hyun‐Ja; Chung, Hwan‐Suck; Kim, Yo-Han; Moon, Byung-Soon; Sung, Kang-Keyng; Bai, Sun Joon; Cho, Kwang Ho; Kim, Yun-Kyung; Hong, Seung‐Heon; Shin, Taekyun; Kim, Hyung-Min

doi:10.1016/j.jep.2004.05.014

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Recent studies have investigated the effect of Korean medicines on IL-4 and IL-10 production in humans from lipopolysaccharides (LPS) or phytohaemagglutininstimulated peripheral blood mononuclear cells (PBMCs) of CI patients. Seogak Jihwang-Tang and Jeodang-Tang inhibited IL-4 production, and increased IL-10 production [117,118]. An anti-inflammatory cytokine, IL-10, significantly inhibited the production of other proinflammatory mediators, such as reactive oxygen intermediates, reactive CMLS, Cell.…”

Section: Cytokine Levelsmentioning

confidence: 99%

Aspects of gene polymorphisms in cerebral infarction: inflammatory cytokines

Jeong

Park

et al. 2005

CMLS, Cell. Mol. Life Sci.

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During the last decade, a growing corpus of evidence has indicated an important role of inflammatory cytokines in the pathogenesis of cerebral lesion following stroke. Recent data suggest that genetics may in turn contribute to modulating the effects of inflammatory cytokines on cerebral infarction (CI). This paper reviews the physiologic characteristics of major inflammatory cytokines and recent research developments related to cell biology and pathobiology in CI. In particular, this review focuses on the genetic aspects of inflammatory cytokines and their implications in CI.

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Section: Cytokine Levelsmentioning

confidence: 99%

Aspects of gene polymorphisms in cerebral infarction: inflammatory cytokines

Jeong

Park

et al. 2005

CMLS, Cell. Mol. Life Sci.

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“…Bone marrow-derived mesenchymal stem cells (MSCs) have highly proliferative capacity and more potential to divide. MSCs can differentiate into neuron-like cells and nerve glial cells in vitro and in vivo (8,9). MSCs can survive and migrate in rat brain after ischemia/reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

et al. 2009

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“…It has an important role in regulating antibody production, inflammation and the development of effector T-cell responses (Jeong et al 2004). Production of interleukin-4 (IL-4) is directing the immune system toward Th2-dependent allergic reactivity (Maggi 1998;Mueller et al 2002;Nelms et al 1999).…”

Section: Introductionmentioning

confidence: 99%

IL-4 gene expression in adventitial layer (fibrous layer) of hepatic ovine and bovine hydatid cysts

et al. 2014

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Cystic Echinococcosis is a parasitic disease with cosmopolitan distribution caused by the tape worm Echinococcus granulosus. Fibrous layer is developed around the cyst as a host immune response reaction. The aim of this study was to evaluate the rate of IL-4 gene expression in fibrous layer of bovine and ovine hepatic hydatid cysts using quantitative technique of Real-Time PCR. In this descriptive study the samples of hydatid cyst fibrous layer were taken from 6 bovine and 6 ovine hepatic hydatid cysts. Samples of normal liver tissue close to the cyst were also taken as controls. Total RNA from each sample was extracted and then converted to cDNA. Afterward, the rate of IL-4 gene expression for each sample was evaluated using real-time PCR technique. Data were analyzed by REST software (version 2.0.13, 2009). In sheep the rate of IL-4 gene expression in the fibrous layer of hepatic hydatid cysts was 1.98 times more than the rate of IL4 gene expression in control samples, but the difference was not significant (P = 0.561). In cattle the rate of IL-4 gene expression in the fibrous layer of hepatic hydatid cysts was 9.84 times more than that of control samples which was statistically significant (P \ 0.001). With high rate of IL4 expression especially in fibrous layer of bovine hydatid cyst, it can be concluded that this interleukin may play an important role in host parasite relationship.

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Differential regulation by Seogak Jihwang-Tang on cytokines production in peripheral blood mononuclear cells from the cerebral infarction patients presenting with altered consciousness

Cited by 8 publications

References 39 publications

Aspects of gene polymorphisms in cerebral infarction: inflammatory cytokines

Aspects of gene polymorphisms in cerebral infarction: inflammatory cytokines

Expression of IL-10 and TNF-α in Rats with Cerebral Infarction after Transplantation with Mesenchymal Stem Cells

IL-4 gene expression in adventitial layer (fibrous layer) of hepatic ovine and bovine hydatid cysts

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