Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions

Mohamadin, Ahmed M.; Sheikh, Bassem Y.; El-Aal, Amany Ahmed Abd; Elberry, Ahmed A.; Al-Abbasi, Fahad A.

doi:10.1016/j.pestbp.2010.05.011

Cited by 44 publications

(30 citation statements)

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“…The active agent that was found in NSO was Thymoquinone has been to shown to mitigate the activities OPs and other compounds that maybe involved in the inducement of hepatotoxicity and toxicity of other systems (35,49,50), and similar toxic substances (51,52). The hepato-protective effects of NSO in this study can be greatly attributed to its Thymoquinone constituent (53)(54)(55), since it has been reported to exhibit cerebral, renal, liver, and cardiac protective effects against many xenobiotic (56). Though there is a rapid turnover of hepatic cells especially during hepatic injuries, these activities may be further elevated with the presence of NSO which could serve in the positive modulation of the hepatic cells and creation of an enable environment which is a key factor during regeneration.…”

Section: Discussionmentioning

confidence: 72%

Histopathological and Biochemical evaluations of the antidotal efficacy of <i>Nigella sativa</i> oil on organophosphate induced hepato-toxicity

Ajao¹,

Abdussalam²,

Imam³

et al. 2017

Research Journal of Health Sciences

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Objective: The study was designed to investigate the effects of continuous exposure of dichlorvos (DDVP) on hepatic function and hepatic histomorphology, with the possible antidotal efficacy of Nigella sativa oil (NSO).Methods: Twenty four Wistar rats were randomly divided into four groups, with each group comprising of six rats. The groups were labelled as Sunflower oil (SFO), DDVP, DDVP+NSO and NSO. After 14 days of treatments, blood samples were collected, centrifuged and levels of ALP (Alkaline phosphatase), ALT (Alanine aminotransferase), AST (Aspartate aminotransferase) and GGT (γ-glutamyl-transferase) concentrations were estimated in the serum. The livers were removed and prepared for histopathological examinations and evaluation. Results:The findings of the study shows significant increase in the serum concentration of ALT, ALP, AST and GGT with a marked distortion in the hepatic architecture in rats administered with DDVP. However, Nigella sativa oil (NSO) was observed to ameliorate the levels of impairment in the assessed hepatic function parameters and relatively restoration in the hepatic architecture in DDVP+NSO treated animals when compared to the control and group administered with DDVP only. Conclusion:The study concludes that impaired liver functions and histomorphological tissue distortions observed in the experimental rats following DDVP exposure were ameliorated following the administration of NSO.

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Section: Discussionmentioning

confidence: 72%

Histopathological and Biochemical evaluations of the antidotal efficacy of <i>Nigella sativa</i> oil on organophosphate induced hepato-toxicity

Ajao¹,

Abdussalam²,

Imam³

et al. 2017

Research Journal of Health Sciences

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“…There was the significant recovery of renal glutathione content and anti-oxidant enzymes 49 . NSO significantly reduced propoxur-induced oxidative stress in brain of rats via free radicals scavenging mechanism 50 . Pre-treatment of rats with NSO reduced the subsequent cyclosporine (CsA) injury in heart by improvement in antioxidant enzyme status.…”

Section: Anti-oxidant Anti-inflammatory and Immunomodulatory Effectsmentioning

confidence: 94%

“…LD 50 values, obtained by single doses, orally and intraperitoneally administered in mice, were 28.8 ml/kg body weight and 2.06 ml/kg body weight, respectively 28 .…”

Section: Fig 1: A) the Nigella Sativa Plant; B) The Flower; C) The Pmentioning

confidence: 95%

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2015

IJPSR

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“…Other medical effects like: Antiasthmatic (M.H. Boskabady, et al 2010), protective toxicity (Ahmed M. Mohamadin et al 2010), plasma antioxidant capacity (Maznah Ismail et al 2010, Mahmoud et al, 2015, antifungal (Eugene A. Rogozhin et al 2010), anti-nephrotoxicity (İhsan and Engin 2010), antiallergic (Soheila et al 2010, retards the progression of atherosclerosis (Mohammad and Hedi, 2010) and many other diseases (G. Lupidi, et al 2010, Osama andSoliman, 2010) were cited.…”

Section: Introductionmentioning

confidence: 99%

Light, Salinity and Temperature Effects on the Seed Germination of Nigella Sativa L.

Alshammari¹

2017

GJBAHS

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This work was carried out in the laboratory of Botany in the College of Sciences in the University of Hail, Saudi Arabia. It deals with the germination conditions of Nigella sativa, used for medicinal purposes for centuries, both as an herb and pressed into oil, in Asia, Middle East and Africa.The germination requirements Nigella sativa, were studied under control conditions in the laboratory. Treatments included four light levels (0 :24) ; (6: 18) ; (12 : 12) then 24 :0) hour ( light : dark) period, six salinity concentrations (0, 2, 4, 6, 8, and 10 gl/L NaCl), and four temperature regimes (15°, 17°, 20° and 25°), using a completely randomized block design.This work shows that germination of Nigella sativa was very sensible to temperature with an optimum of 23°C. Germination will stop below 15°C and after 25°C. For salinity the best seed germination of all experiments was obtained in a distilled water control. The progressive increase in salinity, until 8g/l, have no significant effect on germination. The inhibition of germination was significant only after 10g/l. The absence of light give the best rate of germination that would be lower if light period increase and it will be inhibited completely at 18h of light regime. In this work optimal conditions for germination of Nigella sativa were determined.

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Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions

Cited by 44 publications

References 44 publications

Histopathological and Biochemical evaluations of the antidotal efficacy of <i>Nigella sativa</i> oil on organophosphate induced hepato-toxicity

Histopathological and Biochemical evaluations of the antidotal efficacy of <i>Nigella sativa</i> oil on organophosphate induced hepato-toxicity

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Light, Salinity and Temperature Effects on the Seed Germination of Nigella Sativa L.

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