Protective effects of Nigella sativa on gamma radiation-induced jejunal mucosal damage in rats

Orhon, Zeynep Nur; Uzal, Cem; Kanter, Mehmet; Erboğa, Mustafa; Demiroğlu, Murat

doi:10.1016/j.prp.2016.02.017

Cited by 22 publications

(16 citation statements)

References 34 publications

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“…Moreover, it has been found that TQ can directly modulate the activation of several signal transduction pathways including PI3K-Akt-mTOR that are frequently upregulated in various cancers and confer resistance to radiotherapy (Baskar et al, 2014; Kundu et al, 2014b). Radio-protective effect of TQ or Nigella sativa seed extracts was also observed in some in vivo studies (Velho-Pereira et al, 2012; Orhon et al, 2016). Results from those studies showed that animal treated with macerated extracts of Nigella sativa L. seeds (contains TQ along with other components) experienced less damage in their liver, spleen, brain, and intestines upon exposure to radiation.…”

Section: Tq With a Dual Mode Of Action: Radioprotection And Radiosensmentioning

confidence: 53%

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

et al. 2017

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Thymoquinone (TQ), the main bioactive component of Nigella sativa, has been found to exhibit anticancer effects in numerous preclinical studies. Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Moreover, TQ can specifically sensitize tumor cells toward conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize therapy-associated toxic effects in normal cells. In this review, we summarized the adjuvant potential of TQ as observed in various in vitro and in vivo animal models and discussed the pharmacological properties of TQ to rationalize its supplementary role in potentiating the efficacy of standard therapeutic modalities namely surgery, radiotherapy, chemotherapy, and immunotherapy. Altogether, we suggest further comprehensive evaluation of TQ in preclinical and clinical levels to delineate its implied utility as a novel complementary adjuvant therapy for cancer treatment.

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Section: Tq With a Dual Mode Of Action: Radioprotection And Radiosensmentioning

confidence: 53%

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

et al. 2017

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“…2,4,5 A recent evidence suggests that seed oil is protective against γ-radiation-induced damage in jejunal mucosa. 19 Nigella EO at a dose range of 5-20g/kg (oral feed) in chickens improved FCR and plasma lipid profile and antibodymediated immunity in a 6 weeks treatment. 20 In addition, Nigella oil reduced thyroid stimulating hormone (TSH) and anti-thyroid peroxidase antibodies in patients with Hashimoto's thyroiditis.…”

Section: Nigella On Immune Systemmentioning

confidence: 92%

Nigellalogy: A Review on Nigella Sativa

Islam

Guha

Hosen

et al. 2017

MOJBB

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“…N. sativa has significant protective role on jejunal mucosal injury after treatment with gamma radiation in rats (Orhon et al, 2016).…”

Section: Medical Pharmacological and Nutritional Benefitsmentioning

confidence: 99%

Nigella sativa – a Plant with Personality in Biochemistry and Experimental Medicine Researches

Ahmadi¹,

Scurtu²,

Tulcan³

et al. 2016

BUASVMCN-VM

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Last decades often presented references to traditional medicine, or culinary use of natural resources for a better health status, prevention or treatment of different diseases. One of the natural plants came lately in the researches as a miracle salve: Nigella sativa. Also commonly known as black cumin, the most use of this plant are the seeds, such as, as powder, as oil extract, or as hydro or alcoholic extracts. Culinary usage of N. sativa is referring to the seeds used as spice. Medical usage of this plantis mostly used as oil or extracts administrated orally or intraperitoneal. The best demonstrated bioactive component is thymoquinone, an alkaloid, monotherpenoid compound, that seems to be the key of medical benefits of N. sativa. Experimental medicine proved that seeds of black cumin have health enhancement and pharmaceutical effects, being used in various disseases (cardiac, digestive and respiratory diseases; hepatic and renal tonic; inflammations; reproductive and neural disorders, analgesic; appetite stimulant; cancer prevention and treatment; spasmolytic and diabetes. Seeds (as powder, oil or hydro, alcoholic extracts) have been demonstrated that have antimicrobial, antiparasitic, antitumoral, antidiabetic, antioxidant, and anti-inflammatory action. N. sativa is easy to cultivate, storing, and offering diver potential of use as seed, seed oil, different type of seed extracts.

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Protective effects of Nigella sativa on gamma radiation-induced jejunal mucosal damage in rats

Cited by 22 publications

References 34 publications

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

Nigellalogy: A Review on Nigella Sativa

Nigella sativa – a Plant with Personality in Biochemistry and Experimental Medicine Researches

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