Protective effects of N-acetylcysteine against arsenic-induced oxidative stress and reprotoxicity in male mice

Reddy, P. Sreenivasula; Rani, G. Pushpa; Sainath, S.B.; Meena, Ramovatar; Supriya, Ch.

doi:10.1016/j.jtemb.2011.08.145

Cited by 108 publications

(77 citation statements)

References 41 publications

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“…These results regarding rat weight, weight gain and testis weight are compatible with the previous studies (Reddy et al, 2011;Ferreira et al, 2012). It was found in this study that quercetin did not lead to a significant change in terms of rat weight, weight gain and testis weight.…”

Section: Discussionsupporting

confidence: 93%

“…The previous studies have shown that arsenic influences male reproductive functions, testis weight and structure, seminiferous tubule diameter, testosterone levels, oxidantantioxidant balance and sperm quality and causes cellular toxicity (Jana et al, 2006;Sanghamitra et al, 2008;Fouad et al, 2011;Reddy et al, 2011;Ferreira et al, 2012). With this study, it has been confirmed that arsenic has a toxic effect and causes histopathological damage, oxidative stress, lipid peroxidation and apoptosis in testis.…”

Section: Discussionsupporting

confidence: 74%

“…b P > 0.05 compared to arsenic group. (Manna et al, 2008;Das et al, 2009;Fouad et al, 2011;Reddy et al, 2011;Uygur et al, 2013). The antioxidant effect of quercetin was shown by Uygur et al (2014), who demonstrated that it prevented the reduction in GSH-Px and SOD activities and the increase in MDA levels associated with the increase in oxidative stress in testicular tissue.…”

Section: Discussionmentioning

confidence: 98%

“…Testicular membranes are rich in polyenoic fatty acids, which are vulnerable against oxidative deterioration. Lipid peroxidation causes loss of function in membranes, death cell through necrosis and ultimately testicular dysfunction (Manna et al, 2008;Das et al, 2009;Fouad et al, 2011;Reddy et al, 2011). MDA is the end product of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of quercetin against arsenic-induced testicular damage in rats

et al. 2016

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This study investigated the effect of quercetin on changes in testes due to arsenic exposure. Twenty-seven male rats were divided into three groups: control (10 ml kg day saline), arsenic (10 mg kg day sodium arsenite) and arsenic + quercetin (arsenic + 50 mg kg day quercetin). The rats were sacrificed at the end of 15-day experiment. There was no difference between control group and arsenic group in body weight gain, testicular weight and serum total testosterone level. Quercetin treatment did not cause a significant difference in these parameters. In the arsenic group rats, we determined deterioration in the structure of seminiferous tubules, a decrease in the number of spermatogenic cells, an increase in the number of apoptotic cells, a decrease in the number of PCNA-positive cells, a decrease in SOD, CAT and GSH-Px activities, and an increase in the MDA level in testicular tissue. In all these changes, arsenic+quercetin group showed an improved compared to arsenic group. The amount of arsenic increased in the arsenic group was compared to the control group, and there was no difference between arsenic group and arsenic + quercetin group in the amount of arsenic. In conclusion, quercetin prevented arsenic-induced testicular damage with its anti-apoptotic and antioxidant effects.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Protective effects of quercetin against arsenic-induced testicular damage in rats

et al. 2016

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“…A number of in vivo and in vitro studies have been conducted determining the role of NAC in combating arsenic poisoning. Reddy et al [121] reported that the impairment of spermatogenesis in arsenic-exposed mice is mediated through oxidative stress as well as arsenic's direct effect on the germinal compartment. These authors also reported that co-administration of NAC reduces arsenic-induced oxidative stress by decreasing lipid peroxidation and activating antioxidant enzymes in the testes, thereby ameliorating arsenic-induced suppressed reproduction in male mice.…”

Section: N-acetylcysteinementioning

confidence: 99%