Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats

Bellassoued, Khaled; Hsouna, Anis Ben; Athmouni, Khaled; Pelt, Jos van; Ayadi, Fatma; Rebaï, Tarek; Elfeki, Abdelfattah

doi:10.1186/s12944-017-0645-9

Cited by 54 publications

(45 citation statements)

References 61 publications

(48 reference statements)

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“…The pretreatment with p EO Ca and subsequently given CCl 4 showed a more or less normal architecture. Large numbers of inflammatory cells such as lymphocytes associated to hepatic sinusoidal inflammation, hepatocyte necrosis and devastating liver architecture were reported in CCl 4 treated animals by Bellassoued et al According to the same authors, the pretreatment with Mentha peperita EO (15 mg/kg) could remarkably correct the histopathological hepatic lesions induced by administration of CCl 4 . At the highest oil dose (40 mg/kg), liver damages were significantly corrected which depicts marked focal regenerative changes (actively dividing cells with a prominent nucleolus).…”

Section: Discussionmentioning

confidence: 90%

Potential anti‐inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride‐mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats

Hsouna

Dhifi

Saad

et al. 2018

Environmental Toxicology

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The present study aimed (1) to investigate the chemical composition as well as the antiinflammatory properties and in vitro antioxidant activity of Citrus aurantium peel essential oil (pEOCa) and (2) to evaluate its potential effect in vivo. The main results showed that the major components of pEOCa are Limonene and Linalool. Additionally, DPPH scavenging ability and β-carotene bleaching inhibition tests confirmed the antioxidant capacity of pEOCa. Our oil reduced the production of NO by LPS-stimulated RAW264,7 macrophages in a concentrationdependent. This inhibition occurred at a transcriptional level. pEOCa in CCl 4 treated rats alleviated hepatotoxicity as monitored by the improvement of hepatic oxidative stress biomarkers levels plasma biochemical parameters, and DNA molecule aspect. Furthermore, the mRNA gene expression of Cu-Zn SOD, CAT, and GPx increased under CCl 4 + pEOCa exposure to reach the same value to the control. Similarly, antioxidant activities of these three enzymes changed in accordance with the mRNA levels. These results were confirmed by the histological results. It seems obvious that the treatment with pEOCa prevented liver damage induced by CCl 4 , thus preventing the harmful effects of free radicals. K E Y W O R D Santioxidant activity, beneficial effect,

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Section: Discussionmentioning

confidence: 90%

Potential anti‐inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride‐mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats

Hsouna

Dhifi

Saad

et al. 2018

Environmental Toxicology

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“…Results obtained shows highly significant decrease (P < 0.001) in antioxidant markers, GSH, CAT, SOD, and GPx; however, a highly significant increase (P < 0.001) was noticed in the levels of XOD and LPO in the CCl 4 -treated group when compared with the control rats. Depletion of endogenous enzymatic and nonenzymatic antioxidants in CCl 4 intoxicated group could be attributed to CCl 4 generated cellular ROS production and the subsequent depletion of the antioxidant cellular system (Li et al 2005;Gowri et al 2008;Muhammad et al 2009;Boshy et al 2017 andBellassoued et al 2018). On the other hand, treatment with EERO alone at 100 mg/kg and 250 mg/kg does not show any significant change in the level of these biomarkers as compared with the control group.…”

Section: Discussionmentioning

confidence: 98%

Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

et al. 2019

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Background: There is a growing demand for remedies from natural sources to substitute synthetic therapeutic drugs and minimize their side effects and toxicity. The present study aims to evaluate the defensive ability of an ethanolic extract of Rosmarinus officinalis L. in carbon tetrachloride (CCl 4)-induced nephrotoxicity in male albino rats. Materials and methods: Thirty-six rats were divided into 6 groups (n = 6). Group I (control) received distilled water for 30 days orally. Nephrotoxicity was induced by CCl 4 (11% v/v with olive oil, i.p) 2 ml/kg body weight (b.wt.) in group II once a week for 30 days. Groups III and IV received the only herb in two doses 100 and 250 mg/kg of b.wt. respectively. Groups V and VI received an ethanolic extract of Rosmarinus officinalis (EERO, 100 and 250 mg/kg of b. wt.) along with 2 ml/kg b.wt. CCl 4 weekly for 30 days. Results: CCl 4 treatment induced highly significant (P < 0.001) elevation in kidney biomarkers, i.e., blood urea nitrogen and creatinine, kidney biochemicals, i.e., LPO and XOD, and decrease the levels of superoxide dismutase, catalase, glutathione peroxidase, and glutathione in tissue. However, EERO significantly (P < 0.001) restored the altered levels of these biomarkers in a dose-dependent manner. Furthermore, EERO also prevents histological alteration caused due to the toxicity of CCl 4. Conclusion: Our findings strongly support that ethanolic extract of Rosmarinus officinalis acts as a potent scavenger of free radicals to prevent the toxic effect of CCl 4 and hence validate its ethnomedicinal use.

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“…Bellassoued et al () investigated the effects of M . × piperita leaf essential oil has been demonstrated in CCl 4 induced model.…”

Section: Pharmacological Activities Of M × Piperitamentioning

confidence: 99%

Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.)—A review

Mahendran

Rahman

2020

Phytotherapy Research

150

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Peppermint (Mentha × piperita L) is a perennial, glabrous and strongly scented herb belongs to the family Lamiaceae. It is cultivated in a temperate region of Europe, Asia, United States, India and Mediterranean countries due to their commercial value and distinct aroma. In addition to traditional food flavouring uses, M. × piperita is well recognized for their traditional use to treat fever, cold, digestive, anti‐viral, anti‐fungal and oral mucosa and throat inflammation. The scientific studies provide awareness on the use of M. × piperita for biological effects such as anti‐oxidant, anti‐microbial, anti‐viral, anti‐inflammatory, biopesticidal, larvicidal, anticancer, radioprotective effect, genotoxicity and anti‐diabetic activity have been ascribed. A wide spectrum of bioactive phytochemicals such as flavonoids, phenolics lignans and stilbenes and essential oils are expected to be responsible for the aroma effects. In this sense, this present review provides an extensive overview of the traditional medicinal, phytochemical and multiple biological activities of this “Peppermint.”

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Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats

Cited by 54 publications

References 61 publications

Potential anti‐inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride‐mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats

Potential anti‐inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride‐mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats

Defensive role of Rosmarinus officinalis in carbon tetrachloride-induced nephrotoxicity and oxidative stress in rats

Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.)—A review

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