Protective effects of memantine and epicatechin on catechol-induced toxicity on Müller cells in vitro

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products

“…Lipoic acid protects against the effects of Bisphenol A or Bi-n-butyl phthalate on testicular mitochondrial toxicity [210,211]. In various other models it also protects against the toxic effects of acetaminophen [212], acrolein [213], cyclosporine [214], indomethacin [215], paraquat [216] and rotenone [217] as well as cypermethrin [218], dimethoate, glyphosate and zineb [219],chrysene [220] lindane [221] and Tetrachlorodibenzodioxin [222]. Lipoic acid and other antioxidants have also been used in the clinical management and prevention of heavy metal intoxication [223].…”

ZnO nanoparticles induced cytotoxicity on human pulmonary adenocarcinoma cell line LTEP-a-2

“…The LDH activity in LTEP-a-2 cells was measured according to the method of Saffar Mansoor [Mansoor et al, 2013]. Cells were inoculated into 96-well plates in accordance with the procedure mentioned above.…”

In Vitro Evidence for Mycophenolic Acid Dose-Related Cytotoxicity in Human Retinal Cells

“…MPA (25 mg/mL and 50 mg/ mL)-treated cultures did not show significant decrease in caspase-3/7 activity. 24 hours of exposure to the drug by causing decrease in cell viability and upregulation of caspase-3/7 activity (suggestive of apoptosis), whereas lower doses did not cause in vitro cell toxicity.…”

“…23 Muller cells have previously been shown to be damaged by lipophilic drugs in in vitro assays. 24,25 The cell viability dye exclusion assay has been used by our group to test in vitro cell survival after exposure to different substances, such as steroids, trypan blue, and indocyanine green. [26][27][28][29] However, the exposure of retinal cells to sublethal dose of any drug may trigger the apoptotic cascade without causing a decrease in cell viability after 24 hours.…”