Protective Effects of Levosimendan and Iloprost on Lung Injury Induced by Limb Ischemia-Reperfusion: A Rabbit Model

Inhibition of reactive oxygen species downregulates the MAPK pathway in rat spinal cord after limb ischemia reperfusion injury

“…Injury to organs such as the lung, kidney, and liver after hind limb IR can be caused by systemic cellular mediators rather than local failure of individual organs [10][11][12][13]. Han et al reported that the generation of free radicals following hind limb IR led to chronic pain via central sensitization of the spinal cord [14].…”

Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats

“…It has vasodilator, positive inotropic and anti-ischemic effects (6-9). Levosimendan not only protects cardiac tissue against IRI but also reduces the risk of the spinal cord, lung and renal tissue damage (10)(11)(12).…”

An Evaluation of The Systemic Antiinflammatory Effects of Levosimendan in Experimental Blunt Thoracic Trauma Model

“…in ventilator-related pulmonary damage and sepsis experimental models are reduced, and cellular level inflammation and proinflammatory responses are suppressed. [11][12][13][14] This study outlines the therapeutic properties and effects of levosimendan on the potential systemic antiinflammatory response in an experimental rat model of unilateral PC.…”