Protective effects of Lactobacillus reuteri SJ-47 strain exopolysaccharides on human skin fibroblasts damaged by UVA radiation

Zhao, Jingsha; Fu, Hao; Li, Meng; Wang, Dongdong; Zhao, Dan; Zhang, Jiachan; Wang, Changtao

doi:10.1186/s40643-022-00617-0

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…The extracellular metabolites produced by Saccharomyces boulardii have rich biological activities, showing high antioxidant, antibacterial, and anti-inflammatory properties (Fu et al 2023a ). Lactobacillus reuteri SJ-47 strain exopolysaccharides can improve antioxidant capacity and delay skin photoaging caused by UVA radiation (Zhao et al 2022 ). It can be seen from the above that probiotics have a wide range of applications.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Wang,

Zhang,

Wang

et al. 2023

Bioresour. Bioprocess.

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Background Aureobasidium pullulans (A. pullulans) has a wide range of applications. Ultraviolet (UV) rays from the sun can cause skin photoaging. In order to explore the protective effect and application potential of A. pullulans lysate on UV-damaged human skin fibroblasts (HSF) and HaCaT Cells, this study investigates the anti-aging and anti-inflammatory effects of A. pullulans lysate as well as the mechanism of anti-oxidative stress at the cellular and molecular levels through cytotoxicity experiments, enzyme-linked immunosorbent assays (ELISA), and real-time quantitative PCR (RT-qPCR). Results The experimental results have shown that the A. pullulans lysate can effectively reduce the loss of extracellular matrix components (EMC), such as collagen and hyaluronic acid (HA). It is also capable of scavenging excess reactive oxygen species (ROS) from the body, thereby increasing the activity of catalase, decreasing the overexpression of intracellular matrix metalloproteinases (MMPs), enhancing the gene expression of metalloproteinase inhibitors (TIMPs), and decreasing the level of inflammatory factors, reducing UV-induced apoptosis of HaCaT cells. Meanwhile, oxidative stress homeostasis is also regulated through the Nrf2/Keap1 and MAPK signaling pathways. Conclusions This study shows that the A. pullulans lysate has the potential to resist photoaging. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%