“…These results suggest the possible toxicity of lethal doses of N. sativa. Whereas these were different with previous study which report the protective effect of N. sativa against renal injury in rat kidneys [32]. In the present study, group 2 with only MSG treatmentis significantly decrease interleukin-10 compared withcontrol group, this result was agreement with Hassan et al IL-10 is an anti-inflammatory cytokine producedin large amounts from activated B-lymphocytes and play a regulatory role in suppressing harmful immune responses.…”
Overconsumption of food additives monosodium glutamate (MSG), a flavour enhancer was unhealthy. Herbal medicine Nigella sativa (NS) has antioxidant properties able to cure the toxic induced by MSG. This study aimed to evaluate the risks of excessive use of MSG and to study the role of NS to inhibit inflammation and renal damage. Treated rats (twenty four male wistar rats) were divided into six group and analyzed by measuring the cells in blood, interleukin-10, interferon-γ serum levels by ELISA method and remove kidneys for histological examination. Histological of kidney for all groups except control, were showed different abnormalities include congestion of some blood vessels, hemorrhage between tubules, widening in the renal tubules, revealed severe dilatation of Bowman's capsule, shrinkage of glomeruli, and huge vacuole area, were observed compared with control. Interleukin-10 was reduced in Groups 2,3,4 and 5, whereas increase in group 6 compared with control. Interferon-γ was increased in groups 2,3,4 and reduced in groups 5,6 compared with control. Eosinophil was increased in groups 2,5 and reduced in groups 3,4 and 6. Basophil was reduced in groups 2, 3 and increased in groups 5 and 6 compared with control. This present study showed that administration of MSG to rats induced many changes effffects on inflammatory cells, cytokines and histological of kidneys. NS has benefit in blood parameters, whereas harmful on kidney at these doses.
“…These results suggest the possible toxicity of lethal doses of N. sativa. Whereas these were different with previous study which report the protective effect of N. sativa against renal injury in rat kidneys [32]. In the present study, group 2 with only MSG treatmentis significantly decrease interleukin-10 compared withcontrol group, this result was agreement with Hassan et al IL-10 is an anti-inflammatory cytokine producedin large amounts from activated B-lymphocytes and play a regulatory role in suppressing harmful immune responses.…”
Overconsumption of food additives monosodium glutamate (MSG), a flavour enhancer was unhealthy. Herbal medicine Nigella sativa (NS) has antioxidant properties able to cure the toxic induced by MSG. This study aimed to evaluate the risks of excessive use of MSG and to study the role of NS to inhibit inflammation and renal damage. Treated rats (twenty four male wistar rats) were divided into six group and analyzed by measuring the cells in blood, interleukin-10, interferon-γ serum levels by ELISA method and remove kidneys for histological examination. Histological of kidney for all groups except control, were showed different abnormalities include congestion of some blood vessels, hemorrhage between tubules, widening in the renal tubules, revealed severe dilatation of Bowman's capsule, shrinkage of glomeruli, and huge vacuole area, were observed compared with control. Interleukin-10 was reduced in Groups 2,3,4 and 5, whereas increase in group 6 compared with control. Interferon-γ was increased in groups 2,3,4 and reduced in groups 5,6 compared with control. Eosinophil was increased in groups 2,5 and reduced in groups 3,4 and 6. Basophil was reduced in groups 2, 3 and increased in groups 5 and 6 compared with control. This present study showed that administration of MSG to rats induced many changes effffects on inflammatory cells, cytokines and histological of kidneys. NS has benefit in blood parameters, whereas harmful on kidney at these doses.
“…Its scavenging actions have been demonstrated in a number of tissues [40,41,42,58], although the protection for ovaries has not been evaluated in detail. In the present study, a reduction in SOD and GSH levels and an increase in MDA levels occurred after a period of ischemia followed by reperfusion.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, clinical and animal studies have shown that an extract of NS has many therapeutic effects, including antiproliferative, anti-inflammatory, antitumor, anticancer, multiple myeloma, antibacterial, estrogenic, and antioxidant activity [32,33,34,35,36,37,38,39]. Experimental studies have also revealed that thymoquinone has protective effects against I/R injury in the intestine [40], liver [41], kidney [42], and testicular torsion [43]. It has also been reported that the crude NS seeds did not produce any adverse side effects at the doses tested [44].…”
<b><i>Background:</i></b> To evaluate biochemically and histopathologically the effects of <i>Nigella sativa</i> (NS) in experimental ischemia and ischemia/reperfusion (I/R) injury in rat ovaries. <b><i>Methods:</i></b> Thirty-six female rats were divided into 6 groups: group I = sham operation; group II = 500 mg/kg NS + sham operation; group III = bilateral ovarian ischemia; group IV = 500 mg/kg NS + ischemia; group V = 3-hour period of ischemia + 3-hour reperfusion, and group VI: 3-hour period of ischemia + 500 mg/kg NS 2.5 h after the induction of ischemia + 3-hour reperfusion. At the end of ischemia, the bilateral vascular clips were removed, and 3-hour reperfusion was continued. IL-1β, IL-6, and TNF-α cytokine levels in serum, and superoxide dismutase (SOD), myeloperoxidase (MPO), glutathione (GSH), and malondialdehyde (MDA) levels were determined. <b><i>Results:</i></b> I/R increased the MDA level and MPO activity while significantly decreasing the SOD activity and GSH level when compared to the sham. The 500-mg/kg dose of NS before I/R reversed the trend in MDA levels, MPO activity, SOD activity, and GSH levels. Ischemia and I/R increased the serum levels of IL-1β, IL-6, and TNF-α, while the administration of NS decreased the serum levels of these cytokines. <b><i>Conclusions:</i></b> The administration of NS is effective in reversing tissue damage induced by ischemia and/or I/R in ovaries.
“…N. sativa treatment significantly reduced OSI and TOS levels and increased TAC levels in both kidney tissue and blood. Results revealed the protective effect of N. sativa against renal I/R injury in rat kidneys [91] . GM induced nephrotoxicity has been shown to involve the generation of oxygen free radicals.…”
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