Protective effects of<i>Mentha spicata</i>against nicotine-induced toxicity in liver and erythrocytes of Wistar rats

Saad, Ahmed S.; Rjeibi, Ilhem; Alimi, Hichem; Ncib, Sana; Bouhamda, Talel; Zouari, Nacim

doi:10.1139/apnm-2017-0144

Cited by 18 publications

(9 citation statements)

References 41 publications

(20 reference statements)

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“…It induces oxidative stress both in vitro and in vivo (Budzynska, Boguszewska‐Czubara, Kruk‐Slomka, Kurzepa, & Biala, ). Moreover, nicotine exposure increases free radicals production (mediators of inflammation) and cooperative lipid peroxidation levels in various tissues (Ben Saad et al, ). Oxidative stress induced by nicotine may play an important role in the pathogenesis of different diseases (Alexandrov et al, ; Hamza & El‐Shenawy, ).…”

Section: Introductionmentioning

confidence: 99%

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The effect of green tea consumption on the expression of antioxidant‐ and inflammation‐related genes induced by nicotine

et al. 2019

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The aim of this study is to investigate the protective effect of green tea (GT) against the toxicity of nicotine. BALB/c mice were divided into four groups. Group I received food and water intake ad libidium, Group II received GT solution at a dose of 1 ml/kg body weight orally twice a day via gastric gavage, Group III was injected intraperitoneally with nicotine (2.5 mg/kg) once per day for 4 weeks, and Group IV received both nicotine and GT; GT was introduced using gastric gavage 1 hr before and 1 hr after the nicotine injection. The administration of nicotine altered the cellular antioxidant defense system by inducing inflammation and damage in the tissues of liver, lungs, and kidneys. In addition, nicotine treatment significantly enhanced the expression antioxidant‐ and inflammation‐related genes. There were significant improvements when the nicotine‐exposed mice treated with GT. Practical applications In this study, it is revealed that the administration of nicotine altered the cellular antioxidant defense system by inducing inflammation manifested by the infiltration of inflammatory cells and damage seen in liver, lungs, and kidneys. GT contributed to the reduction of toxicity of nicotine, probably mediated by free radicals, through downregulation of nicotine‐induced upregulated antioxidant‐ and inflammation‐related genes. Never the less, further in depth investigation on characterization of the active constituents of GT responsible for their effect seen here and the mechanism that contributes to the effects seen in this reports is highly demanded. Furthermore, GT extract could be considered as a dietary supplement for the reduction of nicotine toxicity among cigarette smoker.

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Section: Introductionmentioning

confidence: 99%

“…levels in various tissues (Ben Saad et al, 2018). Oxidative stress induced by nicotine may play an important role in the pathogenesis of different diseases (Alexandrov et al, 2016;Hamza & El-Shenawy, 2017).…”

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confidence: 99%

The effect of green tea consumption on the expression of antioxidant‐ and inflammation‐related genes induced by nicotine

et al. 2019

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“…In spite of the wide advocacy for their use as pesticides, little is currently known about the potentially toxic effects that may arise from their use. The treatment of albino rats with an aqueous solution of nicotine, a compound derived from Nicotiana tabacum, caused oxidative stress and damage to the liver (BenSaad et al, 2018;Chowanski et al, 2016). Recently, we showed that oil extracts of clove, S. aromaticum also caused oxidative stress and liver damage in male Wistar rats (Adeyemi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Camellia sinensis on Syzygium aromaticum- or chlorpyrifos-induced reproductive toxicity in male Wistar rats

Akinwande

Adeyemi

Olawuyi

et al. 2019

JoBAZ

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Background: The potential toxicity of clove, Syzygium aromaticum, notwithstanding its beneficial health effect to human health remains a critical issue. Purpose: This study was designed to assess the effects of oil extracts of clove (S. aromaticum) on reproductive parameters in Wistar rats. The ameliorative effect due to co-administration with green tea, Camellia sinensis, was also determined. Methods: Adult rats were exposed via oral gavage to mineral oil (negative control), 5% green tea (GT), 12.5 mg/kg/day chlorpyrifos (CHL, positive control), 360 mg/kg/day clove oil (CO), green tea + chlorpyrifos (GT+CHL), or green tea + clove oil (GT+CO) for 3 weeks, after which the animals were sacrificed and the following sperm parameters: total sperm count, sperm motile count, sperm progressive assessment, and sperm morphology were determined. The serum levels of reproductive hormones, testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH), were determined. The histological sections of the testes were also performed. Results: The results revealed that S. aromaticum treatment resulted in significant damage to the sperm morphology especially at the neck and tail regions with only a marginal change to the total sperm count, sperm motile count, and sperm progressive assessment. The levels of testosterone, FSH, and LH decreased significantly in rats treated with S. aromaticum. Histopathological analyses revealed significant disruption of normal testes structure in rats that were treated with either clove oil or chlorpyrifos. Conclusion: Overall, the results of this study show that the co-administration with C. sinensis has the potential to ameliorate the clove-induced reproductive toxicity in rats.

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“…Some plants are abundant in polyphenols that could act as bioactive components to prevent carcinomas and oxidative stress [48,49]. Mentha spicata supplementation protected the liver of Wistar rats against nicotine-induced oxidative damage [50]. Therefore, the ROS-scavenging efficacy of SGV was elevated by kale supplementation and contributed to prevention of cytotoxicity by nicotine.…”

Section: Resultsmentioning

confidence: 99%

Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification

Choi

Lee

et al. 2019

Nutrients

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Graviola leaves contain much vitamin U (vit U), but their sensory quality is not good enough for them to be developed as food ingredients. Addition of excipient natural ingredients formulated alongside vit U as active ingredients could enhance not only its sensory quality but also its bioavailability. The objectives of this study were to measure the bioaccessibility and intestinal cellular uptake of bioactive components, including rutin, kaempferol-rutinoside, and vit U, from steamed extract of graviola leaves (SGV) and SGV enriched with kale extract (SGK), and to examine how much they can detoxify nicotine in HepG2 cells. The bioaccessibility of vit U from SGV and SGK was 82.40% and 68.03%, respectively. The cellular uptake of vit U in SGK by Caco-2 cells was higher than that in SGV. Cotinine content converted from nicotine in HepG2 cells for 120 min was 0.22 and 0.25 μg/mg protein in 50 μg/mL of SGV and SGK, respectively, which were 2.86 and 3.57 times higher than the no-treatment control. SGK treatment of HepG2 cells upregulated CYP2A6 three times as much as did that of SGV. Our results suggest that graviola leaf extract enriched with excipient ingredients such as kale could improve vit U absorption and provide a natural therapy for detoxifying nicotine.

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Protective effects ofMentha spicataagainst nicotine-induced toxicity in liver and erythrocytes of Wistar rats

Cited by 18 publications

References 41 publications

The effect of green tea consumption on the expression of antioxidant‐ and inflammation‐related genes induced by nicotine

The effect of green tea consumption on the expression of antioxidant‐ and inflammation‐related genes induced by nicotine

Protective effects of Camellia sinensis on Syzygium aromaticum- or chlorpyrifos-induced reproductive toxicity in male Wistar rats

Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification

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