Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population

Wasityastuti, Widya; Yano, Yoshihiko; Ratnasari, Neneng; Triyono, Teguh; Triwikatmani, Catharina; Indrarti, Fahmi; Heriyanto, Didik Setyo; Yamani, Laura Navika; Liang, Yujiao; Utsumi, Takako; Hayashi, Yoshitake

doi:10.1016/j.meegid.2016.03.034

Cited by 18 publications

(22 citation statements)

References 48 publications

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“…Recent studies demonstrated that HLA-DPA1 SNPs rs3077 and rs9277378, which are located in the 3’UTR and 2Kb upstream intronic site, respectively, are associated with spontaneously resolved HBV infection [26, 27] and chronicity of HBV [28, 29]. In this study, no significant association between HLA-DPA1 alleles and HBeAg seroconversion was found.…”

Section: Discussioncontrasting

confidence: 60%

Effect of HLA-DPA1 Alleles on Chronic Hepatitis B Prognosis and Treatment Response

Katrinli

Enç

Özdil

et al. 2016

North Clin Istanbul

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OBJECTIVE:Chronic hepatitis B (CHB) is a major health problem. The outcome of hepatitis B virus (HBV) infection is associated with variations in HLA-DPA1 alleles. The aim of this study was to investigate possible associations of HLA-DPA1 alleles with treatment response and with hepatitis B virus e antigen (HBeAg) seroconversion.METHODS:Eight different HLA-DPA1 alleles from 246 CHB patients were genotyped by polymerase chain reaction with sequence-specific primers at high resolution to investigate the association of HLA-DPA1 alleles with treatment response, development of cirrhosis, HBeAg seroconversion, and disease reoccurrence upon HBeAg loss.RESULTS:There was no significant association between HLA-DPA1 alleles and treatment response, development of cirrhosis, or HBeAg seroconversion. However, HLA-DPA1*04:01 allele was significantly more frequently found in patients who redeveloped disease upon HBeAg seroconversion (100% vs 36.8%: p=0.037; Fisher’s exact test).CONCLUSION:HLA-DPA1*04:01 allele may be a risk factor for reoccurrence of CHB after HBeAg seroconversion.

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Section: Discussioncontrasting

confidence: 60%

Effect of HLA-DPA1 Alleles on Chronic Hepatitis B Prognosis and Treatment Response

Katrinli

Enç

Özdil

et al. 2016

North Clin Istanbul

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“…The prevalence of HBV carriers is high (5%-7.99%) in China, 3 infection with HBV. Thereafter, many studies [6][7][8][9][10][11][12][13][14][15][16]21 have focused successfully evaluated the associations among HLA-DP, HBV infection, and infection outcomes, and a meta-analysis was conducted, 22 demonstrating that the HLA-DPA1 rs3077-T allele protected against HBV infection (OR of 0.59 for both rs3077CT and rs3077TT genotypes). However, whether HLA-DP expression is associated with HBV infection had not been previously verified in the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…A genome‐wide association study (GWAS) in Japan and Thailand by Kamatani and colleges found a significant association between chronic hepatitis B with HLA‐DPA1 and HLA‐DPB1 and 11 associated single nucleotide polymorphisms (SNPs), particularly rs3077C/T in HLA‐DPA1 and rs9277535A/G in HLA‐DPB1. Subsequently, they revealed the risk haplotypes HLA‐DPA1*0202‐DPB1*0501 and HLA‐DPA1*0202‐DPB1*0301 and protective haplotypes HLA‐DPA1*0103‐DPB1*0402 and HLA‐DPA1*0103‐DPB1*0401; many studies have verified these results in different ethnic genetic populations, demonstrating that HLA‐DPA1, HLA‐DPB1 and associated SNPs are related to susceptibility to HBV infection and have an important role in spontaneous clearance of HBV …”

Section: Introductionmentioning

confidence: 91%

Relationship between HLA‐DPA1 mRNA expression and susceptibility to hepatitis B

Liu

Yang

et al. 2018

Journal of Viral Hepatitis

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Chronic hepatitis B virus (HBV) infection is influenced by both viral and host factors. In genome‐wide association studies, the human leucocyte antigen HLA‐DPA1 and related polymorphism rs3077 were found to be associated with susceptibility to and spontaneous clearance of HBV infection. Here, we evaluated the association between HLA‐DPA1 mRNA expression and the risk of HBV infection. HLA‐DPA1 and rs3077 polymorphisms were investigated in 169 patients with chronic HBV and 217 healthy controls (HCs) from Sichuan Han blood donors using sequence‐based typing and meta‐analysis for HLA‐DPA1 alleles. HLA‐DPA1 mRNA levels were measured by real‐time polymerase chain reaction. The results showed that HLA‐DPA1 and rs3077 were associated with HBV infection in the Sichuan population. Rs3077T and DPA1*01:03 played protective roles in HBV infection, and rs3077C and DPA1*02:02 increased susceptibility to HBV infection. We found that the HLA‐DPA1 mRNA expression was decreased in the CHB group; in particular, the 3077CT, 3077TT, DPA1*01:03 and DPA1*02:01 alleles showed a significant decrease. Our results demonstrated, for the first time, that expression of HLA‐DPA1 alleles and rs3077 affected the risk of HBV infection. Genotypes with lower HLA‐DPA1 expression had a greater susceptibility to HBV infection. Thus, further independent studies are needed to strengthen the associations of these polymorphisms with susceptibility to and clearance of HBV infection in Chinese populations.

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“…A Chinese study by Zhu et al [40] the strongest relation to HBV infection from the HLA-DP locus: rs3077 on HLA DPA1 and rs9277535 on HLA DPB 1 in Japanese and Thai populations [50,51]. Subsequently, plenty of studies further demonstrated their roles [27,[52][53][54]. rs3077 and rs9277535 are significantly related to HBV persistent infection and both A alleles of these two SNPs are protection alleles in Chinese Han [55], Japanese and Korean [56], and European [57] populations, while in Chinese Zhuang subjects, only HLA-DP rs9277535A is associated with decreased risk [55].…”

Section: Hla Class II Allele Polymorphism and Hbv Infection Outcomesmentioning

confidence: 99%

HLA Class II Allele Polymorphisms and the Clinical Outcomes of HBV Infection

Zhang¹

2019

Human Leukocyte Antigen (HLA)

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In 2016, the global health sector strategy (GHSS) on viral hepatitis called for elimination of hepatitis B as a major public health threat by 2030 (i.e., 90% reduction in incidence and 65% in mortality). But persistence or clearance of hepatitis B virus (HBV) infection mainly depends upon host immune responses. The human leukocyte antigen (HLA) system is the center of host immune responses. HLA genes are located in chromosome 6p21.31 and cover 0.13% of the human genome and show a high degree of polymorphism and extensive patterns of linkage disequilibrium (LD), which differ among populations. The HLA genes include HLA class I, HLA class II, and other non-HLA alleles. HLA class II gene polymorphisms are strongly associated with not only persistent HBV infection but also spontaneous HBV clearance and seroconversion, disease progression, and the development of liver cirrhosis (LC) and HBV-related hepatocellular carcinoma (HCC) in chronic hepatitis B. This chapter summarizes the reported associations of HLA class II gene polymorphisms with the outcomes of HBV infection and their related mechanisms.

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Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population

Cited by 18 publications

References 48 publications

Effect of HLA-DPA1 Alleles on Chronic Hepatitis B Prognosis and Treatment Response

Effect of HLA-DPA1 Alleles on Chronic Hepatitis B Prognosis and Treatment Response

Relationship between HLA‐DPA1 mRNA expression and susceptibility to hepatitis B

HLA Class II Allele Polymorphisms and the Clinical Outcomes of HBV Infection

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