Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: An experimental approach

Chauhan, Prerna; Sharma, Hemlata; Kumar, Uma; Mayachari, Anand; Sangli, Gopalkrishna; Singh, Sanjay

doi:10.1016/j.jep.2020.113209

Cited by 27 publications

(20 citation statements)

References 37 publications

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“…Its rhizomes and roots are used to treat renal, hepatic, gastric, and respiratory disorders. Recent findings established its role in numerous biological activities in the human body such as having an anti-inflammatory and antioxidant role and having a protective effect on various organs [ 21 ]. It is evident that licorice has a various health-promoting activities proved using preclinical and clinical trials; however, a comprehensive compilation of these research advances is lacking.…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health‐Promoting Abilities

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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The Glycyrrhiza genus, generally well-known as licorice, is broadly used for food and medicinal purposes around the globe. The genus encompasses a rich pool of bioactive molecules including triterpene saponins (e.g., glycyrrhizin) and flavonoids (e.g., liquiritigenin, liquiritin). This genus is being increasingly exploited for its biological effects such as antioxidant, antibacterial, antifungal, anti-inflammatory, antiproliferative, and cytotoxic activities. The species Glycyrrhiza glabra L. and the compound glycyrrhizin (glycyrrhizic acid) have been studied immensely for their effect on humans. The efficacy of the compound has been reported to be significantly higher on viral hepatitis and immune deficiency syndrome. This review provides up-to-date data on the most widely investigated Glycyrrhiza species for food and medicinal purposes, with special emphasis on secondary metabolites’ composition and bioactive effects.

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Section: Introductionmentioning

confidence: 99%

Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health‐Promoting Abilities

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…NF-κB encompasses an inducible transcription factor family that chiefly regulates host inflammatory and immune responses [ 107 ]. Several NF-κB activation reports have been recorded in the kidney after exposure to many drugs [ 108 , 109 ]. Herein, an apparent increase in NF-κB immuno-expression in the kidney tissue following SS administration was detected but suppressed following CUR treatment.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Curcumin against Sodium Salicylate-Induced Oxidative Kidney Damage, Nuclear Factor-Kappa Dysregulation, and Apoptotic Consequences in Rats

et al. 2021

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This study examined the effect of sodium salicylates (SS), alone and in combination with curcumin (CUR), on kidney function and architecture in rats. Five rat groups were given 1 mL physiological saline/rat orally, 1 mL olive oil/rat orally, 50 mg CUR/kg bwt orally, 300 mg SS/kg bwt intraperitoneally, or CUR+SS for 15 days. The hematological indices, serum protein profile, serum electrolytes balance, oxidative stress, and lipid peroxidation of kidney tissues were assessed. The histopathological examination and immune expression of Caspase-3 and nuclear factor kappa (NF-κB) were conducted. The findings showed that SS injection induced nephrotoxic activity, including increased serum urea, creatinine, and uric acid levels. It also caused apparent pathological alterations with increased Caspase-3 and NF-κB immuno-expression. In addition, thrombocytopenia, leukocytosis, neutrophilia, hyponatremia, hypochloremia, hypocalcemia, and hypomagnesemia but not hyperkalemia and hyperphosphatemia were evident in SS-injected rats. Moreover, SS exposure increased serum α1 globulin, renal tissue malondialdehyde, and Caspase-3 levels but superoxide dismutase, glutathione peroxidase, and Bcl-2 levels declined. Meanwhile, CUR significantly counteracted the SS harmful impacts on kidneys but SS+CUR co-administration induced an anemic condition. Overall, CUR has an evident protective role against SS-induced renal damage, but the disturbed hematological alterations should be carefully taken into consideration in their combined use.

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“…It has been demonstrated that ARE is restricted by intracellular ROS which are derived from MTX-PGs; these are additionally responsible for the downregulation of oxidant resistant mediators, e.g. Nrf2, HO-1 and NQO1 [32][33][34][35]. These studies also highlight MTX's oxidative stress-inducing potential in the tissue of the liver.…”

Section: Mini-review Articlementioning

confidence: 95%

Methotrexate Toxicity: Molecular Mechanisms and Management

Almalki

Kawy

Kamal

et al. 2021

JPRI

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Methotrexate (MTX) is the most widely used drug in cancer chemotherapy and is considered to be the first-line drug for the treatment of a number of rheumatic and non-rheumatic disorders. The pulmonary toxicity, hepatotoxicity of MTX are two of its major side effects. Other toxicities such as endocrinological toxicity, GI toxicity, cutaneous toxicity, hematological toxicity, fatal malfunction or loss, and malignancy can also occur, but at a significantly lower rate of prevalence. This review aims to provide a comprehensive understanding of the molecular mechanisms of methotrexate toxic effects and Lastly, we discussed the management of this toxicity.

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Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: An experimental approach

Cited by 27 publications

References 37 publications

Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health‐Promoting Abilities

Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health‐Promoting Abilities

Protective Effect of Curcumin against Sodium Salicylate-Induced Oxidative Kidney Damage, Nuclear Factor-Kappa Dysregulation, and Apoptotic Consequences in Rats

Methotrexate Toxicity: Molecular Mechanisms and Management

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